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TBK1 TANK binding kinase 1 [ Homo sapiens (human) ]

Gene ID: 29110, updated on 13-Apr-2024

Summary

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Official Symbol
TBK1provided by HGNC
Official Full Name
TANK binding kinase 1provided by HGNC
Primary source
HGNC:HGNC:11584
See related
Ensembl:ENSG00000183735 MIM:604834; AllianceGenome:HGNC:11584
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAK; T2K; IIAE8; FTDALS4
Summary
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response. [provided by RefSeq, Sep 2021]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in testis (RPKM 15.8), bone marrow (RPKM 10.3) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
12q14.2
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (64452120..64502114)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (64430747..64480735)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (64845900..64895894)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6592 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4619 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4620 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:64798894-64799770 Neighboring gene ribosomal protein S11 pseudogene 6 Neighboring gene exportin for tRNA Neighboring gene MPRA-validated peak1761 silencer Neighboring gene mitochondrial ribosomal protein S25 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6593 Neighboring gene uncharacterized LOC105369803 Neighboring gene Ras association domain family member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6594 Neighboring gene small nucleolar RNA SNORD83

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TBK1 promotes thyroid cancer progress by activating the PI3K/Akt/mTOR signaling pathway. Jiang Q, et al. Immun Inflamm Dis, 2023 Mar. PMID 36988258, Free PMC Article
  2. Serine/threonine kinase TBK1 promotes cholangiocarcinoma progression via direct regulation of β-catenin. Gao CQ, et al. Oncogene, 2023 May. PMID 36928362, Free PMC Article
  3. Functional Characterization of a Familial ALS-Associated Missense TBK1 (p-Arg573Gly) Mutation in Patient-Derived Lymphoblasts. Porras G, et al. Int J Mol Sci, 2023 Feb 2. PMID 36769169, Free PMC Article
  4. Correlation of TBK1, AR, and other serum cancer-related biomarkers in breast cancer patients: An observational study. Liu H, et al. Medicine (Baltimore), 2022 Aug 19. PMID 35984205, Free PMC Article
  5. TBK1 is part of a galectin 8 dependent membrane damage recognition complex and drives autophagy upon Adenovirus endosomal escape. Pied N, et al. PLoS Pathog, 2022 Jul. PMID 35857795, Free PMC Article

See all (469) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.
    Title: A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.
  2. AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer.
    Title: AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer.
  3. Optineurin provides a mitophagy contact site for TBK1 activation.
    Title: Optineurin provides a mitophagy contact site for TBK1 activation.
  4. Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma.
    Title: Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma.
  5. STING upregulation mediates ferroptosis and inflammatory response in lupus nephritis by upregulating TBK1 and activating NF-kappaB signal pathway.
    Title: STING upregulation mediates ferroptosis and inflammatory response in lupus nephritis by upregulating TBK1 and activating NF-κB signal pathway.
  6. Activating STING/TBK1 suppresses tumor growth via degrading HPV16/18 E7 oncoproteins in cervical cancer.
    Title: Activating STING/TBK1 suppresses tumor growth via degrading HPV16/18 E7 oncoproteins in cervical cancer.
  7. Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1.
    Title: Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1.
  8. NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis.
    Title: NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis.
  9. ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1.
    Title: ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1.
  10. CDK12 loss inhibits cell proliferation by regulating TBK1 in non-small cell lung cancer cells.
    Title: CDK12 loss inhibits cell proliferation by regulating TBK1 in non-small cell lung cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (247)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif co-immunoprecipitates with TBK1 suggesting an interaction between Vif and TBK1 PubMed
Vpr vpr HIV-1 Vpr co-immunoprecipitates with TBK1 suggesting an interaction between Vpr and TBK1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11330

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in antiviral innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cGAS/STING signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in canonical NF-kappaB signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in cytoplasmic pattern recognition receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to virus NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in dendritic cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response TAS
Traceable Author Statement
more info
 PubMed 
involved_in innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in innate immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of TORC1 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of interferon-alpha production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of macroautophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of type I interferon-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of xenophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of type I interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to virus TAS
Traceable Author Statement
more info
 PubMed 
involved_in toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
part_of serine/threonine protein kinase complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase TBK1
Names
NF-kB-activating kinase
NF-kappa-B-activating kinase
NP_037386.1
XP_005268866.1
XP_005268867.1
XP_054227832.1
XP_054227833.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046906.1 RefSeqGene

    Range
    5061..55055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1306

mRNA and Protein(s)

  1. NM_013254.4 → NP_037386.1  serine/threonine-protein kinase TBK1

    See identical proteins and their annotated locations for NP_037386.1

    Status: REVIEWED

    Source sequence(s)
    AA970899, AC135279, AC136977, BC034950
    Consensus CDS
    CCDS8968.1
    UniProtKB/Swiss-Prot
    A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2
    UniProtKB/TrEMBL
    A0A7I2V646
    Related
    ENSP00000329967.5, ENST00000331710.10
    Conserved Domains (3) summary
    smart00220
    Location:9 → 242
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd12219
    Location:297 → 385
    UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
    cd13988
    Location:15 → 330
    STKc_TBK1; Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    64452120..64502114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268810.2 → XP_005268867.1  serine/threonine-protein kinase TBK1 isoform X1

    See identical proteins and their annotated locations for XP_005268867.1

    UniProtKB/Swiss-Prot
    A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2
    UniProtKB/TrEMBL
    A0A7I2V646
    Conserved Domains (3) summary
    smart00220
    Location:9 → 242
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd12219
    Location:297 → 385
    UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
    cd13988
    Location:15 → 330
    STKc_TBK1; Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1

  2. XM_005268809.2 → XP_005268866.1  serine/threonine-protein kinase TBK1 isoform X1

    See identical proteins and their annotated locations for XP_005268866.1

    UniProtKB/Swiss-Prot
    A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2
    UniProtKB/TrEMBL
    A0A7I2V646
    Conserved Domains (3) summary
    smart00220
    Location:9 → 242
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd12219
    Location:297 → 385
    UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
    cd13988
    Location:15 → 330
    STKc_TBK1; Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1

RNA

  1. XR_007063071.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    64430747..64480735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371858.1 → XP_054227833.1  serine/threonine-protein kinase TBK1 isoform X1

    UniProtKB/Swiss-Prot
    A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2

  2. XM_054371857.1 → XP_054227832.1  serine/threonine-protein kinase TBK1 isoform X1

    UniProtKB/Swiss-Prot
    A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2

RNA

  1. XR_008488571.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UHD2.1 GenPept UniProtKB/Swiss-Prot:Q9UHD2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
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