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GRB7 growth factor receptor bound protein 7 [ Homo sapiens (human) ]

Gene ID: 2886, updated on 5-Mar-2024

Summary

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Official Symbol
GRB7provided by HGNC
Official Full Name
growth factor receptor bound protein 7provided by HGNC
Primary source
HGNC:HGNC:4567
See related
Ensembl:ENSG00000141738 MIM:601522; AllianceGenome:HGNC:4567
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Expression
Broad expression in kidney (RPKM 6.4), esophagus (RPKM 5.5) and 16 other tissues See more
Orthologs
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Genomic context

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Location:
17q12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (39737938..39747285)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (40601500..40610848)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37894191..37903538)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene erb-b2 receptor tyrosine kinase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37882556-37883528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8463 Neighboring gene microRNA 4728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37896451-37897048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37897647-37898244 Neighboring gene migration and invasion enhancer 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8464 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12108 Neighboring gene IKAROS family zinc finger 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:37934634-37934867 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:37940879-37941109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12110 Neighboring gene MPRA-validated peak2840 silencer Neighboring gene MPRA-validated peak2841 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37991649-37992148 Neighboring gene keratin 8 pseudogene 34 Neighboring gene ribosomal protein L39 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Upregulated GRB7 promotes proliferation and tumorigenesis of Bladder Cancer via Phospho-AKT Pathway. Zheng Y, et al. Int J Biol Sci, 2020. PMID 33162827, Free PMC Article
  2. Growth factor receptor bound protein-7 regulates proliferation, cell cycle, and mitochondrial apoptosis of thyroid cancer cells via MAPK/ERK signaling. Tang H, et al. Mol Cell Biochem, 2020 Sep. PMID 32577949
  3. Characterization of the full-length human Grb7 protein and a phosphorylation representative mutant. Bradford AM, et al. J Mol Recognit, 2019 Nov. PMID 31353673
  4. Grb7, a Critical Mediator of EGFR/ErbB Signaling, in Cancer Development and as a Potential Therapeutic Target. Chu PY, et al. Cells, 2019 May 10. PMID 31083325, Free PMC Article
  5. Grb7 is over-expressed in cervical cancer and facilitate invasion and inhibit apoptosis in cervical cancer cells. Zhao HB, et al. Pathol Res Pract, 2017 Sep. PMID 28780081

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GRB7 plays a promoting role in the progression of gastric cancer.
    Title: GRB7 plays a promoting role in the progression of gastric cancer.
  2. Knockdown of growth factor receptor bound protein 7 suppresses angiogenesis by inhibiting the secretion of vascular endothelial growth factor A in ovarian cancer cells.
    Title: Knockdown of growth factor receptor bound protein 7 suppresses angiogenesis by inhibiting the secretion of vascular endothelial growth factor A in ovarian cancer cells.
  3. Upregulated GRB7 promotes proliferation and tumorigenesis of Bladder Cancer via Phospho-AKT Pathway.
    Title: Upregulated GRB7 promotes proliferation and tumorigenesis of Bladder Cancer via Phospho-AKT Pathway.
  4. Growth factor receptor bound protein-7 regulates proliferation, cell cycle, and mitochondrial apoptosis of thyroid cancer cells via MAPK/ERK signaling.
    Title: Growth factor receptor bound protein-7 regulates proliferation, cell cycle, and mitochondrial apoptosis of thyroid cancer cells via MAPK/ERK signaling.
  5. GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma.
    Title: GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma.
  6. In vitro phosphorylation of the Grb7SH2 domain indicates only one of the available tyrosine residues is phosphorylated, suggesting the same phosphorylation pattern could be relevant in the full length protein.
    Title: Characterization of the full-length human Grb7 protein and a phosphorylation representative mutant.
  7. this is a review about the molecular, functional, and clinical aspects of Grb7 in erythroblastic leukemia viral oncogene homolog family-mediated cancer family-mediated cancer development and malignancy with the aim to reveal alternative and effective therapeutic strategies.[review]
    Title: Grb7, a Critical Mediator of EGFR/ErbB Signaling, in Cancer Development and as a Potential Therapeutic Target.
  8. It was identified that silencing of miR193a3p through hypermethylation can promote HER2 positive breast cancer progress by targeting GRB7, ERK1/2 and FOXM1 signaling.
    Title: Epigenetically altered miR‑193a‑3p promotes HER2 positive breast cancer aggressiveness by targeting GRB7.
  9. MiR-193a-3p not only modulated GRB7 but also ERBB4.
    Title: Methylation-associated silencing of miR-193a-3p promotes ovarian cancer aggressiveness by targeting GRB7 and MAPK/ERK pathways.
  10. Our results indicated that Grb7 over-expression may facilitate invasion and inhibit apoptosis in cervical cancer
    Title: Grb7 is over-expressed in cervical cancer and facilitate invasion and inhibit apoptosis in cervical cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
NOT involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in negative regulation of insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in stress granule assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
growth factor receptor-bound protein 7
Names
B47
GRB7 adapter protein
epidermal growth factor receptor GRB-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029932.2 RefSeqGene

    Range
    5002..14349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001030002.3 → NP_001025173.1  growth factor receptor-bound protein 7 isoform a

    See identical proteins and their annotated locations for NP_001025173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC079199
    Consensus CDS
    CCDS11345.1
    UniProtKB/Swiss-Prot
    B2RAV1, B3KNL0, B3KWP9, B7WP75, J3KQM4, Q14451, Q53YD3, Q92568, Q96DF9, Q9Y220
    UniProtKB/TrEMBL
    A0A0S2Z4F6
    Related
    ENSP00000377761.3, ENST00000394211.7
    Conserved Domains (4) summary
    cd01787
    Location:100 → 184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10413
    Location:425 → 532
    SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
    cd01259
    Location:225 → 347
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:366 → 410
    BPS; BPS (Between PH and SH2)

  2. NM_001242442.2 → NP_001229371.2  growth factor receptor-bound protein 7 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (b).
    Source sequence(s)
    AC079199
    Consensus CDS
    CCDS56028.1
    Related
    ENSP00000403459.2, ENST00000445327.6
    Conserved Domains (4) summary
    cd10413
    Location:448 → 555
    SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
    cd01259
    Location:248 → 370
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16140
    Location:123 → 210
    RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7
    pfam08947
    Location:389 → 433
    BPS; BPS (Between PH and SH2)

  3. NM_001242443.2 → NP_001229372.1  growth factor receptor-bound protein 7 isoform a

    See identical proteins and their annotated locations for NP_001229372.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC079199
    Consensus CDS
    CCDS11345.1
    UniProtKB/Swiss-Prot
    B2RAV1, B3KNL0, B3KWP9, B7WP75, J3KQM4, Q14451, Q53YD3, Q92568, Q96DF9, Q9Y220
    UniProtKB/TrEMBL
    A0A0S2Z4F6
    Related
    ENSP00000377759.2, ENST00000394209.6
    Conserved Domains (4) summary
    cd01787
    Location:100 → 184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10413
    Location:425 → 532
    SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
    cd01259
    Location:225 → 347
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:366 → 410
    BPS; BPS (Between PH and SH2)

  4. NM_001330207.2 → NP_001317136.1  growth factor receptor-bound protein 7 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC079199, BC006535
    Consensus CDS
    CCDS82116.1
    UniProtKB/Swiss-Prot
    Q14451
    Related
    ENSP00000377754.1, ENST00000394204.1
    Conserved Domains (3) summary
    cd01787
    Location:100 → 184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd01259
    Location:225 → 347
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:366 → 410
    BPS; BPS (Between PH and SH2)

  5. NM_005310.5 → NP_005301.2  growth factor receptor-bound protein 7 isoform a

    See identical proteins and their annotated locations for NP_005301.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC079199
    Consensus CDS
    CCDS11345.1
    UniProtKB/Swiss-Prot
    B2RAV1, B3KNL0, B3KWP9, B7WP75, J3KQM4, Q14451, Q53YD3, Q92568, Q96DF9, Q9Y220
    UniProtKB/TrEMBL
    A0A0S2Z4F6
    Related
    ENSP00000310771.4, ENST00000309156.9
    Conserved Domains (4) summary
    cd01787
    Location:100 → 184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10413
    Location:425 → 532
    SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
    cd01259
    Location:225 → 347
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:366 → 410
    BPS; BPS (Between PH and SH2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    39737938..39747285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435857.1 → XP_047291813.1  growth factor receptor-bound protein 7 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    40601500..40610848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315868.1 → XP_054171843.1  growth factor receptor-bound protein 7 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14451.2 GenPept UniProtKB/Swiss-Prot:Q14451

Gene LinkOut

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