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Ctdnep1 CTD nuclear envelope phosphatase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287447, updated on 11-Apr-2024

Summary

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Official Symbol
Ctdnep1provided by RGD
Official Full Name
CTD nuclear envelope phosphatase 1provided by RGD
Primary source
RGD:1310172
See related
Ensembl:ENSRNOG00000017352 AllianceGenome:RGD:1310172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dullard
Summary
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in several processes, including positive regulation of triglyceride biosynthetic process; protein dephosphorylation; and protein localization to nucleus. Predicted to act upstream of or within gamete generation; mesoderm development; and positive regulation of canonical Wnt signaling pathway. Predicted to be located in endoplasmic reticulum membrane; lipid droplet; and nuclear membrane. Predicted to be part of Nem1-Spo7 phosphatase complex. Orthologous to human CTDNEP1 (CTD nuclear envelope phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 174.6), Spleen (RPKM 98.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q24
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55203047..55212469)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54704367..54713781)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56590822..56600235)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene claudin 7 Neighboring gene elongator acetyltransferase complex subunit 5 Neighboring gene GABA type A receptor-associated protein Neighboring gene PHD finger protein 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A conserved phosphatase cascade that regulates nuclear membrane biogenesis. Kim Y, et al. Proc Natl Acad Sci U S A, 2007 Apr 17. PMID 17420445, Free PMC Article
  2. Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. Han S, et al. J Biol Chem, 2012 Jan 27. PMID 22134922, Free PMC Article
  3. Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo. Tanaka SS, et al. PLoS One, 2013. PMID 23469192, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in gamete generation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gamete generation ISO
Inferred from Sequence Orthology
more info
  
involved_in mesoderm development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mesoderm development ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear envelope organization IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear envelope organization ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear envelope organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Nem1-Spo7 phosphatase complex IEA
Inferred from Electronic Annotation
more info
  
part_of Nem1-Spo7 phosphatase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Nem1-Spo7 phosphatase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CTD nuclear envelope phosphatase 1
Names
serine/threonine-protein phosphatase dullard
NP_001093964.1
XP_006246705.2
XP_006246706.2
XP_063124715.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100494.1 → NP_001093964.1  CTD nuclear envelope phosphatase 1

    See identical proteins and their annotated locations for NP_001093964.1

    Status: VALIDATED

    Source sequence(s)
    BC107474, BU671232
    UniProtKB/Swiss-Prot
    Q3B7T6, Q5M952
    UniProtKB/TrEMBL
    A0A8L2QCF2, A6HFZ4
    Related
    ENSRNOP00000023379.5, ENSRNOT00000023379.5
    Conserved Domains (1) summary
    TIGR02251
    Location:61 → 229
    HIF-SF_euk; Dullard-like phosphatase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55203047..55212469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268645.1 → XP_063124715.1  CTD nuclear envelope phosphatase 1 isoform X3

  2. XM_006246643.5 → XP_006246705.2  CTD nuclear envelope phosphatase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QCF2
    Conserved Domains (1) summary
    TIGR02251
    Location:93 → 265
    HIF-SF_euk; Dullard-like phosphatase domain

  3. XM_006246644.5 → XP_006246706.2  CTD nuclear envelope phosphatase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GLT1, A0A8L2QCF2
    Related
    ENSRNOP00000096868.1
    Conserved Domains (1) summary
    TIGR02251
    Location:93 → 261
    HIF-SF_euk; Dullard-like phosphatase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3B7T6.2 GenPept UniProtKB/Swiss-Prot:Q3B7T6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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