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GRK4 G protein-coupled receptor kinase 4 [ Homo sapiens (human) ]

Gene ID: 2868, updated on 11-Apr-2024

Summary

Official Symbol
GRK4provided by HGNC
Official Full Name
G protein-coupled receptor kinase 4provided by HGNC
Primary source
HGNC:HGNC:4543
See related
Ensembl:ENSG00000125388 MIM:137026; AllianceGenome:HGNC:4543
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IT11; GPRK4; GRK4a; GPRK2L
Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Expression
Biased expression in testis (RPKM 14.6) and brain (RPKM 0.7) See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See GRK4 in Genome Data Viewer
Location:
4p16.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (2963571..3040760)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (2962247..3039448)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (2965298..3042487)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2935265-2936132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15194 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:2937390-2938589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21204 Neighboring gene NOP14 antisense RNA 1 Neighboring gene major facilitator superfamily domain containing 10 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:2948362-2949561 Neighboring gene NOP14 nucleolar protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21205 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:2964791-2965324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2965325-2965858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15196 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:3011160-3012359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3022951-3023451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21213 Neighboring gene RNA, U6 small nuclear 204, pseudogene Neighboring gene HTT antisense RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21214 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15199

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables rhodopsin kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of opsin-mediated signaling pathway TAS
Traceable Author Statement
more info
 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in photoreceptor disc membrane TAS
Traceable Author Statement
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
G protein-coupled receptor kinase 4
Names
G protein-coupled receptor kinase 2-like
NP_001004056.1
NP_001004057.1
NP_001337102.1
NP_005298.2
NP_892027.2
XP_005248019.1
XP_011511749.1
XP_011511750.1
XP_011511751.1
XP_011511752.1
XP_011511753.1
XP_011511754.1
XP_011511755.1
XP_011511756.1
XP_011511757.1
XP_011511758.1
XP_011511759.1
XP_016863541.1
XP_016863542.1
XP_016863543.1
XP_016863544.1
XP_016863545.1
XP_047306080.1
XP_047306081.1
XP_047306082.1
XP_047306083.1
XP_047306084.1
XP_054205768.1
XP_054205769.1
XP_054205770.1
XP_054205771.1
XP_054205772.1
XP_054205773.1
XP_054205774.1
XP_054205775.1
XP_054205776.1
XP_054205777.1
XP_054205778.1
XP_054205779.1
XP_054205780.1
XP_054205781.1
XP_054205782.1
XP_054205783.1
XP_054205784.1
XP_054205785.1
XP_054205786.1
XP_054205787.1
XP_054205788.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029102.1 RefSeqGene

    Range
    4956..82145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001004056.2NP_001004056.1  G protein-coupled receptor kinase 4 isoform beta

    See identical proteins and their annotated locations for NP_001004056.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (beta) has the same N- and C-termini but is shorter compared to isoform alpha.
    Source sequence(s)
    AL390065, BC027597, BI465220, BM725978, U33054
    Consensus CDS
    CCDS47002.1
    UniProtKB/TrEMBL
    A8K8M5
    Related
    ENSP00000264764.8, ENST00000345167.10
    Conserved Domains (3) summary
    cd05631
    Location:154438
    STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
    smart00220
    Location:155417
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:20152
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  2. NM_001004057.2NP_001004057.1  G protein-coupled receptor kinase 4 isoform gamma

    See identical proteins and their annotated locations for NP_001004057.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (gamma) has the same N- and C-termini but is shorter compared to isoform alpha.
    Source sequence(s)
    AL390065, BC027597, BI465220, BM725978
    Consensus CDS
    CCDS33947.1
    UniProtKB/TrEMBL
    A8K8M5
    Related
    ENSP00000427445.1, ENST00000504933.1
    Conserved Domains (3) summary
    cd05631
    Location:186470
    STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
    smart00220
    Location:187449
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  3. NM_001350173.2NP_001337102.1  G protein-coupled receptor kinase 4 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 5, which has a shorter and distinct N-terminus, compared to isoform alpha.
    Source sequence(s)
    AK223581, AK292390, AL390065, BI792406, N23898, X97881
    Conserved Domains (1) summary
    cl21453
    Location:5276
    PKc_like; Protein Kinases, catalytic domain
  4. NM_005307.3NP_005298.2  G protein-coupled receptor kinase 4 isoform delta

    See identical proteins and their annotated locations for NP_005298.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (delta) has the same N- and C-termini but is shorter compared to isoform alpha.
    Source sequence(s)
    AK223581, AL390065, X97879
    Consensus CDS
    CCDS68656.1
    UniProtKB/TrEMBL
    A8K8M5
    Related
    ENSP00000381128.4, ENST00000398051.8
    Conserved Domains (3) summary
    cd05631
    Location:154438
    STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
    smart00220
    Location:155417
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:20152
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  5. NM_182982.3NP_892027.2  G protein-coupled receptor kinase 4 isoform alpha

    See identical proteins and their annotated locations for NP_892027.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (alpha).
    Source sequence(s)
    AL390065, BC027597, BI465220, BM725978, U33054
    Consensus CDS
    CCDS33946.1
    UniProtKB/Swiss-Prot
    O00641, O00642, P32298, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316, Q17RH6, Q53EQ8
    UniProtKB/TrEMBL
    A8K8M5
    Related
    ENSP00000381129.4, ENST00000398052.9
    Conserved Domains (3) summary
    cd05631
    Location:186470
    STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
    smart00220
    Location:187449
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    2963571..3040760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513447.3XP_011511749.1  G protein-coupled receptor kinase 4 isoform X1

    UniProtKB/TrEMBL
    A8K8M5
    Conserved Domains (3) summary
    cd05631
    Location:186509
    STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
    smart00220
    Location:187488
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  2. XM_011513450.3XP_011511752.1  G protein-coupled receptor kinase 4 isoform X6

    UniProtKB/TrEMBL
    A8K8M5
    Conserved Domains (3) summary
    cd05631
    Location:186509
    STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
    smart00220
    Location:187488
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  3. XM_011513453.3XP_011511755.1  G protein-coupled receptor kinase 4 isoform X10

    UniProtKB/TrEMBL
    A8K8M5
    Conserved Domains (3) summary
    smart00220
    Location:187488
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:186508
    PKc_like; Protein Kinases, catalytic domain
  4. XM_011513451.3XP_011511753.1  G protein-coupled receptor kinase 4 isoform X7

    UniProtKB/TrEMBL
    A8K8M5
    Conserved Domains (3) summary
    smart00220
    Location:187462
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:186470
    PKc_like; Protein Kinases, catalytic domain
  5. XM_011513454.3XP_011511756.1  G protein-coupled receptor kinase 4 isoform X9

    UniProtKB/TrEMBL
    A8K8M5
    Conserved Domains (2) summary
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:186470
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011513455.3XP_011511757.1  G protein-coupled receptor kinase 4 isoform X12

    Conserved Domains (3) summary
    smart00220
    Location:187471
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:186472
    PKc_like; Protein Kinases, catalytic domain
  7. XM_017008053.2XP_016863542.1  G protein-coupled receptor kinase 4 isoform X4

    UniProtKB/TrEMBL
    A8K8M5
  8. XM_011513456.3XP_011511758.1  G protein-coupled receptor kinase 4 isoform X15

    Conserved Domains (2) summary
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:186363
    PKc_like; Protein Kinases, catalytic domain
  9. XM_017008054.2XP_016863543.1  G protein-coupled receptor kinase 4 isoform X11

    UniProtKB/TrEMBL
    A8K8M5
  10. XM_017008056.2XP_016863545.1  G protein-coupled receptor kinase 4 isoform X14

  11. XM_017008052.2XP_016863541.1  G protein-coupled receptor kinase 4 isoform X3

    UniProtKB/TrEMBL
    A8K8M5
  12. XM_011513449.3XP_011511751.1  G protein-coupled receptor kinase 4 isoform X5

    UniProtKB/TrEMBL
    A8K8M5
    Conserved Domains (3) summary
    cd05631
    Location:154477
    STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
    smart00220
    Location:155456
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:20152
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  13. XM_017008055.2XP_016863544.1  G protein-coupled receptor kinase 4 isoform X13

  14. XM_005247962.4XP_005248019.1  G protein-coupled receptor kinase 4 isoform X17

    See identical proteins and their annotated locations for XP_005248019.1

    Conserved Domains (2) summary
    smart00220
    Location:20238
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1259
    PKc_like; Protein Kinases, catalytic domain
  15. XM_011513452.3XP_011511754.1  G protein-coupled receptor kinase 4 isoform X8

    UniProtKB/TrEMBL
    A8K8M5
    Conserved Domains (2) summary
    cd08750
    Location:52184
    RGS_GRK4; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 4 (GRK4)
    cl21453
    Location:186470
    PKc_like; Protein Kinases, catalytic domain
  16. XM_011513448.3XP_011511750.1  G protein-coupled receptor kinase 4 isoform X2

    UniProtKB/TrEMBL
    A8K8M5
    Conserved Domains (2) summary
    cd05631
    Location:186509
    STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
    cd08750
    Location:52184
    RGS_GRK4; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 4 (GRK4)
  17. XM_047450128.1XP_047306084.1  G protein-coupled receptor kinase 4 isoform X19

  18. XM_047450127.1XP_047306083.1  G protein-coupled receptor kinase 4 isoform X19

  19. XM_011513457.3XP_011511759.1  G protein-coupled receptor kinase 4 isoform X18

    Conserved Domains (2) summary
    cl02565
    Location:52184
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:186286
    PKc_like; Protein Kinases, catalytic domain
  20. XM_047450125.1XP_047306081.1  G protein-coupled receptor kinase 4 isoform X17

  21. XM_047450126.1XP_047306082.1  G protein-coupled receptor kinase 4 isoform X17

  22. XM_047450124.1XP_047306080.1  G protein-coupled receptor kinase 4 isoform X16

RNA

  1. XR_924941.3 RNA Sequence

  2. XR_001741210.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    2962247..3039448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349793.1XP_054205768.1  G protein-coupled receptor kinase 4 isoform X1

  2. XM_054349798.1XP_054205773.1  G protein-coupled receptor kinase 4 isoform X6

  3. XM_054349802.1XP_054205777.1  G protein-coupled receptor kinase 4 isoform X10

  4. XM_054349799.1XP_054205774.1  G protein-coupled receptor kinase 4 isoform X7

  5. XM_054349801.1XP_054205776.1  G protein-coupled receptor kinase 4 isoform X9

  6. XM_054349804.1XP_054205779.1  G protein-coupled receptor kinase 4 isoform X12

  7. XM_054349796.1XP_054205771.1  G protein-coupled receptor kinase 4 isoform X4

  8. XM_054349807.1XP_054205782.1  G protein-coupled receptor kinase 4 isoform X15

  9. XM_054349803.1XP_054205778.1  G protein-coupled receptor kinase 4 isoform X11

  10. XM_054349806.1XP_054205781.1  G protein-coupled receptor kinase 4 isoform X14

  11. XM_054349795.1XP_054205770.1  G protein-coupled receptor kinase 4 isoform X3

  12. XM_054349797.1XP_054205772.1  G protein-coupled receptor kinase 4 isoform X5

  13. XM_054349805.1XP_054205780.1  G protein-coupled receptor kinase 4 isoform X13

  14. XM_054349810.1XP_054205785.1  G protein-coupled receptor kinase 4 isoform X17

  15. XM_054349800.1XP_054205775.1  G protein-coupled receptor kinase 4 isoform X8

  16. XM_054349794.1XP_054205769.1  G protein-coupled receptor kinase 4 isoform X2

  17. XM_054349813.1XP_054205788.1  G protein-coupled receptor kinase 4 isoform X19

  18. XM_054349812.1XP_054205787.1  G protein-coupled receptor kinase 4 isoform X18

  19. XM_054349809.1XP_054205784.1  G protein-coupled receptor kinase 4 isoform X17

  20. XM_054349811.1XP_054205786.1  G protein-coupled receptor kinase 4 isoform X17

  21. XM_054349808.1XP_054205783.1  G protein-coupled receptor kinase 4 isoform X16

RNA

  1. XR_008486968.1 RNA Sequence

  2. XR_008486969.1 RNA Sequence