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H2BW2 H2B.W histone 2 [ Homo sapiens (human) ]

Gene ID: 286436, updated on 5-Mar-2024

Summary

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Official Symbol
H2BW2provided by HGNC
Official Full Name
H2B.W histone 2provided by HGNC
Primary source
HGNC:HGNC:27867
See related
Ensembl:ENSG00000101812 AllianceGenome:HGNC:27867
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2BM; H2B/s; H2BFM
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the H2B histone family. [provided by RefSeq, Nov 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See H2BW2 in Genome Data Viewer
Location:
Xq22.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (104039956..104042454)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (102437461..102439959, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (103294523..103297021)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:103238205-103238704 Neighboring gene uncharacterized LOC107987334 Neighboring gene H2B.W histone 1 Neighboring gene uncharacterized LOC107985662 Neighboring gene H2B.W histone 3, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Studying the Evolution of Histone Variants Using Phylogeny. Molaro A, et al. Methods Mol Biol, 2018. PMID 30073533
  2. MS_HistoneDB, a manually curated resource for proteomic analysis of human and mouse histones. El Kennani S, et al. Epigenetics Chromatin, 2017. PMID 28096900, Free PMC Article
  3. A unified phylogeny-based nomenclature for histone variants. Talbert PB, et al. Epigenetics Chromatin, 2012 Jun 21. PMID 22650316, Free PMC Article
  4. Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry. Niture SK, et al. Biochem Biophys Res Commun, 2005 Dec 2. PMID 16226712
  5. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histone H2B type F-M
Names
H2B histone family member M
H2B.M histone
histone H2B.s

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164416.4 → NP_001157888.2  histone H2B type F-M

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC234782
    Consensus CDS
    CCDS55468.2
    Related
    ENSP00000347119.4, ENST00000355016.8
    Conserved Domains (1) summary
    cl23830
    Location:52 → 139
    H2B; Histone H2B

  2. NM_001388464.1 → NP_001375393.1  histone H2B type F-M

    Status: REVIEWED

    Source sequence(s)
    AC234782
    Consensus CDS
    CCDS55468.2
    Related
    ENSP00000502072.2, ENST00000675318.3
    Conserved Domains (1) summary
    cl23830
    Location:52 → 139
    H2B; Histone H2B

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    104039956..104042454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530922.3 → XP_011529224.1  histone H2B type F-M isoform X1

    See identical proteins and their annotated locations for XP_011529224.1

    UniProtKB/Swiss-Prot
    A6NP82, P0C1H6
    UniProtKB/TrEMBL
    W0TYI6
    Conserved Domains (1) summary
    cl23830
    Location:58 → 145
    H2B; Histone H2B

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    102437461..102439959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326899.1 → XP_054182874.1  histone H2B type F-M isoform X2

    UniProtKB/Swiss-Prot
    A6NP82, P0C1H6
    UniProtKB/TrEMBL
    W0TYI6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001377073.1: Suppressed sequence

    Description
    NM_001377073.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C1H6.2 GenPept UniProtKB/Swiss-Prot:P0C1H6

Gene LinkOut

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