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DPY19L4 dpy-19 like 4 [ Homo sapiens (human) ]

Gene ID: 286148, updated on 5-Mar-2024

Summary

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Official Symbol
DPY19L4provided by HGNC
Official Full Name
dpy-19 like 4provided by HGNC
Primary source
HGNC:HGNC:27829
See related
Ensembl:ENSG00000156162 MIM:613895; AllianceGenome:HGNC:27829
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable mannosyltransferase activity. Predicted to be involved in protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan. Predicted to be integral component of membrane. Predicted to be active in nuclear inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 10.0), ovary (RPKM 7.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
8q22.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (94719900..94793836)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (95844880..95918818)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (95732128..95806064)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27633 Neighboring gene long intergenic non-protein coding RNA 2894 Neighboring gene epithelial splicing regulatory protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27634 Neighboring gene ribosomal protein S15a pseudogene 26 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:95731221-95732175 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27635 Neighboring gene integrator complex subunit 8 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene cyclin E2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. Tsuritani K, et al. Genome Res, 2007 Jul. PMID 17567985, Free PMC Article
  2. The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901, Free PMC Article
  3. From ORFeome to biology: a functional genomics pipeline. Wiemann S, et al. Genome Res, 2004 Oct. PMID 15489336, Free PMC Article
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Wiemann S, et al. Genome Res, 2001 Mar. PMID 11230166, Free PMC Article
  5. DNA cloning using in vitro site-specific recombination. Hartley JL, et al. Genome Res, 2000 Nov. PMID 11076863, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC131885

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable C-mannosyltransferase DPY19L4
Names
dpy-19-like protein 4
protein dpy-19 homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181787.3 → NP_861452.2  probable C-mannosyltransferase DPY19L4

    See identical proteins and their annotated locations for NP_861452.2

    Status: VALIDATED

    Source sequence(s)
    AP003692, BC110870, BP873374
    Consensus CDS
    CCDS34924.1
    UniProtKB/Swiss-Prot
    Q6ZW32, Q6ZW42, Q7Z329, Q7Z388
    Related
    ENSP00000389630.2, ENST00000414645.6
    Conserved Domains (1) summary
    pfam10034
    Location:62 → 714
    Dpy19; Q-cell neuroblast polarization

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    94719900..94793836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250894.5 → XP_005250951.2  probable C-mannosyltransferase DPY19L4 isoform X1

  2. XM_047421714.1 → XP_047277670.1  probable C-mannosyltransferase DPY19L4 isoform X2

  3. XM_011516983.4 → XP_011515285.1  probable C-mannosyltransferase DPY19L4 isoform X3

    Conserved Domains (1) summary
    pfam10034
    Location:62 → 681
    Dpy19; Q-cell neuroblast polarization

  4. XM_017013351.3 → XP_016868840.1  probable C-mannosyltransferase DPY19L4 isoform X5

  5. XM_011516984.4 → XP_011515286.1  probable C-mannosyltransferase DPY19L4 isoform X4

    Conserved Domains (1) summary
    pfam10034
    Location:62 → 672
    Dpy19; Q-cell neuroblast polarization

  6. XM_017013352.3 → XP_016868841.1  probable C-mannosyltransferase DPY19L4 isoform X6

  7. XM_047421715.1 → XP_047277671.1  probable C-mannosyltransferase DPY19L4 isoform X7

  8. XM_047421716.1 → XP_047277672.1  probable C-mannosyltransferase DPY19L4 isoform X8

  9. XM_047421717.1 → XP_047277673.1  probable C-mannosyltransferase DPY19L4 isoform X9

  10. XM_047421718.1 → XP_047277674.1  probable C-mannosyltransferase DPY19L4 isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    95844880..95918818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360333.1 → XP_054216308.1  probable C-mannosyltransferase DPY19L4 isoform X1

  2. XM_054360334.1 → XP_054216309.1  probable C-mannosyltransferase DPY19L4 isoform X2

  3. XM_054360335.1 → XP_054216310.1  probable C-mannosyltransferase DPY19L4 isoform X3

  4. XM_054360337.1 → XP_054216312.1  probable C-mannosyltransferase DPY19L4 isoform X5

  5. XM_054360336.1 → XP_054216311.1  probable C-mannosyltransferase DPY19L4 isoform X4

  6. XM_054360338.1 → XP_054216313.1  probable C-mannosyltransferase DPY19L4 isoform X6

  7. XM_054360339.1 → XP_054216314.1  probable C-mannosyltransferase DPY19L4 isoform X7

  8. XM_054360340.1 → XP_054216315.1  probable C-mannosyltransferase DPY19L4 isoform X8

  9. XM_054360341.1 → XP_054216316.1  probable C-mannosyltransferase DPY19L4 isoform X9

  10. XM_054360342.1 → XP_054216317.1  probable C-mannosyltransferase DPY19L4 isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z388.1 GenPept UniProtKB/Swiss-Prot:Q7Z388

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