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RGMB repulsive guidance molecule BMP co-receptor b [ Homo sapiens (human) ]

Gene ID: 285704, updated on 5-Mar-2024

Summary

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Official Symbol
RGMBprovided by HGNC
Official Full Name
repulsive guidance molecule BMP co-receptor bprovided by HGNC
Primary source
HGNC:HGNC:26896
See related
Ensembl:ENSG00000174136 MIM:612687; AllianceGenome:HGNC:26896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRAGON
Summary
RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009]
Expression
Ubiquitous expression in brain (RPKM 10.1), skin (RPKM 10.1) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See RGMB in Genome Data Viewer
Location:
5q15
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (98768632..98796494)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (99271925..99299789)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (98104336..98132198)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CTBP2 pseudogene 4 Neighboring gene DEAD-box helicase 18 pseudogene 4 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:98102871-98103612 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:98103613-98104353 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:98106065-98106565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22835 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:98109729-98110228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22836 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:98114818-98116017 Neighboring gene RGMB antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:98175311-98175811 Neighboring gene uncharacterized LOC105379099 Neighboring gene casein kinase 1 alpha 1 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Repulsive guidance molecule B inhibits metastasis and is associated with decreased mortality in non-small cell lung cancer. Li J, et al. Oncotarget, 2016 Mar 29. PMID 26910889, Free PMC Article
  2. Repulsive guidance molecule B (RGMB) plays negative roles in breast cancer by coordinating BMP signaling. Li J, et al. J Cell Biochem, 2012 Jul. PMID 22415859
  3. Repulsive guidance molecule b inhibits neurite growth and is increased after spinal cord injury. Liu X, et al. Biochem Biophys Res Commun, 2009 May 15. PMID 19324014
  4. Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex. Malinauskas T, et al. Proc Natl Acad Sci U S A, 2020 Jul 7. PMID 32576689, Free PMC Article
  5. RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-4. Sekiya T, et al. Sci Rep, 2019 May 6. PMID 31061392, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.
    Title: RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.
  2. RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-4.
    Title: RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-4.
  3. Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
    Title: Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
  4. Our results demonstrate that RGMB is an important inhibitor of non-small cell lung cancer metastasis and that low RGMB expression is a novel predictor or a poor prognosis.
    Title: Repulsive guidance molecule B inhibits metastasis and is associated with decreased mortality in non-small cell lung cancer.
  5. Data show that Dragon expression was increased in colon cancer tissues compared to control tissues in CAC mouse model and in human patients.
    Title: Dragon (repulsive guidance molecule b, RGMb) is a novel gene that promotes colorectal cancer growth.
  6. RGMB was down-regulation in non-small cell lung cancer.
    Title: Study on expression of lncRNA RGMB-AS1 and repulsive guidance molecule b in non-small cell lung cancer.
  7. Study highlights the potential importance of RGMb in propagating pro-angiogenic effects of HGF and BMP-7.
    Title: Tumour angiogenesis and repulsive guidance molecule b: a role in HGF- and BMP-7-mediated angiogenesis.
  8. two RGMB ectodomains conformationally stabilize the juxtamembrane regions of two NEO1 receptors in a pH-dependent manner.
    Title: Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub.
  9. current data firstly revealed that RGMB may act as a negative regulator in breast cancer through BMP signaling
    Title: Repulsive guidance molecule B (RGMB) plays negative roles in breast cancer by coordinating BMP signaling.
  10. The expression of RGMA, RGMB and RGMC was evident in most examined prostate cancer cell lines, and also in the prostate cancer tissues
    Title: Repulsive guidance molecules, novel bone morphogenetic protein co-receptors, are key regulators of the growth and aggressiveness of prostate cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.
EBI GWAS Catalog
Variants in several genomic regions associated with asperger disorder.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ90406, MGC86970, DKFZp434P228

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables coreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum-Golgi intermediate compartment ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
repulsive guidance molecule B
Names
DRG11-responsive axonal guidance and outgrowth of neurite
RGM domain family, member B
repulsive guidance molecule family member b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012761.3 → NP_001012779.2  repulsive guidance molecule B isoform 2

    See identical proteins and their annotated locations for NP_001012779.2

    Status: VALIDATED

    Source sequence(s)
    AC008522, AK054622, BC020513, BC067736
    Consensus CDS
    CCDS47251.1
    UniProtKB/TrEMBL
    J3KNF6
    Related
    ENSP00000308219.7, ENST00000308234.11
    Conserved Domains (2) summary
    pfam06534
    Location:267 → 441
    RGM_C; Repulsive guidance molecule (RGM) C-terminus
    pfam06535
    Location:95 → 262
    RGM_N; Repulsive guidance molecule (RGM) N-terminus

  2. NM_001366508.1 → NP_001353437.1  repulsive guidance molecule B isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC008522
    Consensus CDS
    CCDS93751.1
    UniProtKB/Swiss-Prot
    D6R9A0, Q6NW40, Q8NC92
    Related
    ENSP00000423256.1, ENST00000513185.3
    Conserved Domains (2) summary
    pfam06534
    Location:226 → 400
    RGM_C; Repulsive guidance molecule (RGM) C-terminus
    pfam06535
    Location:54 → 221
    RGM_N; Repulsive guidance molecule (RGM) N-terminus

  3. NM_001366509.1 → NP_001353438.1  repulsive guidance molecule B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008522
    Consensus CDS
    CCDS47251.1
    UniProtKB/TrEMBL
    J3KNF6
    Conserved Domains (2) summary
    pfam06534
    Location:267 → 441
    RGM_C; Repulsive guidance molecule (RGM) C-terminus
    pfam06535
    Location:95 → 262
    RGM_N; Repulsive guidance molecule (RGM) N-terminus

  4. NM_001366510.1 → NP_001353439.1  repulsive guidance molecule B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008522
    Consensus CDS
    CCDS47251.1
    UniProtKB/TrEMBL
    J3KNF6
    Conserved Domains (2) summary
    pfam06534
    Location:267 → 441
    RGM_C; Repulsive guidance molecule (RGM) C-terminus
    pfam06535
    Location:95 → 262
    RGM_N; Repulsive guidance molecule (RGM) N-terminus

  5. NM_001366511.1 → NP_001353440.1  repulsive guidance molecule B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008522
    Conserved Domains (2) summary
    pfam06534
    Location:266 → 440
    RGM_C; Repulsive guidance molecule (RGM) C-terminus
    pfam06535
    Location:94 → 261
    RGM_N; Repulsive guidance molecule (RGM) N-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    98768632..98796494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417124.1 → XP_047273080.1  repulsive guidance molecule B isoform X1

  2. XM_047417125.1 → XP_047273081.1  repulsive guidance molecule B isoform X3

    UniProtKB/Swiss-Prot
    D6R9A0, Q6NW40, Q8NC92

  3. XM_011543345.3 → XP_011541647.1  repulsive guidance molecule B isoform X2

    See identical proteins and their annotated locations for XP_011541647.1

    UniProtKB/TrEMBL
    J3KNF6
    Conserved Domains (2) summary
    pfam06534
    Location:267 → 441
    RGM_C; Repulsive guidance molecule (RGM) C-terminus
    pfam06535
    Location:95 → 262
    RGM_N; Repulsive guidance molecule (RGM) N-terminus

  4. XM_011543346.3 → XP_011541648.1  repulsive guidance molecule B isoform X4

    Conserved Domains (2) summary
    pfam06534
    Location:185 → 364
    RGM_C; Repulsive guidance molecule (RGM) C-terminus
    pfam06535
    Location:13 → 180
    RGM_N; Repulsive guidance molecule (RGM) N-terminus

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    99271925..99299789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352457.1 → XP_054208432.1  repulsive guidance molecule B isoform X1

  2. XM_054352458.1 → XP_054208433.1  repulsive guidance molecule B isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173670.2: Suppressed sequence

    Description
    NM_173670.2: This RefSeq was permanently suppressed because there is insufficient support for the alternate terminal exon represented by this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NW40.3 GenPept UniProtKB/Swiss-Prot:Q6NW40

Gene LinkOut

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