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ZNF454 zinc finger protein 454 [ Homo sapiens (human) ]

Gene ID: 285676, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF454provided by HGNC
Official Full Name
zinc finger protein 454provided by HGNC
Primary source
HGNC:HGNC:21200
See related
Ensembl:ENSG00000178187 AllianceGenome:HGNC:21200
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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Location:
5q35.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (178941198..178990028)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (179494467..179543363)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (178368199..178393434)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ZFP2 zinc finger protein Neighboring gene phosphatidylinositol glycan anchor biosynthesis class F pseudogene 1 Neighboring gene ZNF454 divergent transcript Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83773 Neighboring gene glutamate metabotropic receptor 6 Neighboring gene F-box and WD repeat domain containing 2 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:178450433-178450934 Neighboring gene zinc finger protein 879

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Methylation‑driven genes PMPCAP1, SOWAHC and ZNF454 as potential prognostic biomarkers in lung squamous cell carcinoma. Zhu Q, et al. Mol Med Rep, 2020 Mar. PMID 32016477, Free PMC Article
  2. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
  3. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629, Free PMC Article
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Methylationdriven genes PMPCAP1, SOWAHC and ZNF454 as potential prognostic biomarkers in lung squamous cell carcinoma.
    Title: Methylation‑driven genes PMPCAP1, SOWAHC and ZNF454 as potential prognostic biomarkers in lung squamous cell carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37444, MGC138481

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 454

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001178089.3 → NP_001171560.1  zinc finger protein 454 isoform 1

    See identical proteins and their annotated locations for NP_001171560.1

    Status: VALIDATED

    Source sequence(s)
    AC104117, AK094763, AK292317, DA081954
    Consensus CDS
    CCDS4441.1
    UniProtKB/Swiss-Prot
    Q2M1P2, Q2M323, Q8N9F8
    Related
    ENSP00000430354.1, ENST00000519564.2
    Conserved Domains (6) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:186 → 522
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:330 → 350
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:178 → 200
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:482 → 507
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001178090.3 → NP_001171561.1  zinc finger protein 454 isoform 1

    See identical proteins and their annotated locations for NP_001171561.1

    Status: VALIDATED

    Source sequence(s)
    AC104117, AK094763, BC112276, DA081954, DA331325
    Consensus CDS
    CCDS4441.1
    UniProtKB/Swiss-Prot
    Q2M1P2, Q2M323, Q8N9F8
    Conserved Domains (6) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:186 → 522
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:330 → 350
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:178 → 200
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:482 → 507
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001323306.2 → NP_001310235.1  zinc finger protein 454 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC104117
    Consensus CDS
    CCDS4441.1
    UniProtKB/Swiss-Prot
    Q2M1P2, Q2M323, Q8N9F8
    Conserved Domains (6) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:186 → 522
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:330 → 350
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:178 → 200
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:482 → 507
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001323307.2 → NP_001310236.1  zinc finger protein 454 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104117

  5. NM_001323308.2 → NP_001310237.1  zinc finger protein 454 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104117

  6. NM_001323309.2 → NP_001310238.1  zinc finger protein 454 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104117

  7. NM_001323310.2 → NP_001310239.1  zinc finger protein 454 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104117

  8. NM_182594.4 → NP_872400.2  zinc finger protein 454 isoform 1

    See identical proteins and their annotated locations for NP_872400.2

    Status: VALIDATED

    Source sequence(s)
    AC104117, AK094763, BC112276, DA081954
    Consensus CDS
    CCDS4441.1
    UniProtKB/Swiss-Prot
    Q2M1P2, Q2M323, Q8N9F8
    Related
    ENSP00000326249.3, ENST00000320129.7
    Conserved Domains (6) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:186 → 522
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:330 → 350
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:178 → 200
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:482 → 507
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    178941198..178990028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007058600.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    179494467..179543363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008487112.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N9F8.2 GenPept UniProtKB/Swiss-Prot:Q8N9F8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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