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KIF4B kinesin family member 4B [ Homo sapiens (human) ]

Gene ID: 285643, updated on 5-Mar-2024

Summary

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Official Symbol
KIF4Bprovided by HGNC
Official Full Name
kinesin family member 4Bprovided by HGNC
Primary source
HGNC:HGNC:6322
See related
Ensembl:ENSG00000226650 MIM:609184; AllianceGenome:HGNC:6322
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is an intronless retrocopy of kinesin family member 4A. The protein encoded by this gene is a microtubule-based motor protein that plays vital roles in anaphase spindle dynamics and cytokinesis. [provided by RefSeq, Jul 2016]
Orthologs
all
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Genomic context

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Location:
5q33.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (155013755..155018141)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (155547646..155552032)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (154393315..154397701)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23491 Neighboring gene mitochondrial ribosomal protein L22 Neighboring gene cytochrome c oxidase subunit 7A2 like pseudogene Neighboring gene Sharpr-MPRA regulatory region 11709 Neighboring gene NANOG hESC enhancer GRCh37_chr5:154428817-154429318 Neighboring gene uncharacterized LOC105378239 Neighboring gene ribosomal protein L6 pseudogene 32

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization. Ha MJ, et al. Cytogenet Cell Genet, 2000. PMID 10773663
  2. Cellular motor protein KIF-4 associates with retroviral Gag. Tang Y, et al. J Virol, 1999 Dec. PMID 10559369, Free PMC Article
  3. Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein. Oh S, et al. Biochim Biophys Acta, 2000 Sep 7. PMID 10978527
  4. Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein. Martinez NW, et al. J Virol, 2008 Oct. PMID 18684836, Free PMC Article
  5. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Zhu C, et al. Mol Biol Cell, 2005 Jul. PMID 15843429, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Disrupting the function of KIF4 leads Gag transient accumulation in discrete, perinuclear, nonendocytic clusters that co-localize with endogenous KIF4, Ubc9, and SUMO PubMed
gag Binding of HIV-1 Gag to KIF-4 may play a role in HIV-1 Gag polyprotein transport from the cytoplasm to the cell membrane PubMed
gag Binding of human KIF-4 to HIV-1 Gag is presumed based on homology to murine KIF-4 which binds to an HIV-1 Gag intermediate, consisting of Matrix and Capsid, in a yeast two-hybrid assay and in co-immunoprecipitation assays PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle midzone assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
part_of microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
chromosome-associated kinesin KIF4B
Names
chromokinesin KIF4B
chromokinesin-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099293.3 → NP_001092763.1  chromosome-associated kinesin KIF4B

    See identical proteins and their annotated locations for NP_001092763.1

    Status: REVIEWED

    Source sequence(s)
    AC008410, AK302388
    Consensus CDS
    CCDS47324.1
    UniProtKB/Swiss-Prot
    Q2VIQ3
    UniProtKB/TrEMBL
    B4DYE2
    Related
    ENSP00000387875.3, ENST00000435029.6
    Conserved Domains (4) summary
    smart00129
    Location:9 → 343
    KISc; Kinesin motor, catalytic domain. ATPase
    COG0419
    Location:406 → 995
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01372
    Location:8 → 337
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam05033
    Location:1072 → 1122
    Pre-SET; Pre-SET motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    155013755..155018141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    155547646..155552032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2VIQ3.2 GenPept UniProtKB/Swiss-Prot:Q2VIQ3

Gene LinkOut

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