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EPHA6 EPH receptor A6 [ Homo sapiens (human) ]

Gene ID: 285220, updated on 10-Dec-2024

Summary

Official Symbol
EPHA6provided by HGNC
Official Full Name
EPH receptor A6provided by HGNC
Primary source
HGNC:HGNC:19296
See related
Ensembl:ENSG00000080224 MIM:600066; AllianceGenome:HGNC:19296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EHK2; EK12; EPA6; EHK-2; HEK12; PRO57066
Summary
Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance and ephrin receptor signaling pathway. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See EPHA6 in Genome Data Viewer
Location:
3q11.2
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (96814594..97761532)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (99518416..100468755)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (96533438..97480376)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:96513110-96513654 Neighboring gene uncharacterized LOC124909397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14551 Neighboring gene CDV3 pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:96606342-96607541 Neighboring gene uncharacterized LOC107986103 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:96844549-96845271 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:96995547-96996405 Neighboring gene uncharacterized LOC101929278 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:97108697-97109268 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:97107500-97108060 Neighboring gene TPTE2 pseudogene 7 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:97381594-97382192 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:97406521-97407050 Neighboring gene NANOG hESC enhancer GRCh37_chr3:97430329-97430833 Neighboring gene uncharacterized LOC124906256 Neighboring gene NANOG hESC enhancer GRCh37_chr3:97466009-97466510 Neighboring gene H3K27ac hESC enhancers GRCh37_chr3:97482933-97483434 and GRCh37_chr3:97483435-97483934 Neighboring gene uncharacterized LOC101929298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14552 Neighboring gene uncharacterized LOC105373994 Neighboring gene ARF like GTPase 6 Neighboring gene crystallin beta-gamma domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Interactions

General gene information

Clone Names

  • FLJ35246, DKFZp434C1418

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding  
enables GPI-linked ephrin receptor activity  
enables boss receptor activity  
enables brain-derived neurotrophic factor receptor activity  
enables epidermal growth factor receptor activity  
enables fibroblast growth factor receptor activity  
enables hepatocyte growth factor receptor activity  
enables histone H2AXY142 kinase activity  
enables histone H3Y41 kinase activity  
enables insulin receptor activity  
enables insulin-like growth factor receptor activity  
enables macrophage colony-stimulating factor receptor activity  
enables placental growth factor receptor activity  
enables platelet-derived growth factor alpha-receptor activity  
enables platelet-derived growth factor beta-receptor activity  
enables protein binding PubMed 
enables protein tyrosine kinase collagen receptor activity  
enables stem cell factor receptor activity  
enables transmembrane-ephrin receptor activity  
enables vascular endothelial growth factor receptor activity  
Process Evidence Code Pubs
involved_in Kit signaling pathway  
involved_in axon guidance  
involved_in brain-derived neurotrophic factor receptor signaling pathway  
involved_in chromatin remodeling  
involved_in collagen-activated tyrosine kinase receptor signaling pathway  
involved_in ephrin receptor signaling pathway  
involved_in epidermal growth factor receptor signaling pathway  
involved_in fibroblast growth factor receptor signaling pathway  
involved_in hepatocyte growth factor receptor signaling pathway  
involved_in insulin receptor signaling pathway  
involved_in insulin-like growth factor receptor signaling pathway  
involved_in macrophage colony-stimulating factor signaling pathway  
involved_in platelet-derived growth factor receptor-alpha signaling pathway  
involved_in platelet-derived growth factor receptor-beta signaling pathway  
involved_in vascular endothelial growth factor receptor-1 signaling pathway  
involved_in vascular endothelial growth factor signaling pathway  
Component Evidence Code Pubs
is_active_in dendrite  
located_in nucleoplasm  
is_active_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
ephrin type-A receptor 6
Names
EPH homology kinase 2
EPH-like kinase 12
ephrin receptor EphA6
NP_001073917.2
NP_001265229.1
NP_001265230.1
NP_775926.1
XP_006713655.1
XP_011511007.1
XP_011511008.1
XP_011511009.1
XP_016861699.1
XP_016861700.1
XP_016861701.1
XP_016861702.1
XP_016861703.1
XP_016861704.2
XP_016861705.2
XP_016861706.1
XP_016861707.1
XP_016861708.1
XP_047303964.1
XP_047303965.1
XP_054202245.1
XP_054202246.1
XP_054202247.1
XP_054202248.1
XP_054202249.1
XP_054202250.1
XP_054202251.1
XP_054202252.1
XP_054202253.1
XP_054202254.1
XP_054202255.1
XP_054202256.1
XP_054202257.1
XP_054202258.1
XP_054202259.1
XP_054202260.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080448.3NP_001073917.2  ephrin type-A receptor 6 isoform a

    See identical proteins and their annotated locations for NP_001073917.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC107482, AC110491, AC117439, AC117470, AC119745, AC130510, AC135369, BM676895, DA385338
    Consensus CDS
    CCDS46876.1
    UniProtKB/Swiss-Prot
    D6RAL5, Q9UF33
    UniProtKB/TrEMBL
    A0A0B4J1T8
    Related
    ENSP00000374323.5, ENST00000389672.10
    Conserved Domains (8) summary
    cd09547
    Location:10551118
    SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors
    smart00454
    Location:10521119
    SAM; Sterile alpha motif
    cd10484
    Location:128300
    EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6
    cd00063
    Location:537628
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:7201028
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:427521
    fn3; Fibronectin type III domain
    pfam07714
    Location:7251024
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:648720
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  2. NM_001278300.2NP_001265229.1  ephrin type-A receptor 6 isoform c

    See identical proteins and their annotated locations for NP_001265229.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple differences at the 5' and 3' ends, compared to variant 1. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (c) is shorter and has distinct N- and C- termini, compared to isoform a.
    Source sequence(s)
    AC117439, AC117470, AL133666, BC067287, DC398430
    Consensus CDS
    CCDS63697.1
    UniProtKB/Swiss-Prot
    Q9UF33
    Related
    ENSP00000421711.1, ENST00000514100.5
    Conserved Domains (3) summary
    pfam07714
    Location:117320
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:40112
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:112320
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001278301.2NP_001265230.1  ephrin type-A receptor 6 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks multiple 3' exons, and includes an alternate 3' exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC119745, AY358738, DA385338
    UniProtKB/TrEMBL
    H0Y9V0
    Related
    ENSP00000425132.1, ENST00000506569.1
    Conserved Domains (1) summary
    cd10484
    Location:128300
    EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6
  4. NM_173655.4NP_775926.1  ephrin type-A receptor 6 isoform b

    See identical proteins and their annotated locations for NP_775926.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains multiple differences at the 5' and 3' ends, compared to variant 1. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (b) is shorter and has distinct N- and C- termini, compared to isoform a.
    Source sequence(s)
    AL133666, DC398430
    Consensus CDS
    CCDS54616.1
    UniProtKB/Swiss-Prot
    Q9UF33
    Related
    ENSP00000423950.1, ENST00000502694.1
    Conserved Domains (3) summary
    pfam07714
    Location:117321
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:40112
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:112320
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    96814594..97761532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006211.2XP_016861700.1  ephrin type-A receptor 6 isoform X4

    UniProtKB/Swiss-Prot
    D6RAL5, Q9UF33
    Conserved Domains (8) summary
    cd09547
    Location:9431006
    SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors
    smart00454
    Location:9401007
    SAM; Sterile alpha motif
    cd00063
    Location:409516
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:608916
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:299393
    fn3; Fibronectin type III domain
    pfam07714
    Location:613912
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:536608
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:23172
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
  2. XM_006713592.4XP_006713655.1  ephrin type-A receptor 6 isoform X1

    UniProtKB/Swiss-Prot
    D6RAL5, Q9UF33
    Conserved Domains (8) summary
    cd09547
    Location:10711134
    SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors
    smart00454
    Location:10681135
    SAM; Sterile alpha motif
    cd10484
    Location:128300
    EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6
    cd00063
    Location:537644
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:7361044
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:427521
    fn3; Fibronectin type III domain
    pfam07714
    Location:7411040
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:664736
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  3. XM_017006210.2XP_016861699.1  ephrin type-A receptor 6 isoform X2

    UniProtKB/Swiss-Prot
    D6RAL5, Q9UF33
  4. XM_047448008.1XP_047303964.1  ephrin type-A receptor 6 isoform X3

    UniProtKB/Swiss-Prot
    D6RAL5, Q9UF33
  5. XM_017006214.2XP_016861703.1  ephrin type-A receptor 6 isoform X7

  6. XM_017006219.2XP_016861708.1  ephrin type-A receptor 6 isoform X11

    UniProtKB/TrEMBL
    E7EU71
    Related
    ENSP00000420598.2, ENST00000470610.6
  7. XM_011512705.3XP_011511007.1  ephrin type-A receptor 6 isoform X13

    Conserved Domains (1) summary
    cd10484
    Location:128300
    EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6
  8. XM_011512706.3XP_011511008.1  ephrin type-A receptor 6 isoform X14

    UniProtKB/TrEMBL
    H0Y9V0
    Conserved Domains (1) summary
    cd10484
    Location:128300
    EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6
  9. XM_011512707.3XP_011511009.1  ephrin type-A receptor 6 isoform X15

    UniProtKB/TrEMBL
    H0Y9V0
    Conserved Domains (1) summary
    cd10484
    Location:128300
    EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6
  10. XM_017006212.1XP_016861701.1  ephrin type-A receptor 6 isoform X5

    UniProtKB/Swiss-Prot
    D6RAL5, Q9UF33
  11. XM_017006213.2XP_016861702.1  ephrin type-A receptor 6 isoform X6

    UniProtKB/Swiss-Prot
    D6RAL5, Q9UF33
    Conserved Domains (8) summary
    cd09547
    Location:915978
    SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors
    smart00454
    Location:912979
    SAM; Sterile alpha motif
    cd00063
    Location:381488
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:580888
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:271365
    fn3; Fibronectin type III domain
    pfam07714
    Location:585884
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:508580
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1144
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
  12. XM_017006218.1XP_016861707.1  ephrin type-A receptor 6 isoform X10

  13. XM_017006217.2XP_016861706.1  ephrin type-A receptor 6 isoform X9

  14. XM_017006215.2XP_016861704.2  ephrin type-A receptor 6 isoform X8

  15. XM_017006216.2XP_016861705.2  ephrin type-A receptor 6 isoform X8

  16. XM_047448009.1XP_047303965.1  ephrin type-A receptor 6 isoform X12

RNA

  1. XR_001740110.2 RNA Sequence

  2. XR_924126.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    99518416..100468755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346273.1XP_054202248.1  ephrin type-A receptor 6 isoform X4

    UniProtKB/Swiss-Prot
    D6RAL5, Q9UF33
  2. XM_054346270.1XP_054202245.1  ephrin type-A receptor 6 isoform X1

    UniProtKB/Swiss-Prot
    D6RAL5, Q9UF33
  3. XM_054346271.1XP_054202246.1  ephrin type-A receptor 6 isoform X2

    UniProtKB/Swiss-Prot
    D6RAL5, Q9UF33
  4. XM_054346272.1XP_054202247.1  ephrin type-A receptor 6 isoform X3

    UniProtKB/Swiss-Prot
    D6RAL5, Q9UF33
  5. XM_054346276.1XP_054202251.1  ephrin type-A receptor 6 isoform X7

  6. XM_054346281.1XP_054202256.1  ephrin type-A receptor 6 isoform X11

    UniProtKB/TrEMBL
    E7EU71
  7. XM_054346283.1XP_054202258.1  ephrin type-A receptor 6 isoform X13

  8. XM_054346284.1XP_054202259.1  ephrin type-A receptor 6 isoform X14

    UniProtKB/TrEMBL
    H0Y9V0
  9. XM_054346285.1XP_054202260.1  ephrin type-A receptor 6 isoform X15

    UniProtKB/TrEMBL
    H0Y9V0
  10. XM_054346274.1XP_054202249.1  ephrin type-A receptor 6 isoform X5

    UniProtKB/Swiss-Prot
    D6RAL5, Q9UF33
  11. XM_054346275.1XP_054202250.1  ephrin type-A receptor 6 isoform X6

    UniProtKB/Swiss-Prot
    D6RAL5, Q9UF33
  12. XM_054346280.1XP_054202255.1  ephrin type-A receptor 6 isoform X10

  13. XM_054346279.1XP_054202254.1  ephrin type-A receptor 6 isoform X9

  14. XM_054346277.1XP_054202252.1  ephrin type-A receptor 6 isoform X8

  15. XM_054346278.1XP_054202253.1  ephrin type-A receptor 6 isoform X8

  16. XM_054346282.1XP_054202257.1  ephrin type-A receptor 6 isoform X12

RNA

  1. XR_008486700.1 RNA Sequence

  2. XR_008486701.1 RNA Sequence

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