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TUSC7 tumor suppressor candidate 7 [ Homo sapiens (human) ]

Gene ID: 285194, updated on 10-Oct-2023

Summary

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Official Symbol
TUSC7provided by HGNC
Official Full Name
tumor suppressor candidate 7provided by HGNC
Primary source
HGNC:HGNC:27701
See related
Ensembl:ENSG00000243197 MIM:616057; AllianceGenome:HGNC:27701
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LSAMPAS3; LINC00902; LSAMP-AS1; LSAMP-AS3; NCRNA00295
Expression
Restricted expression toward testis (RPKM 5.6) See more
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Genomic context

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See TUSC7 in Genome Data Viewer
Location:
3q13.31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (116709779..116717036)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (119429675..119436932)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (116428635..116435887)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 582, pseudogene Neighboring gene basic leucine zipper and W2 domains 1 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:116567636-116568270 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:116568271-116568906 Neighboring gene microRNA 4447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14622 Neighboring gene long intergenic non-protein coding RNA 901

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Serum level of lncRNA TUSC7 in patients with esophageal squamous cell carcinoma and its role in promoting tumor cell migration and invasion]. Zhao K, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2020 May 30. PMID 32897196, Free PMC Article
  2. Downregulation of long noncoding RNA TUSC7 promoted cell growth, invasion and migration through sponging with miR-616-5p/GSK3β pathway in ovarian cancer. Zhu LM, et al. Eur Rev Med Pharmacol Sci, 2020 Jul. PMID 32706063
  3. LncRNA LOC285194 modulates gastric carcinoma progression through activating Wnt/β-catenin signaling pathway. Zhong B, et al. Cancer Med, 2020 Mar. PMID 31991056, Free PMC Article
  4. Long non-coding RNA LOC285194 in cancer. Luo L, et al. Clin Chim Acta, 2020 Mar. PMID 31837299
  5. Decreased expression of long non-coding LOC285194 predicts tumour progression and poor prognosis of hepatocellular carcinoma after curative hepatectomy. Qiu J, et al. Postgrad Med J, 2020 Feb. PMID 31494574

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Proposed TUSC7/miR-211/Nurr1 ceRNET Might Potentially be Disturbed by a cer-SNP rs2615499 in Breast Cancer.
    Title: A Proposed TUSC7/miR-211/Nurr1 ceRNET Might Potentially be Disturbed by a cer-SNP rs2615499 in Breast Cancer.
  2. Long non-coding RNA TUSC7 suppressed colorectal cancer progression via regulation of miR-23b/PDE7A Axis.
    Title: Long non-coding RNA TUSC7 suppressed colorectal cancer progression via regulation of miR-23b/PDE7A Axis.
  3. LOC285194 inhibits proliferation of human keratinocytes through regulating miR-616/GATA3 pathway.
    Title: LOC285194 inhibits proliferation of human keratinocytes through regulating miR-616/GATA3 pathway.
  4. lncRNA TUSC7 inhibits osteosarcoma progression through the miR181a/RASSF6 axis.
    Title: lncRNA TUSC7 inhibits osteosarcoma progression through the miR‑181a/RASSF6 axis.
  5. Downregulation of long noncoding RNA TUSC7 promoted cell growth, invasion and migration through sponging with miR-616-5p/GSK3beta pathway in ovarian cancer.
    Title: Downregulation of long noncoding RNA TUSC7 promoted cell growth, invasion and migration through sponging with miR-616-5p/GSK3β pathway in ovarian cancer.
  6. LncRNA LOC285194 modulates gastric carcinoma progression through activating Wnt/beta-catenin signaling pathway.
    Title: LncRNA LOC285194 modulates gastric carcinoma progression through activating Wnt/β-catenin signaling pathway.
  7. Decreased expression of long non-coding LOC285194 predicts tumour progression and poor prognosis of hepatocellular carcinoma after curative hepatectomy.
    Title: Decreased expression of long non-coding LOC285194 predicts tumour progression and poor prognosis of hepatocellular carcinoma after curative hepatectomy.
  8. Long non-coding RNA LOC285194 in cancer.
    Title: Long non-coding RNA LOC285194 in cancer.
  9. Long non-coding RNA TUSC7 suppresses osteosarcoma by targeting miR-211.
    Title: Long non-coding RNA TUSC7 suppresses osteosarcoma by targeting miR-211.
  10. [Serum level of lncRNA TUSC7 in patients with esophageal squamous cell carcinoma and its role in promoting tumor cell migration and invasion].
    Title: [Serum level of lncRNA TUSC7 in patients with esophageal squamous cell carcinoma and its role in promoting tumor cell migration and invasion].
Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • LSAMP antisense RNA 3 (non-protein coding)
  • tumor suppressor candidate 7 (non-protein coding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_015391.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108687, AC108713
    Related
    ENST00000496242.6

  2. NR_186111.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108687, AC108713

  3. NR_186112.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108687, AC108713

  4. NR_186113.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108687, AC108713

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    116709779..116717036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    119429675..119436932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials