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CCDC150 coiled-coil domain containing 150 [ Homo sapiens (human) ]

Gene ID: 284992, updated on 3-Apr-2024

Summary

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Official Symbol
CCDC150provided by HGNC
Official Full Name
coiled-coil domain containing 150provided by HGNC
Primary source
HGNC:HGNC:26834
See related
Ensembl:ENSG00000144395 AllianceGenome:HGNC:26834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 4.2), bone marrow (RPKM 0.6) and 6 other tissues See more
Orthologs
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Genomic context

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Location:
2q33.1
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (196639715..196732806)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (197123662..197216860)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (197504439..197597530)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene uncharacterized LOC105373821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12205 Neighboring gene uncharacterized LOC105373823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16911 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:197504225-197504762 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:197504763-197505300 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:197517516-197518164 Neighboring gene small Cajal body-specific RNA 16 Neighboring gene uncharacterized LOC100130452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16914 Neighboring gene general transcription factor IIIC subunit 3 Neighboring gene chromosome 2 open reading frame 66

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Comprehensive Proteomic Analysis of PGC7-Interacting Proteins. Liu H, et al. J Proteome Res, 2017 Sep 1. PMID 28712289
  2. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Boldt K, et al. Nat Commun, 2016 May 13. PMID 27173435, Free PMC Article
  3. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article
  4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10202, FLJ38811, FLJ39660, MGC72171, DKFZp434P055

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
coiled-coil domain-containing protein 150

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080539.2 → NP_001074008.1  coiled-coil domain-containing protein 150 isoform 1

    See identical proteins and their annotated locations for NP_001074008.1

    Status: VALIDATED

    Source sequence(s)
    AC068544
    Consensus CDS
    CCDS46478.1
    UniProtKB/Swiss-Prot
    Q6P5U6, Q6P663, Q8N8V5, Q8NCX0
    Related
    ENSP00000373827.4, ENST00000389175.9
    Conserved Domains (2) summary
    COG1196
    Location:192 → 929
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19219
    Location:412 → 507
    DUF342; Protein of unknown function (DUF342)

  2. NM_001353339.2 → NP_001340268.1  coiled-coil domain-containing protein 150 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC068544, AK096979, AK302685
    UniProtKB/TrEMBL
    B4DZ03
    Conserved Domains (1) summary
    cl25732
    Location:2 → 678
    SMC_N; RecF/RecN/SMC N terminal domain

  3. NM_001353340.2 → NP_001340269.2  coiled-coil domain-containing protein 150 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC068544
    Related
    ENSP00000387257.1, ENST00000409270.5

  4. NM_001412753.1 → NP_001399682.1  coiled-coil domain-containing protein 150 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC068544

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    196639715..196732806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712438.4 → XP_006712501.1  coiled-coil domain-containing protein 150 isoform X1

    Conserved Domains (2) summary
    TIGR02168
    Location:328 → 1010
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl19219
    Location:412 → 507
    DUF342; Protein of unknown function (DUF342)

  2. XM_017003863.2 → XP_016859352.1  coiled-coil domain-containing protein 150 isoform X3

  3. XM_047443975.1 → XP_047299931.1  coiled-coil domain-containing protein 150 isoform X4

  4. XM_017003861.2 → XP_016859350.1  coiled-coil domain-containing protein 150 isoform X2

  5. XM_047443976.1 → XP_047299932.1  coiled-coil domain-containing protein 150 isoform X5

  6. XM_047443977.1 → XP_047299933.1  coiled-coil domain-containing protein 150 isoform X6

  7. XM_017003864.2 → XP_016859353.1  coiled-coil domain-containing protein 150 isoform X7

    Conserved Domains (1) summary
    TIGR02168
    Location:136 → 775
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  8. XM_047443978.1 → XP_047299934.1  coiled-coil domain-containing protein 150 isoform X9

  9. XM_011510987.3 → XP_011509289.1  coiled-coil domain-containing protein 150 isoform X8

    See identical proteins and their annotated locations for XP_011509289.1

    UniProtKB/TrEMBL
    B4DZ03
    Conserved Domains (1) summary
    cl25732
    Location:2 → 678
    SMC_N; RecF/RecN/SMC N terminal domain

  10. XM_017003866.2 → XP_016859355.1  coiled-coil domain-containing protein 150 isoform X8

    UniProtKB/TrEMBL
    B4DZ03
    Conserved Domains (1) summary
    cl25732
    Location:2 → 678
    SMC_N; RecF/RecN/SMC N terminal domain

  11. XM_011510988.3 → XP_011509290.1  coiled-coil domain-containing protein 150 isoform X10

    Conserved Domains (2) summary
    pfam07851
    Location:352 → 434
    TMPIT; TMPIT-like protein
    cl09914
    Location:248 → 388
    PHA_synth_III_E; Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    197123662..197216860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341467.1 → XP_054197442.1  coiled-coil domain-containing protein 150 isoform X1

  2. XM_054341469.1 → XP_054197444.1  coiled-coil domain-containing protein 150 isoform X3

  3. XM_054341470.1 → XP_054197445.1  coiled-coil domain-containing protein 150 isoform X4

  4. XM_054341468.1 → XP_054197443.1  coiled-coil domain-containing protein 150 isoform X2

  5. XM_054341473.1 → XP_054197448.1  coiled-coil domain-containing protein 150 isoform X7

  6. XM_054341476.1 → XP_054197451.1  coiled-coil domain-containing protein 150 isoform X9

  7. XM_054341471.1 → XP_054197446.1  coiled-coil domain-containing protein 150 isoform X5

  8. XM_054341472.1 → XP_054197447.1  coiled-coil domain-containing protein 150 isoform X6

  9. XM_054341475.1 → XP_054197450.1  coiled-coil domain-containing protein 150 isoform X8

    UniProtKB/TrEMBL
    B4DZ03

  10. XM_054341474.1 → XP_054197449.1  coiled-coil domain-containing protein 150 isoform X8

    UniProtKB/TrEMBL
    B4DZ03

  11. XM_054341477.1 → XP_054197452.1  coiled-coil domain-containing protein 150 isoform X10

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173466.1: Suppressed sequence

    Description
    NM_173466.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_173646.1: Suppressed sequence

    Description
    NM_173646.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NCX0.2 GenPept UniProtKB/Swiss-Prot:Q8NCX0

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