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LPAR4 lysophosphatidic acid receptor 4 [ Homo sapiens (human) ]

Gene ID: 2846, updated on 11-Apr-2024

Summary

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Official Symbol
LPAR4provided by HGNC
Official Full Name
lysophosphatidic acid receptor 4provided by HGNC
Primary source
HGNC:HGNC:4478
See related
Ensembl:ENSG00000147145 MIM:300086; AllianceGenome:HGNC:4478
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPA4; P2Y9; GPR23; P2RY9; P2Y5-LIKE
Summary
This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. [provided by RefSeq, Feb 2009]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See LPAR4 in Genome Data Viewer
Location:
Xq21.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (78747720..78758714)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (77184471..77195526)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (78003217..78014211)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985670 Neighboring gene retrotransposon Gag like 3 Neighboring gene phosphoribosyl pyrophosphate amidotransferase pseudogene 2 Neighboring gene ribosomal protein L7 pseudogene 54 Neighboring gene microRNA 4328

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation. Wu C, et al. Nat Cell Biol, 2023 Feb. PMID 36646789, Free PMC Article
  2. Lysophosphatidic acid receptor 4 signaling potentially modulates malignant behavior in human head and neck squamous cell carcinoma cells. Matayoshi S, et al. Int J Oncol, 2013 May. PMID 23467751, Free PMC Article
  3. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. Noguchi K, et al. J Biol Chem, 2003 Jul 11. PMID 12724320
  4. Cloning of a human heptahelical receptor closely related to the P2Y5 receptor. Janssens R, et al. Biochem Biophys Res Commun, 1997 Jul 9. PMID 9223435
  5. LPAR2 and LPAR4 are the Main Receptors Responsible for LPA Actions in Ovarian Endometriotic Cysts. Kowalczyk-Zieba I, et al. Reprod Sci, 2019 Jan. PMID 29621954

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation.
    Title: Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation.
  2. Potential genetic biomarkers predict adverse pregnancy outcome during early and mid-pregnancy in women with systemic lupus erythematosus.
    Title: Potential genetic biomarkers predict adverse pregnancy outcome during early and mid-pregnancy in women with systemic lupus erythematosus.
  3. Study shows that due to the high LPAR2 and LPAR4 transcript and protein expression in endometriotic ovarian cysts and positive correlations of both these receptors with the PR-B and ERbeta, respectively, those receptors seem to be the most promising predictors of the endometriotic cysts.
    Title: LPAR2 and LPAR4 are the Main Receptors Responsible for LPA Actions in Ovarian Endometriotic Cysts.
  4. Mutation in LPAR4 gene is associated with papillary thyroid carcinoma.
    Title: Whole exome sequencing identifies lncRNA GAS8-AS1 and LPAR4 as novel papillary thyroid carcinoma driver alternations.
  5. These results suggest that the diverse roles of LPA4, LPA5 and LPA6 are involved in the activation of tumor progression in pancreatic cancer cells.
    Title: Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells.
  6. Our data suggest that LPA4 signaling potentially modulates malignant behavior of SQ-20B cells.
    Title: Lysophosphatidic acid receptor 4 signaling potentially modulates malignant behavior in human head and neck squamous cell carcinoma cells.
  7. LPA4 gene mutation may play some role in the pathogenesis of colon cancer.
    Title: Differential expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in human colon cancer cells.
  8. LPA4 and LPA5 receptors induce osteoblastic differentiation of human mesenchymal stem cells
    Title: LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4.
  9. Data show that CLL cells express LPA receptors LPA(1-5) and VEGF receptors, and the plasma levels of VEGF are elevated in CLL patients.
    Title: Lysophosphatidic acid receptor expression in chronic lymphocytic leukemia leads to cell survival mediated though vascular endothelial growth factor expression.
  10. identified as the fourth lysophosphatidic acid (LPA) receptor; shares only 20-24% amino acid identities with Edg-2/LPA1, Edg-4/LPA2, and Edg-7/LPA3, and phylogenetic analysis also shows that p2y9/GPR23 is far distant from the Edg family
    Title: Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lysophosphatidic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables lysophosphatidic acid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
lysophosphatidic acid receptor 4
Names
G-protein coupled receptor 23
LPA receptor 4
LPA-4
P2Y purinoceptor 9
P2Y5-like receptor
purinergic receptor 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013242.1 RefSeqGene

    Range
    5012..16006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001278000.3 → NP_001264929.1  lysophosphatidic acid receptor 4

    See identical proteins and their annotated locations for NP_001264929.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL590083
    Consensus CDS
    CCDS14441.1
    UniProtKB/Swiss-Prot
    B2RAC7, O15132, Q502U9, Q6NSP5, Q99677
    Related
    ENSP00000478261.1, ENST00000614823.5
    Conserved Domains (2) summary
    pfam00001
    Location:57 → 311
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:51 → 165
    7tm_4; Olfactory receptor

  2. NM_005296.3 → NP_005287.1  lysophosphatidic acid receptor 4

    See identical proteins and their annotated locations for NP_005287.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks alternate exons in the 5'UTR. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA424772, AK314134, AL590083, BM973092, BX100826, U90322
    Consensus CDS
    CCDS14441.1
    UniProtKB/Swiss-Prot
    B2RAC7, O15132, Q502U9, Q6NSP5, Q99677
    Related
    ENSP00000408205.2, ENST00000435339.3
    Conserved Domains (2) summary
    pfam00001
    Location:57 → 311
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:51 → 165
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    78747720..78758714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442014.1 → XP_047297970.1  lysophosphatidic acid receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

  2. XM_047442015.1 → XP_047297971.1  lysophosphatidic acid receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

  3. XM_017029437.2 → XP_016884926.1  lysophosphatidic acid receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAC7, O15132, Q502U9, Q6NSP5, Q99677
    Conserved Domains (2) summary
    pfam00001
    Location:57 → 311
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:51 → 165
    7tm_4; Olfactory receptor

  4. XM_047442013.1 → XP_047297969.1  lysophosphatidic acid receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

  5. XM_047442012.1 → XP_047297968.1  lysophosphatidic acid receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

  6. XM_047442011.1 → XP_047297967.1  lysophosphatidic acid receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

  7. XM_006724639.4 → XP_006724702.1  lysophosphatidic acid receptor 4 isoform X1

    See identical proteins and their annotated locations for XP_006724702.1

    UniProtKB/Swiss-Prot
    B2RAC7, O15132, Q502U9, Q6NSP5, Q99677
    Conserved Domains (2) summary
    pfam00001
    Location:57 → 311
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:51 → 165
    7tm_4; Olfactory receptor

  8. XM_017029438.2 → XP_016884927.1  lysophosphatidic acid receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAC7, O15132, Q502U9, Q6NSP5, Q99677
    Conserved Domains (2) summary
    pfam00001
    Location:57 → 311
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:51 → 165
    7tm_4; Olfactory receptor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    77184471..77195526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326881.1 → XP_054182856.1  lysophosphatidic acid receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

  2. XM_054326883.1 → XP_054182858.1  lysophosphatidic acid receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

  3. XM_054326876.1 → XP_054182851.1  lysophosphatidic acid receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

  4. XM_054326880.1 → XP_054182855.1  lysophosphatidic acid receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

  5. XM_054326878.1 → XP_054182853.1  lysophosphatidic acid receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

  6. XM_054326877.1 → XP_054182852.1  lysophosphatidic acid receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

  7. XM_054326879.1 → XP_054182854.1  lysophosphatidic acid receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAC7, O15132, Q502U9, Q6NSP5, Q99677

  8. XM_054326882.1 → XP_054182857.1  lysophosphatidic acid receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    B2RAC7, O15132, Q502U9, Q6NSP5, Q99677
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99677.1 GenPept UniProtKB/Swiss-Prot:Q99677

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