U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TMEM145 transmembrane protein 145 [ Homo sapiens (human) ]

Gene ID: 284339, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
TMEM145provided by HGNC
Official Full Name
transmembrane protein 145provided by HGNC
Primary source
HGNC:HGNC:26912
See related
Ensembl:ENSG00000167619 AllianceGenome:HGNC:26912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 11.6), adrenal (RPKM 1.6) and 1 other tissue See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
19q13.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42313309..42325064)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45132694..45144449)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42817461..42829216)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14711 Neighboring gene ZFP161 motif-containing MPRA enhancer 284/285 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:42784339-42784844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42785857-42786361 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:42787942-42788116 Neighboring gene capicua transcriptional repressor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42794166-42795066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14713 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42806463-42807117 Neighboring gene platelet activating factor acetylhydrolase 1b catalytic subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10707 Neighboring gene proline rich 19 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42818801-42819301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10711 Neighboring gene multiple EGF like domains 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42853955-42854456 Neighboring gene microRNA 8077 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42866515-42867014 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42873179-42874132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10712 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10713 Neighboring gene cornifelin

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A. Hoel CM, et al. Elife, 2022 Nov 14. PMID 36373655, Free PMC Article
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Otsuki T, et al. DNA Res, 2005. PMID 16303743
  3. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Clone Names

  • FLJ90805

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in response to pheromone IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transmembrane protein 145

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366910.1 → NP_001353839.1  transmembrane protein 145 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC024078
    Consensus CDS
    CCDS92635.1
    UniProtKB/TrEMBL
    A0A5F9ZH48
    Related
    ENSP00000500040.1, ENST00000673187.1
    Conserved Domains (1) summary
    pfam10192
    Location:157 → 411
    GpcrRhopsn4; Rhodopsin-like GPCR transmembrane domain

  2. NM_173633.3 → NP_775904.2  transmembrane protein 145 isoform 2 precursor

    See identical proteins and their annotated locations for NP_775904.2

    Status: VALIDATED

    Source sequence(s)
    AC024078, AK075286, DA694683
    Consensus CDS
    CCDS12603.1
    UniProtKB/Swiss-Prot
    Q8NBT3
    UniProtKB/TrEMBL
    A0A5F9ZGX1
    Related
    ENSP00000301204.2, ENST00000301204.8
    Conserved Domains (1) summary
    pfam10192
    Location:143 → 397
    GpcrRhopsn4; Rhodopsin-like GPCR transmembrane domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    42313309..42325064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526791.4 → XP_011525093.1  transmembrane protein 145 isoform X1

    Conserved Domains (2) summary
    pfam10192
    Location:143 → 397
    GpcrRhopsn4; Rhodopsin-like GPCR transmembrane domain
    pfam17037
    Location:418 → 546
    CBP_BcsO; Cellulose biosynthesis protein BcsO

  2. XM_011526792.2 → XP_011525094.1  transmembrane protein 145 isoform X2

    Conserved Domains (1) summary
    cl21735
    Location:157 → 314
    Lung_7-TM_R; Lung seven transmembrane receptor

  3. XM_047438636.1 → XP_047294592.1  transmembrane protein 145 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    45132694..45144449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320623.1 → XP_054176598.1  transmembrane protein 145 isoform X1

  2. XM_054320624.1 → XP_054176599.1  transmembrane protein 145 isoform X2

  3. XM_054320625.1 → XP_054176600.1  transmembrane protein 145 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NBT3.2 GenPept UniProtKB/Swiss-Prot:Q8NBT3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous