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SLC26A11 solute carrier family 26 member 11 [ Homo sapiens (human) ]

Gene ID: 284129, updated on 11-Apr-2024

Summary

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Official Symbol
SLC26A11provided by HGNC
Official Full Name
solute carrier family 26 member 11provided by HGNC
Primary source
HGNC:HGNC:14471
See related
Ensembl:ENSG00000181045 MIM:610117; AllianceGenome:HGNC:14471
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in adrenal (RPKM 8.3), spleen (RPKM 6.4) and 25 other tissues See more
Orthologs
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Genomic context

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See SLC26A11 in Genome Data Viewer
Location:
17q25.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (80220427..80253500)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (81120848..81153937)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (78194226..78227299)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:78120154-78120868 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:78120869-78121581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78121582-78122295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78122296-78123008 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:78126203-78126704 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:78126705-78127204 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:78129355-78129892 Neighboring gene eukaryotic translation initiation factor 4A3 Neighboring gene Sharpr-MPRA regulatory region 5287 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:78151904-78153103 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78163065-78163581 Neighboring gene caspase recruitment domain family member 14 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:78178385-78179584 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:78183891-78184046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12929 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78195951-78196788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78196789-78197626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78200105-78200606 Neighboring gene N-sulfoglucosamine sulfohydrolase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78209849-78210638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78210639-78211426 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78227308-78228024 Neighboring gene SLC26A11-RNF213 intergenic CAGE-defined mid-level expression enhancer Neighboring gene CRISPRi-validated cis-regulatory element chr17.5742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9104 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9105 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9106 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78237270-78237826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78247837-78248435 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78251821-78252439 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78258533-78259093 Neighboring gene ring finger protein 213 Neighboring gene RNF213 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:78345568-78346767 Neighboring gene MPRA-validated peak3024 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78354122-78354622 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:78359110-78360309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78369069-78369570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78371216-78371723 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78371724-78372230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12935 Neighboring gene microRNA 4730 Neighboring gene endonuclease V

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Renal physiology of SLC26 anion exchangers. Sindić A, et al. Curr Opin Nephrol Hypertens, 2007 Sep. PMID 17693766
  2. SLC26 chloride/base exchangers in the kidney in health and disease. Soleimani M, et al. Semin Nephrol, 2006 Sep. PMID 17071331
  3. Molecular and functional characterization of SLC26A11, a sodium-independent sulfate transporter from high endothelial venules. Vincourt JB, et al. FASEB J, 2003 May. PMID 12626430
  4. The proteome of lysosomes. Schröder BA, et al. Proteomics, 2010 Nov. PMID 20957757
  5. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. Palmieri M, et al. Hum Mol Genet, 2011 Oct 1. PMID 21752829

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLC26A11 protein localizes in lysosomes in HeLa cells
    Title: Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC46523

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chloride channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables chloride:bicarbonate antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables monoatomic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables secondary active sulfate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfate transmembrane transporter activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport TAS
Traceable Author Statement
more info
  
involved_in oxalate transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
sodium-independent sulfate anion transporter
Names
solute carrier family 26 (anion exchanger), member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166347.2 → NP_001159819.1  sodium-independent sulfate anion transporter

    See identical proteins and their annotated locations for NP_001159819.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AI963799, AK075248, AK315132, BC035900, DA290933
    Consensus CDS
    CCDS11771.2
    UniProtKB/Swiss-Prot
    B2RCI7, Q86VX1, Q86WA9, Q86YX7, Q8IV11, Q8N2I1, Q8NG03
    Related
    ENSP00000355384.3, ENST00000361193.8
    Conserved Domains (3) summary
    cd07042
    Location:470 → 564
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:35 → 559
    sulP; high affinity sulphate transporter 1
    cl06211
    Location:221 → 334
    DUF1341; Protein of unknown function (DUF1341)

  2. NM_001166348.2 → NP_001159820.1  sodium-independent sulfate anion transporter

    See identical proteins and their annotated locations for NP_001159820.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AI963799, AK075248, AL833468, DA290933
    Consensus CDS
    CCDS11771.2
    UniProtKB/Swiss-Prot
    B2RCI7, Q86VX1, Q86WA9, Q86YX7, Q8IV11, Q8N2I1, Q8NG03
    Related
    ENSP00000440724.2, ENST00000546047.6
    Conserved Domains (3) summary
    cd07042
    Location:470 → 564
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:35 → 559
    sulP; high affinity sulphate transporter 1
    cl06211
    Location:221 → 334
    DUF1341; Protein of unknown function (DUF1341)

  3. NM_001166349.2 → NP_001159821.1  sodium-independent sulfate anion transporter

    See identical proteins and their annotated locations for NP_001159821.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AF331524, AF345195, AI963799, AK075248, DA290933
    Consensus CDS
    CCDS11771.2
    UniProtKB/Swiss-Prot
    B2RCI7, Q86VX1, Q86WA9, Q86YX7, Q8IV11, Q8N2I1, Q8NG03
    Related
    ENSP00000459470.1, ENST00000572725.5
    Conserved Domains (3) summary
    cd07042
    Location:470 → 564
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:35 → 559
    sulP; high affinity sulphate transporter 1
    cl06211
    Location:221 → 334
    DUF1341; Protein of unknown function (DUF1341)

  4. NM_173626.4 → NP_775897.3  sodium-independent sulfate anion transporter

    See identical proteins and their annotated locations for NP_775897.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC123764, AI963799, AK075248, DA290933
    Consensus CDS
    CCDS11771.2
    UniProtKB/Swiss-Prot
    B2RCI7, Q86VX1, Q86WA9, Q86YX7, Q8IV11, Q8N2I1, Q8NG03
    Related
    ENSP00000403998.3, ENST00000411502.7
    Conserved Domains (3) summary
    cd07042
    Location:470 → 564
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:35 → 559
    sulP; high affinity sulphate transporter 1
    cl06211
    Location:221 → 334
    DUF1341; Protein of unknown function (DUF1341)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    80220427..80253500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435806.1 → XP_047291762.1  sodium-independent sulfate anion transporter isoform X2

    UniProtKB/Swiss-Prot
    B2RCI7, Q86VX1, Q86WA9, Q86YX7, Q8IV11, Q8N2I1, Q8NG03

  2. XM_006721833.3 → XP_006721896.1  sodium-independent sulfate anion transporter isoform X1

    Conserved Domains (3) summary
    cd07042
    Location:494 → 588
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:35 → 583
    sulP; high affinity sulphate transporter 1
    cl06211
    Location:245 → 358
    DUF1341; Protein of unknown function (DUF1341)

  3. XM_017024507.2 → XP_016879996.1  sodium-independent sulfate anion transporter isoform X1

    Conserved Domains (3) summary
    cd07042
    Location:494 → 588
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:35 → 583
    sulP; high affinity sulphate transporter 1
    cl06211
    Location:245 → 358
    DUF1341; Protein of unknown function (DUF1341)

  4. XM_017024505.2 → XP_016879994.2  sodium-independent sulfate anion transporter isoform X1

  5. XM_047435808.1 → XP_047291764.1  sodium-independent sulfate anion transporter isoform X4

  6. XM_047435807.1 → XP_047291763.1  sodium-independent sulfate anion transporter isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    81120848..81153937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315800.1 → XP_054171775.1  sodium-independent sulfate anion transporter isoform X2

    UniProtKB/Swiss-Prot
    B2RCI7, Q86VX1, Q86WA9, Q86YX7, Q8IV11, Q8N2I1, Q8NG03

  2. XM_054315798.1 → XP_054171773.1  sodium-independent sulfate anion transporter isoform X1

  3. XM_054315799.1 → XP_054171774.1  sodium-independent sulfate anion transporter isoform X1

  4. XM_054315797.1 → XP_054171772.1  sodium-independent sulfate anion transporter isoform X1

  5. XM_054315802.1 → XP_054171777.1  sodium-independent sulfate anion transporter isoform X4

  6. XM_054315801.1 → XP_054171776.1  sodium-independent sulfate anion transporter isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86WA9.2 GenPept UniProtKB/Swiss-Prot:Q86WA9

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