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CLEC18C C-type lectin domain family 18 member C [ Homo sapiens (human) ]

Gene ID: 283971, updated on 3-Apr-2024

Summary

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Official Symbol
CLEC18Cprovided by HGNC
Official Full Name
C-type lectin domain family 18 member Cprovided by HGNC
Primary source
HGNC:HGNC:28538
See related
Ensembl:ENSG00000157335 MIM:616573; AllianceGenome:HGNC:28538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRCL; MRCL3
Summary
Enables polysaccharide binding activity. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and endosome. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney (RPKM 27.4) and testis (RPKM 7.1) See more
Orthologs
all
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Genomic context

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Location:
16q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (70173787..70186895)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (75983920..75997950)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70207690..70220798)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr16:70121188-70121409 Neighboring gene ribosomal protein S10 pseudogene 24 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11049 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:70148769-70149711 Neighboring gene pyruvate dehydrogenase phosphatase regulatory subunit Neighboring gene uncharacterized LOC400541 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70200631-70201130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:70221261-70222190 Neighboring gene uncharacterized LOC105371328 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:70238115-70238280 Neighboring gene small nucleolar RNA U13 Neighboring gene SMG1 pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity. Huang YL, et al. J Biol Chem, 2015 Aug 28. PMID 26170455, Free PMC Article
  2. The C-type lectin-like domain superfamily. Zelensky AN, et al. FEBS J, 2005 Dec. PMID 16336259
  3. Toward an understanding of the protein interaction network of the human liver. Wang J, et al. Mol Syst Biol, 2011 Oct 11. PMID 21988832, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC34761

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables polysaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polysaccharide binding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
 PubMed 
located_in endosome TAS
Traceable Author Statement
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
C-type lectin domain family 18 member C
Names
mannose receptor-like 3
mannose receptor-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173619.4 → NP_775890.2  C-type lectin domain family 18 member C precursor

    See identical proteins and their annotated locations for NP_775890.2

    Status: VALIDATED

    Source sequence(s)
    AC009060
    Consensus CDS
    CCDS32473.1
    UniProtKB/Swiss-Prot
    Q8IUW8, Q8NCF0
    UniProtKB/TrEMBL
    F5H550
    Related
    ENSP00000444875.2, ENST00000541793.7
    Conserved Domains (2) summary
    cd00037
    Location:310 → 434
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd05380
    Location:50 → 183
    SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    70173787..70186895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433992.1 → XP_047289948.1  C-type lectin domain family 18 member C isoform X2

  2. XM_047433991.1 → XP_047289947.1  C-type lectin domain family 18 member C isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    75983920..75997950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380143.1 → XP_054236118.1  C-type lectin domain family 18 member C isoform X3

  2. XM_054380146.1 → XP_054236121.1  C-type lectin domain family 18 member C isoform X5

  3. XM_054380147.1 → XP_054236122.1  C-type lectin domain family 18 member C isoform X6

  4. XM_054380144.1 → XP_054236119.1  C-type lectin domain family 18 member C isoform X4

  5. XM_054380145.1 → XP_054236120.1  C-type lectin domain family 18 member C isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NCF0.2 GenPept UniProtKB/Swiss-Prot:Q8NCF0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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