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HERC2P3 HERC2 pseudogene 3 [ Homo sapiens (human) ]

Gene ID: 283755, updated on 23-Nov-2023

Summary

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Official Symbol
HERC2P3provided by HGNC
Official Full Name
HERC2 pseudogene 3provided by HGNC
Primary source
HGNC:HGNC:4871
See related
Ensembl:ENSG00000290376 AllianceGenome:HGNC:4871
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D15F37S4
Summary
Predicted to enable metal ion binding activity and ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 21.2), urinary bladder (RPKM 17.1) and 25 other tissues See more
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Genomic context

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Location:
15q11.1-q11.2
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (20408396..20506180, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (18320251..18417997, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (20613649..20711433, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:20500417-20500916 Neighboring gene uncharacterized LOC124903442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:20507209-20507708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:20509508-20510385 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:20510874-20511842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:20511843-20512809 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:20545365-20545888 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:20545889-20546410 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:20546411-20546934 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:20546935-20547456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:20547457-20547980 Neighboring gene uncharacterized LOC124903613 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:20707920-20708594 Neighboring gene E3 ubiquitin-protein ligase HERC2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:20736451-20736951 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:20738609-20739110 Neighboring gene golgin A6 family like 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A putative gene family in 15q11-13 and 16p11.2: possible implications for Prader-Willi and Angelman syndromes. Buiting K, et al. Proc Natl Acad Sci U S A, 1992 Jun 15. PMID 1608955, Free PMC Article
  2. Expressed copies of the MN7 (D15F37) gene family map close to the common deletion breakpoints in the Prader-Willi/Angelman syndromes. Buiting K, et al. Cytogenet Cell Genet, 1998. PMID 9730612
  3. The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities. Ji Y, et al. Hum Mol Genet, 1999 Mar. PMID 9949213
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197
  5. Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy. Sun X, et al. Acta Pharm Sin B, 2022 Feb. PMID 35256949, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • hect domain and RLD 2 pseudogene 3

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_036432.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC026495, AC138748, BC094757
    Related
    ENST00000430598.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    20408396..20506180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160017.1 Reference GRCh38.p14 PATCHES

    Range
    650178..747905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    18320251..18417997 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_008269.2: Suppressed sequence

    Description
    NG_008269.2: This RefSeq was permanently suppressed because it is now thought that this pseudogene is transcribed.

  2. NG_025280.1: Suppressed sequence

    Description
    NG_025280.1: This RefSeq was permanently suppressed because it is now thought that this pseudogene is transcribed.

  3. NM_001024682.1: Suppressed sequence

    Description
    NM_001024682.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BVR0.2 GenPept UniProtKB/Swiss-Prot:Q9BVR0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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Research Materials
Miscellaneous