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GPR12 G protein-coupled receptor 12 [ Homo sapiens (human) ]

Gene ID: 2835, updated on 5-Mar-2024

Summary

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Official Symbol
GPR12provided by HGNC
Official Full Name
G protein-coupled receptor 12provided by HGNC
Primary source
HGNC:HGNC:4466
See related
Ensembl:ENSG00000132975 MIM:600752; AllianceGenome:HGNC:4466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPCR12; GPCR21; PPP1R84
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and cellular calcium ion homeostasis. Predicted to be integral component of plasma membrane. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 3.0) and salivary gland (RPKM 0.6) See more
Orthologs
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Genomic context

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Location:
13q12.13
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (26755200..26760786, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (25969158..25974743, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (27329337..27334923, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene WASP family member 3 Neighboring gene RPS3A pseudogene 44 Neighboring gene NANOG hESC enhancer GRCh37_chr13:27232594-27233188 Neighboring gene uncharacterized LOC107984597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:27269807-27270328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7493 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:27316809-27317475 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:27359105-27359720 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5190 Neighboring gene FGFR1 oncogene partner 2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:27541783-27542642 Neighboring gene ribosomal protein S21 pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structural insight into the constitutive activity of human orphan receptor GPR12. Li H, et al. Sci Bull (Beijing), 2023 Jan 15. PMID 36593162
  2. GPR12 inhibits migration and promotes apoptosis in esophageal cancer and hypopharyngeal cancer cells. Zhang M, et al. Thorac Cancer, 2021 May. PMID 33742771, Free PMC Article
  3. Cannabidiol, a novel inverse agonist for GPR12. Brown KJ, et al. Biochem Biophys Res Commun, 2017 Nov 4. PMID 28888984, Free PMC Article
  4. Involvement of GPR12 in the regulation of cell proliferation and survival. Lu X, et al. Mol Cell Biochem, 2012 Jul. PMID 22430950
  5. Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. Uhlenbrock K, et al. Cell Physiol Biochem, 2003. PMID 12649592

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exosomal miR-105-5p derived from bladder cancer stem cells targets for GPR12 to promote the malignancy of bladder cancer.
    Title: Exosomal miR-105-5p derived from bladder cancer stem cells targets for GPR12 to promote the malignancy of bladder cancer.
  2. Structural insight into the constitutive activity of human orphan receptor GPR12.
    Title: Structural insight into the constitutive activity of human orphan receptor GPR12.
  3. GPR12 inhibits migration and promotes apoptosis in esophageal cancer and hypopharyngeal cancer cells.
    Title: GPR12 inhibits migration and promotes apoptosis in esophageal cancer and hypopharyngeal cancer cells.
  4. Since we have demonstrated that CBD is an inverse agonist for GPR12, this provides novel mechanism of action for CBD, and an initial chemical scaffold upon which highly potent and efficacious agents acting on GPR12 may be developed with the ultimate goal of blocking cancer metastasis.
    Title: Cannabidiol, a novel inverse agonist for GPR12.
  5. GPR12 may play a role in cell proliferation and survival
    Title: Involvement of GPR12 in the regulation of cell proliferation and survival.
  6. control of gene expression in vascular endothelial cells in the presence of fluid shear stress and classifies it as a sphingosine 1-phosphate receptor
    Title: Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ18149, FLJ97704, MGC138349, MGC138351

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylcholine binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 12
Names
protein phosphatase 1, regulatory subunit 84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005288.4 → NP_005279.1  G-protein coupled receptor 12

    See identical proteins and their annotated locations for NP_005279.1

    Status: VALIDATED

    Source sequence(s)
    AK290220, AL159978, AW015633
    Consensus CDS
    CCDS9319.1
    UniProtKB/Swiss-Prot
    P47775, Q5T8P3
    UniProtKB/TrEMBL
    A8K2F5, Q6NWS7, Q6NWS8
    Related
    ENSP00000384932.3, ENST00000405846.5
    Conserved Domains (1) summary
    cd15961
    Location:45 → 312
    7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    26755200..26760786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266360.3 → XP_005266417.1  G-protein coupled receptor 12 isoform X1

    See identical proteins and their annotated locations for XP_005266417.1

    UniProtKB/TrEMBL
    B4DG25
    Conserved Domains (1) summary
    pfam00001
    Location:1 → 142
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    25969158..25974743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374470.1 → XP_054230445.1  G-protein coupled receptor 12 isoform X1

    UniProtKB/TrEMBL
    B4DG25
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47775.1 GenPept UniProtKB/Swiss-Prot:P47775

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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