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NME2P1 NME2 pseudogene 1 [ Homo sapiens (human) ]

Gene ID: 283458, updated on 7-Jan-2024

Summary

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Official Symbol
NME2P1provided by HGNC
Official Full Name
NME2 pseudogene 1provided by HGNC
Primary source
HGNC:HGNC:31358
See related
AllianceGenome:HGNC:31358
Gene type
pseudo
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in regulation of apoptotic process. Located in extracellular exosome and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
12q24.23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (120282218..120282856)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (120269390..120270028)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120720021..120720659)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903034 Neighboring gene paxillin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4943 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120662858-120663539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7135 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120664223-120664903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4944 Neighboring gene hESC enhancers GRCh37_chr12:120667255-120667814 and GRCh37_chr12:120667815-120668374 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:120668816-120670015 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120670055-120670614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120671735-120672294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120676424-120677054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120682649-120683475 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7137 Neighboring gene ribosomal protein S20 pseudogene 31 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120697989-120698555 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120717966-120718466 Neighboring gene hESC enhancers GRCh37_chr12:120727716-120728708 and GRCh37_chr12:120728709-120729700 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120730693-120731684 Neighboring gene RNA, U4 small nuclear 2 Neighboring gene sirtuin 4 Neighboring gene RNA, U4 small nuclear 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the human nm23-H2 promoter region and localization of the microsatellite D17S396. Seifert M, et al. Biochem Biophys Res Commun, 1995 Oct 24. PMID 7488060
  2. Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1. Dooley S, et al. Hum Genet, 1994 Jan. PMID 8270257
  3. PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Lau E, et al. Cell, 2012 Feb 3. PMID 22304920, Free PMC Article
  4. Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation. Raisner R, et al. Cell Rep, 2018 Aug 14. PMID 30110629
  5. IKK-Mediated Regulation of the COP9 Signalosome via Phosphorylation of CSN5. Zhang J, et al. J Proteome Res, 2020 Mar 6. PMID 31950832, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • NME/NM23 nucleoside diphosphate kinase 2 pseudogene 1
  • non-metastatic cells 2, protein (NM23B) expressed in, pseudogene 1
  • nucleoside diphosphate kinase B-like pseudogene

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in UTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in nucleus HDA PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027861.5 

    Range
    101..739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    120282218..120282856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    120269390..120270028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_176827.2: Suppressed sequence

    Description
    NM_176827.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

  2. NR_001577.1: Suppressed sequence

    Description
    NR_001577.1: This RefSeq was permanently suppressed because there is insufficient evidence that this locus is transcribed.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60361.1 GenPept UniProtKB/Swiss-Prot:O60361

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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Miscellaneous