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CSNK2A3 casein kinase 2 alpha 3 [ Homo sapiens (human) ]

Gene ID: 283106, updated on 7-Apr-2024

Summary

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Official Symbol
CSNK2A3provided by HGNC
Official Full Name
casein kinase 2 alpha 3provided by HGNC
Primary source
HGNC:HGNC:2458
See related
Ensembl:ENSG00000254598 AllianceGenome:HGNC:2458
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSNK2A1P
Summary
This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012]
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Genomic context

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Location:
11p15.4
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (11351942..11353250, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (11440863..11442171, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (11373489..11374797, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902631 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:11278996-11279162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:11286683-11287184 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:11301387-11302362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:11312119-11312618 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 18 Neighboring gene uncharacterized LOC124902633 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:11400009-11400508 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:11425327-11426526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:11430413-11430914 Neighboring gene uncharacterized LOC107983976 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_18862 Neighboring gene NANOG hESC enhancer GRCh37_chr11:11530882-11531383 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:11559636-11560464 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_18916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4454 Neighboring gene uncharacterized LOC124902632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:11591851-11592350

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Assignment of casein kinase 2 alpha sequences to two different human chromosomes. Boldyreff B, et al. Hum Genet, 1992 Apr. PMID 1577469

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
casein kinase II subunit alpha 3
Names
CK II alpha 3
casein kinase 2, alpha 1 polypeptide pseudogene
casein kinase 2, alpha 3 polypeptide
casein kinase II alpha 1 polypeptide pseudogene
NP_001243615.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256686.2 → NP_001243615.1  casein kinase II subunit alpha 3

    See identical proteins and their annotated locations for NP_001243615.1

    Status: VALIDATED

    Source sequence(s)
    AC023946
    Consensus CDS
    CCDS59224.1
    UniProtKB/Swiss-Prot
    Q8NEV1
    UniProtKB/TrEMBL
    B2R6D7, B5BUH5
    Related
    ENSP00000473553.1, ENST00000528848.3
    Conserved Domains (3) summary
    cd14132
    Location:20 → 325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    pfam00069
    Location:39 → 324
    Pkinase; Protein kinase domain
    pfam12484
    Location:332 → 389
    PE_PPE_C; Polymorphic PE/PPE proteins C terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    11351942..11353250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    11440863..11442171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_002207.1: Suppressed sequence

    Description
    NR_002207.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NEV1.2 GenPept UniProtKB/Swiss-Prot:Q8NEV1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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