FUOM fucose mutarotase [Homo sapiens (human)] - Gene

Summary

Official Symbol: FUOMprovided by HGNC
Official Full Name: fucose mutarotaseprovided by HGNC
Primary source: HGNC:HGNC:24733
See related: Ensembl:ENSG00000148803 MIM:617725; AllianceGenome:HGNC:24733
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FUCU; FucM; C10orf125
Summary: Predicted to enable L-fucose mutarotase activity and fucose binding activity. Predicted to be involved in fucose metabolic process and fucosylation. Predicted to act upstream of or within female mating behavior and negative regulation of neuron differentiation. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver (RPKM 9.1), duodenum (RPKM 5.8) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q26.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (133352773..133358019, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (134310274..134313135, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (135168662..135171523, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables L-fucose mutarotase activity	ISS Inferred from Sequence or Structural Similarity more info
enables fucose binding	IBA Inferred from Biological aspect of Ancestor more info
enables fucose binding	ISS Inferred from Sequence or Structural Similarity more info
enables racemase and epimerase activity, acting on carbohydrates and derivatives	IBA Inferred from Biological aspect of Ancestor more info
enables racemase and epimerase activity, acting on carbohydrates and derivatives	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in fucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fucose metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in fucosylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: fucose mutarotase

Names: protein fucU homolog

NP_001091953.1

EC 5.1.3.29

NP_001288756.1

EC 5.1.3.29

NP_001288757.1

EC 5.1.3.29

NP_940874.2

EC 5.1.3.29

XP_011537972.1

EC 5.1.3.29

XP_011537973.1

EC 5.1.3.29

XP_011537974.1

EC 5.1.3.29

XP_011537975.1

EC 5.1.3.29

XP_011537976.1

EC 5.1.3.29

XP_011537977.1

EC 5.1.3.29

XP_047281057.1

EC 5.1.3.29

XP_047281058.1

EC 5.1.3.29

XP_047281059.1

EC 5.1.3.29

XP_047281060.1

EC 5.1.3.29

XP_047281061.1

EC 5.1.3.29

XP_054221594.1

EC 5.1.3.29

XP_054221595.1

EC 5.1.3.29

XP_054221596.1

EC 5.1.3.29

XP_054221597.1

EC 5.1.3.29

XP_054221598.1

EC 5.1.3.29

XP_054221599.1

EC 5.1.3.29

XP_054221600.1

EC 5.1.3.29

XP_054221601.1

EC 5.1.3.29

XP_054221602.1

EC 5.1.3.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098483.3 → NP_001091953.1 fucose mutarotase isoform 1

See identical proteins and their annotated locations for NP_001091953.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AI333356, HY163253

Consensus CDS

CCDS44499.1

UniProtKB/Swiss-Prot

A1L300, A2VDF0, Q5VWY2, Q5VWY3, Q6ZPD2

UniProtKB/TrEMBL

X6RK00

Related

ENSP00000278025.5, ENST00000278025.9

Conserved Domains (1) summary

cl00809
Location:4 → 147

RbsD_FucU; RbsD / FucU transport protein family
NM_001301827.2 → NP_001288756.1 fucose mutarotase isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.

Source sequence(s)

AI333356, AK129527, BM009909

UniProtKB/TrEMBL

X6RK00

Related

ENSP00000413379.2, ENST00000447176.5

Conserved Domains (1) summary

cl00809
Location:4 → 124

RbsD_FucU; RbsD / FucU transport protein family
NM_001301828.2 → NP_001288757.1 fucose mutarotase isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice site in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AI333356, AK129527, BU849497

Consensus CDS

CCDS76364.1

UniProtKB/TrEMBL

X6R6T9, X6RK00

Related

ENST00000465384.5

Conserved Domains (1) summary

cl00809
Location:3 → 102

RbsD_FucU; RbsD / FucU transport protein family
NM_198472.3 → NP_940874.2 fucose mutarotase isoform 2

See identical proteins and their annotated locations for NP_940874.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.

Source sequence(s)

AK129527, BC129819, CN368132

Consensus CDS

CCDS7680.1

UniProtKB/Swiss-Prot

A2VDF0

Related

ENSP00000357540.5, ENST00000368552.7

Conserved Domains (1) summary

cl00809
Location:4 → 133

RbsD_FucU; RbsD / FucU transport protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

133352773..133358019 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011539675.3 → XP_011537977.1 fucose mutarotase isoform X11

Conserved Domains (1) summary

cl00809
Location:4 → 133

RbsD_FucU; RbsD / FucU transport protein family
XM_011539673.3 → XP_011537975.1 fucose mutarotase isoform X10

Conserved Domains (1) summary

cl00809
Location:4 → 144

RbsD_FucU; RbsD / FucU transport protein family
XM_011539671.3 → XP_011537973.1 fucose mutarotase isoform X2

Conserved Domains (1) summary

cl00809
Location:4 → 158

RbsD_FucU; RbsD / FucU transport protein family
XM_011539672.3 → XP_011537974.1 fucose mutarotase isoform X3

Conserved Domains (1) summary

cl00809
Location:4 → 158

RbsD_FucU; RbsD / FucU transport protein family
XM_011539670.3 → XP_011537972.1 fucose mutarotase isoform X1

Conserved Domains (1) summary

cl00809
Location:4 → 169

RbsD_FucU; RbsD / FucU transport protein family
XM_011539674.3 → XP_011537976.1 fucose mutarotase isoform X4

Conserved Domains (1) summary

cl00809
Location:4 → 144

RbsD_FucU; RbsD / FucU transport protein family
XM_047425105.1 → XP_047281061.1 fucose mutarotase isoform X9

UniProtKB/TrEMBL

X6R6T9

Related

ENSP00000357539.1, ENST00000368551.1
XM_047425102.1 → XP_047281058.1 fucose mutarotase isoform X6
XM_047425103.1 → XP_047281059.1 fucose mutarotase isoform X7
XM_047425101.1 → XP_047281057.1 fucose mutarotase isoform X5
XM_047425104.1 → XP_047281060.1 fucose mutarotase isoform X8