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DAOA-AS1 DAOA antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 282706, updated on 10-Oct-2023

Summary

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Official Symbol
DAOA-AS1provided by HGNC
Official Full Name
DAOA antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:30243
See related
Ensembl:ENSG00000232307 MIM:607415; AllianceGenome:HGNC:30243
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G30; DAOAAS; DAOA-AS
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
13q33.2; 13q34
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (105459055..105505681, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (104679278..104725943, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (106111404..106158030, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984609 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:105760089-105760627 Neighboring gene VISTA enhancer hs1991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7979 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:105926712-105926889 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:105930992-105931492 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:105931493-105931993 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:105934754-105935689 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:105998132-105999331 Neighboring gene VISTA enhancer hs759 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:106034184-106034970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:106034971-106035756 Neighboring gene uncharacterized LOC105370344 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_31616 Neighboring gene D-amino acid oxidase activator Neighboring gene uncharacterized LOC105370345 Neighboring gene long intergenic non-protein coding RNA 343 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:106469046-106469979 Neighboring gene uncharacterized LOC124903244

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population. Zou F, et al. Schizophr Res, 2005 Mar 1. PMID 15653269
  2. Expression of the G72/G30 gene in transgenic mice induces behavioral changes. Cheng L, et al. Mol Psychiatry, 2014 Feb. PMID 23337943, Free PMC Article
  3. Behavioral changes in G72/G30 transgenic mice. Otte DM, et al. Eur Neuropsychopharmacol, 2009 May. PMID 19189879
  4. Further evidence for an association of G72/G30 with schizophrenia in Chinese. Shi J, et al. Schizophr Res, 2009 Feb. PMID 18775646, Free PMC Article
  5. Association analysis of G72/G30 polymorphisms with schizophrenia in the Korean population. Shin HD, et al. Schizophr Res, 2007 Nov. PMID 17651942

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study reports G72/G30 expression profiles and behavioral changes in a G72/G30 transgenic mouse model; the transcriptome profile changes and multiple mouse behavioral effects suggest that the G72 gene may play a role in modulating behaviors relevant to psychiatric disorders
    Title: Expression of the G72/G30 gene in transgenic mice induces behavioral changes.
  2. A homogeneous sample of 280 schizophrenia patients and 230 healthy controls of Hungarian, Caucasian descent were genotyped for polymorphisms in schizophrenia candidate genes NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A.
    Title: Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample.
  3. The transgenic mice which expression of the human G72/G30 gene locus in mice produces behavioral phenotypes that are relevant to psychiatric disorders.
    Title: Behavioral changes in G72/G30 transgenic mice.
  4. The G72/G30 complex is considered as one of the most promising candidate genes for both schizophrenia and bipolar disorder.
    Title: Further evidence for an association of G72/G30 with schizophrenia in Chinese.
  5. Some support for the individual involvement of DAO and G72(DAOA)/G30 in the etiology of bipolar disorder.
    Title: Association of DAO and G72(DAOA)/G30 genes with bipolar affective disorder.
  6. Association of polymorphism with schizophrenia not consistent with those found in other populations, and may be chance findings.
    Title: Association analysis of G72/G30 polymorphisms with schizophrenia in the Korean population.
  7. Results suggest that variability of the DAOA/G30 locus may be involved in the etiology of panic disorder.
    Title: Investigation of the DAOA/G30 locus in panic disorder.
  8. identified statistically significant differences in allele distributions of two markers rs3916965 and rs2391191, and a highly significant association between haplotype AGAC of the G72/G30 locus and schizophrenia in the Chinese population
    Title: Association of G72/G30 with schizophrenia in the Chinese population.
  9. this gene implicated in schizophrenia among Chinese population.
    Title: A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population.
  10. data suggest that a susceptibility variant for bipolar illness exists in the vicinity of the G72/G30 genes
    Title: Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • DAOA antisense RNA 1 (non-protein coding)
  • G30 transcript
  • putative protein LG30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_040247.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AY138548
    Related
    ENST00000448407.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    105459055..105505681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    104679278..104725943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172368.1: Suppressed sequence

    Description
    NM_172368.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version

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