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Trpm2 transient receptor potential cation channel, subfamily M, member 2 [ Mus musculus (house mouse) ]

Gene ID: 28240, updated on 21-Apr-2024

Summary

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Official Symbol
Trpm2provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily M, member 2provided by MGI
Primary source
MGI:MGI:1351901
See related
Ensembl:ENSMUSG00000009292 AllianceGenome:MGI:1351901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trp7; TRPC7; Trrp7; LTRPC2; 9830168K16Rik
Summary
Enables ligand-gated calcium channel activity and manganese ion transmembrane transporter activity. Involved in several processes, including calcium ion transmembrane import into cytosol; calcium-mediated signaling using intracellular calcium source; and cellular response to temperature stimulus. Acts upstream of or within manganese ion transport and response to hydroperoxide. Located in cytoplasmic vesicle membrane; lysosomal membrane; and plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human TRPM2 (transient receptor potential cation channel subfamily M member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 10.5), cerebellum adult (RPKM 4.0) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (77743556..77805746, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (77907722..77969909, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700009J07 gene Neighboring gene leucine rich repeat containing 3 Neighboring gene predicted gene, 53590 Neighboring gene predicted gene, 22394 Neighboring gene predicted gene, 22871 Neighboring gene predicted gene, 40705 Neighboring gene STARR-seq mESC enhancer starr_27210 Neighboring gene STARR-positive B cell enhancer ABC_E9033 Neighboring gene cilia and flagella associated protein 410 Neighboring gene phosphofructokinase, liver, B-type Neighboring gene STARR-positive B cell enhancer ABC_E5151

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Suppression of the NLRP3 Inflammasome through Activation of the Transient Receptor Potential Channel Melastatin 2 Promotes Osteogenesis in Tooth Extraction Sockets of Periodontitis. Li Q, et al. Am J Pathol, 2023 Feb. PMID 36410421
  2. Genetic Knockout of TRPM2 Increases Neuronal Excitability of Hippocampal Neurons by Inhibiting Kv7 Channel in Epilepsy. Ying Y, et al. Mol Neurobiol, 2022 Nov. PMID 36053438
  3. Protein kinase C-mediated phosphorylation of transient receptor potential melastatin type 2 Thr738 counteracts the effect of cytosolic Ca(2+) and elevates the temperature threshold. Kashio M, et al. J Physiol, 2022 Oct. PMID 36042566, Free PMC Article
  4. TRPM2 mediates CaMKⅡ-Beclin-1 signaling in early cortical injury after induced subarachnoid hemorrhage in mice. Tong L, et al. J Chem Neuroanat, 2022 Nov. PMID 35988814
  5. Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury. Zong P, et al. Neuron, 2022 Jun 15. PMID 35421327, Free PMC Article

See all (162) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activation of endothelial TRPM2 exacerbates blood-brain barrier degradation in ischemic stroke.
    Title: Activation of endothelial TRPM2 exacerbates blood-brain barrier degradation in ischemic stroke.
  2. Mouse transient receptor potential melastatin 2 (TRPM2) isoform 7 attenuates full-length mouse TRPM2 activity through reductions in its expression by targeting it to ER-associated degradation.
    Title: Mouse transient receptor potential melastatin 2 (TRPM2) isoform 7 attenuates full-length mouse TRPM2 activity through reductions in its expression by targeting it to ER-associated degradation.
  3. The TRPM2 ion channel regulates metabolic and thermogenic adaptations in adipose tissue of cold-exposed mice.
    Title: The TRPM2 ion channel regulates metabolic and thermogenic adaptations in adipose tissue of cold-exposed mice.
  4. Severe inflammation in C57/BL6 mice leads to prolonged cognitive impairment by initiating the IL-1beta/TRPM2 pathway.
    Title: Severe inflammation in C57/BL6 mice leads to prolonged cognitive impairment by initiating the IL-1β/TRPM2 pathway.
  5. TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasis.
    Title: TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasis.
  6. TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy.
    Title: TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy.
  7. Clusterin regulates TRPM2 to protect against myocardial injury induced by acute myocardial infarction injury.
    Title: Clusterin regulates TRPM2 to protect against myocardial injury induced by acute myocardial infarction injury.
  8. Suppression of the NLRP3 Inflammasome through Activation of the Transient Receptor Potential Channel Melastatin 2 Promotes Osteogenesis in Tooth Extraction Sockets of Periodontitis.
    Title: Suppression of the NLRP3 Inflammasome through Activation of the Transient Receptor Potential Channel Melastatin 2 Promotes Osteogenesis in Tooth Extraction Sockets of Periodontitis.
  9. TRPM2 mediates CaMK-Beclin-1 signaling in early cortical injury after induced subarachnoid hemorrhage in mice.
    Title: TRPM2 mediates CaMKⅡ-Beclin-1 signaling in early cortical injury after induced subarachnoid hemorrhage in mice.
  10. Genetic Knockout of TRPM2 Increases Neuronal Excitability of Hippocampal Neurons by Inhibiting Kv7 Channel in Epilepsy.
    Title: Genetic Knockout of TRPM2 Increases Neuronal Excitability of Hippocampal Neurons by Inhibiting Kv7 Channel in Epilepsy.
Submit: New GeneRIF Correction See all GeneRIFs (114)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables intracellularly gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables ligand-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligand-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ligand-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mono-ADP-D-ribose binding ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion transmembrane import into cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium-mediated signaling using intracellular calcium source IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to purine-containing compound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to temperature stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendritic cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within manganese ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to hydroperoxide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to purine-containing compound ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in temperature homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transient receptor potential cation channel subfamily M member 2
Names
LTrpC-2
long transient receptor potential channel 2
transient receptor potential channel 7
transient receptor protein 7
NP_001398829.1
NP_612174.2
XP_006513793.1
XP_006513794.1
XP_006513795.1
XP_006513796.1
XP_011241772.1
XP_017169449.1
XP_017169451.1
XP_036011694.1
XP_036011695.1
XP_036011696.1
XP_036011697.1
XP_036011698.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411900.1 → NP_001398829.1  transient receptor potential cation channel subfamily M member 2

    Status: VALIDATED

    Source sequence(s)
    AC153507, AC158612
    UniProtKB/Swiss-Prot
    Q5KTC0, Q91YD4
    Related
    ENSMUST00000105400.9

  2. NM_138301.2 → NP_612174.2  transient receptor potential cation channel subfamily M member 2

    See identical proteins and their annotated locations for NP_612174.2

    Status: VALIDATED

    Source sequence(s)
    AC153507, AC158612, AK036731, AK134735, AK136905, CJ108999
    Consensus CDS
    CCDS48611.1
    UniProtKB/Swiss-Prot
    Q5KTC0, Q91YD4
    Related
    ENSMUSP00000101040.3, ENSMUST00000105401.9
    Conserved Domains (4) summary
    TIGR00870
    Location:716 → 1071
    trp; transient-receptor-potential calcium channel protein
    pfam00520
    Location:800 → 976
    Ion_trans; Ion transport protein
    cl00447
    Location:1322 → 1502
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
    cl39032
    Location:140 → 363
    LSDAT_euk; SLOG in TRPM

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    77743556..77805746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513731.5 → XP_006513794.1  transient receptor potential cation channel subfamily M member 2 isoform X3

    UniProtKB/TrEMBL
    Q3UYE9
    Conserved Domains (3) summary
    TIGR00870
    Location:189 → 544
    trp; transient-receptor-potential calcium channel protein
    pfam00520
    Location:273 → 421
    Ion_trans; Ion transport protein
    cl00447
    Location:795 → 975
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  2. XM_006513732.2 → XP_006513795.1  transient receptor potential cation channel subfamily M member 2 isoform X4

    UniProtKB/TrEMBL
    Q3UYE9
    Conserved Domains (3) summary
    TIGR00870
    Location:185 → 540
    trp; transient-receptor-potential calcium channel protein
    pfam00520
    Location:269 → 417
    Ion_trans; Ion transport protein
    cl00447
    Location:791 → 971
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  3. XM_036155801.1 → XP_036011694.1  transient receptor potential cation channel subfamily M member 2 isoform X7

    Conserved Domains (2) summary
    pfam00520
    Location:7 → 123
    Ion_trans; Ion transport protein
    cl00447
    Location:469 → 649
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  4. XM_017313962.2 → XP_017169451.1  transient receptor potential cation channel subfamily M member 2 isoform X10

    Conserved Domains (1) summary
    cl00447
    Location:47 → 227
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  5. XM_036155803.1 → XP_036011696.1  transient receptor potential cation channel subfamily M member 2 isoform X9

    Conserved Domains (1) summary
    cl00447
    Location:73 → 253
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  6. XM_036155804.1 → XP_036011697.1  transient receptor potential cation channel subfamily M member 2 isoform X10

    Conserved Domains (1) summary
    cl00447
    Location:47 → 227
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  7. XM_017313960.2 → XP_017169449.1  transient receptor potential cation channel subfamily M member 2 isoform X7

    Conserved Domains (2) summary
    pfam00520
    Location:7 → 123
    Ion_trans; Ion transport protein
    cl00447
    Location:469 → 649
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  8. XM_036155805.1 → XP_036011698.1  transient receptor potential cation channel subfamily M member 2 isoform X10

    Conserved Domains (1) summary
    cl00447
    Location:47 → 227
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  9. XM_036155802.1 → XP_036011695.1  transient receptor potential cation channel subfamily M member 2 isoform X8

    Conserved Domains (1) summary
    cl00447
    Location:168 → 348
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  10. XM_006513730.3 → XP_006513793.1  transient receptor potential cation channel subfamily M member 2 isoform X2

    Conserved Domains (2) summary
    pfam00520
    Location:800 → 948
    Ion_trans; Ion transport protein
    cl39032
    Location:140 → 363
    LSDAT_euk; SLOG in TRPM

  11. XM_011243470.4 → XP_011241772.1  transient receptor potential cation channel subfamily M member 2 isoform X5

    Conserved Domains (1) summary
    cl39032
    Location:140 → 363
    LSDAT_euk; SLOG in TRPM

  12. XM_006513733.5 → XP_006513796.1  transient receptor potential cation channel subfamily M member 2 isoform X6

    Conserved Domains (1) summary
    cl39032
    Location:140 → 363
    LSDAT_euk; SLOG in TRPM

RNA

  1. XR_004936198.1 RNA Sequence

  2. XR_001779532.1 RNA Sequence

  3. XR_004936196.1 RNA Sequence

  4. XR_871714.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YD4.2 GenPept UniProtKB/Swiss-Prot:Q91YD4

Gene LinkOut

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