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SLCO4A1 solute carrier organic anion transporter family member 4A1 [ Homo sapiens (human) ]

Gene ID: 28231, updated on 3-Apr-2024

Summary

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Official Symbol
SLCO4A1provided by HGNC
Official Full Name
solute carrier organic anion transporter family member 4A1provided by HGNC
Primary source
HGNC:HGNC:10953
See related
Ensembl:ENSG00000101187 MIM:612436; AllianceGenome:HGNC:10953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POAT; OATP1; OATPE; OATP-E; OATP4A1; OATPRP1; SLC21A12
Summary
Predicted to enable sodium-independent organic anion transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in esophagus (RPKM 2.4), endometrium (RPKM 1.6) and 23 other tissues See more
Orthologs
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Genomic context

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See SLCO4A1 in Genome Data Viewer
Location:
20q13.33
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (62642503..62690740)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (64441223..64489475)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61273855..61303645)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61266847-61267348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61267349-61267848 Neighboring gene uncharacterized LOC124904949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61279493-61280066 Neighboring gene SLCO4A1 antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18213 Neighboring gene SLCO4A1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61302735-61303693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61314847-61315390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61315391-61315933 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61339152-61339665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61339666-61340178 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61340388-61340934 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61340935-61341479 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:61352726-61352918 Neighboring gene neurotensin receptor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61354746-61355285 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61366135-61366980 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:61371112-61372311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61392433-61393212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61400285-61401016 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:61407515-61407676 Neighboring gene long intergenic non-protein coding RNA 659

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Abundance of the Organic Anion-transporting Polypeptide OATP4A1 in Early-Stage Colorectal Cancer Patients: Association With Disease Relapse. Buxhofer-Ausch V, et al. Appl Immunohistochem Mol Morphol, 2019 Mar. PMID 29734253
  2. Solute carrier organic anion transporter family member 4A1 (SLCO4A1) as a prognosis marker of colorectal cancer. Ban MJ, et al. J Cancer Res Clin Oncol, 2017 Aug. PMID 28378090
  3. Identification of steroid sulfate transport processes in the human mammary gland. Pizzagalli F, et al. J Clin Endocrinol Metab, 2003 Aug. PMID 12915686
  4. Effect of DNA methylation profile on OATP3A1 and OATP4A1 transcript levels in colorectal cancer. Rawłuszko-Wieczorek AA, et al. Biomed Pharmacother, 2015 Aug. PMID 26349991
  5. Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Fujiwara K, et al. Endocrinology, 2001 May. PMID 11316767

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLCO4A1, as a novel prognostic biomarker of non-small cell lung cancer, promotes cell proliferation and migration.
    Title: SLCO4A1, as a novel prognostic biomarker of non‑small cell lung cancer, promotes cell proliferation and migration.
  2. Placental Expression of Bile Acid Transporters in Intrahepatic Cholestasis of Pregnancy.
    Title: Placental Expression of Bile Acid Transporters in Intrahepatic Cholestasis of Pregnancy.
  3. Abundance of the Organic Anion-transporting Polypeptide OATP4A1 in Early-Stage Colorectal Cancer Patients: Association With Disease Relapse.
    Title: Abundance of the Organic Anion-transporting Polypeptide OATP4A1 in Early-Stage Colorectal Cancer Patients: Association With Disease Relapse.
  4. SLCO4A1 may be a valuable marker of poor prognostic for colorectal cancer (CRC). Furthermore, SLCO4A1 plays an important role in CRC cell proliferation, migration, invasion, and carcinogenesis
    Title: Solute carrier organic anion transporter family member 4A1 (SLCO4A1) as a prognosis marker of colorectal cancer.
  5. our results revealed altered OATP3A1 and OATP4A1 mRNA levels and novel mechanisms that might be involved in their regulation in colorectal cancer
    Title: Effect of DNA methylation profile on OATP3A1 and OATP4A1 transcript levels in colorectal cancer.
  6. High OATP4A1 expression is associated with small cell lung cancer.
    Title: Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy.
  7. Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 variant 2, OATP4A1, LAT2 and CD98 were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8, MCT10, OATP3A1 variant 1 and LAT1 were similar.
    Title: The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
  9. oligomerization of Oatp1a1 with PDZK1 is critical for its proper subcellular localization and function
    Title: Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLCO4A1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables organic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables prostaglandin transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thyroid hormone transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in prostaglandin transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thyroid hormone transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
solute carrier organic anion transporter family member 4A1
Names
OATP-RP1
colon organic anion transporter
organic anion transporter polypeptide-related protein 1
organic anion transporting polypeptide E
sodium-independent organic anion transporter E
solute carrier family 21 (organic anion transporter), member 12
solute carrier family 21 member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016354.4 → NP_057438.3  solute carrier organic anion transporter family member 4A1

    See identical proteins and their annotated locations for NP_057438.3

    Status: VALIDATED

    Source sequence(s)
    AB031051, AF205072, AI660559, BC015727, BM846201
    Consensus CDS
    CCDS13501.1
    UniProtKB/Swiss-Prot
    Q96BD0, Q9H4T7, Q9H4T8, Q9H8P2, Q9NWX8, Q9UI35, Q9UIG7
    Related
    ENSP00000217159.1, ENST00000217159.6
    Conserved Domains (3) summary
    cd06174
    Location:106 → 489
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:500 → 555
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:106 → 663
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    62642503..62690740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260203.4 → XP_005260260.1  solute carrier organic anion transporter family member 4A1 isoform X3

    UniProtKB/TrEMBL
    E1P5H9, H0UI88
    Related
    ENSP00000434245.1, ENST00000497209.5
    Conserved Domains (3) summary
    cd06174
    Location:106 → 489
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:500 → 555
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:106 → 663
    OATP; Organic Anion Transporter Polypeptide (OATP) family

  2. XM_011528792.4 → XP_011527094.1  solute carrier organic anion transporter family member 4A1 isoform X1

    Conserved Domains (3) summary
    cd06174
    Location:106 → 489
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:500 → 555
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:106 → 663
    OATP; Organic Anion Transporter Polypeptide (OATP) family

  3. XM_017027827.3 → XP_016883316.1  solute carrier organic anion transporter family member 4A1 isoform X2

  4. XM_047440126.1 → XP_047296082.1  solute carrier organic anion transporter family member 4A1 isoform X4

RNA

  1. XR_001754251.3 RNA Sequence

  2. XR_007067450.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    64441223..64489475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323385.1 → XP_054179360.1  solute carrier organic anion transporter family member 4A1 isoform X3

  2. XM_054323380.1 → XP_054179355.1  solute carrier organic anion transporter family member 4A1 isoform X1

  3. XM_054323383.1 → XP_054179358.1  solute carrier organic anion transporter family member 4A1 isoform X2

  4. XM_054323387.1 → XP_054179362.1  solute carrier organic anion transporter family member 4A1 isoform X4

  5. XM_054323382.1 → XP_054179357.1  solute carrier organic anion transporter family member 4A1 isoform X5

    UniProtKB/Swiss-Prot
    Q96BD0, Q9H4T7, Q9H4T8, Q9H8P2, Q9NWX8, Q9UI35, Q9UIG7

  6. XM_054323384.1 → XP_054179359.1  solute carrier organic anion transporter family member 4A1 isoform X2

  7. XM_054323386.1 → XP_054179361.1  solute carrier organic anion transporter family member 4A1 isoform X3

  8. XM_054323381.1 → XP_054179356.1  solute carrier organic anion transporter family member 4A1 isoform X1

RNA

  1. XR_008485252.1 RNA Sequence

  2. XR_008485253.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96BD0.2 GenPept UniProtKB/Swiss-Prot:Q96BD0

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