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Cep63 centrosomal protein 63 [ Mus musculus (house mouse) ]

Gene ID: 28135, updated on 5-Mar-2024

Summary

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Official Symbol
Cep63provided by MGI
Official Full Name
centrosomal protein 63provided by MGI
Primary source
MGI:MGI:2158560
See related
Ensembl:ENSMUSG00000032534 AllianceGenome:MGI:2158560
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ET2; CD20R; D9Mgc41; D9Mgc48e; 4921501M07; AL450317.13gm1
Summary
This gene encodes a subunit of the centrosome, the main microtubule-organizing center of the cell. The encoded protein associates with another centrosomal protein, CEP152, to regulate mother-centriole-dependent centriole duplication in dividing cells. Disruption of a similar gene in human has been associated with primary microcephaly (MCPH). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Expression
Biased expression in testis adult (RPKM 38.6), CNS E11.5 (RPKM 4.6) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F1; 9 54.61 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (102461784..102503748, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (102586578..102626564, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene predicted gene 29387 Neighboring gene WD repeat domain 85 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:102528825-102529014 Neighboring gene anaphase promoting complex subunit 13 Neighboring gene VISTA enhancer mm1302 Neighboring gene STARR-seq mESC enhancer starr_25068 Neighboring gene predicted gene, 46150 Neighboring gene STARR-seq mESC enhancer starr_25069 Neighboring gene angiomotin-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Centriole biogenesis in multiciliated cells. Tang TK. Nat Cell Biol, 2013 Dec. PMID 24296417
  2. A primary microcephaly protein complex forms a ring around parental centrioles. Sir JH, et al. Nat Genet, 2011 Oct 9. PMID 21983783, Free PMC Article
  3. Massive centriole production can occur in the absence of deuterosomes in multiciliated cells. Mercey O, et al. Nat Cell Biol, 2019 Dec. PMID 31792378, Free PMC Article
  4. IL-20-Receptor Signaling Delimits IL-17 Production in Psoriatic Inflammation. Ha HL, et al. J Invest Dermatol, 2020 Jan. PMID 31252033, Free PMC Article
  5. Cep63 and cep152 cooperate to ensure centriole duplication. Brown NJ, et al. PLoS One, 2013. PMID 23936128, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study shows that IL-20-receptor signaling delimits IL-17 production in psoriatic inflammation
    Title: IL-20-Receptor Signaling Delimits IL-17 Production in Psoriatic Inflammation.
  2. In brain development, Wdr62 and Aspm localize to the proximal end of the mother centriole and interact physically, with Wdr62 required for Aspm localization, and both proteins, as well as microcephaly protein Cep63, required to localize CENPJ/CPAP/Sas-4, a final common target.
    Title: Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate.
  3. Cep63-deficient mice recapitulate Seckel syndrome pathology, microcephaly and dwarfism. Cep63 loss severely impairs meiotic recombination, leading to profound male infertility.
    Title: CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination.
  4. both mouse and human Cep63 and Cep152 cooperate to ensure efficient centriole duplication by promoting the accumulation of essential centriole duplication factors upstream of SAS-6 recruitment and procentriole formation.
    Title: Cep63 and cep152 cooperate to ensure centriole duplication.
  5. Cep63 regulates mother-centriole-dependent centriole duplication.
    Title: The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within centriole replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centriole replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within centrosome duplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of intrinsic apoptotic signaling pathway by p53 class mediator IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within meiotic telomere clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
centrosomal protein of 63 kDa
Names
centrosome protein Cep63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081122.2 → NP_001074591.1  centrosomal protein of 63 kDa isoform 1

    See identical proteins and their annotated locations for NP_001074591.1

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150
    Consensus CDS
    CCDS40743.1
    UniProtKB/TrEMBL
    F8VPJ7
    Related
    ENSMUSP00000091306.4, ENSMUST00000093791.10
    Conserved Domains (1) summary
    pfam17045
    Location:76 → 338
    CEP63; Centrosomal protein of 63 kDa

  2. NM_001301689.2 → NP_001288618.1  centrosomal protein of 63 kDa isoform 2

    See identical proteins and their annotated locations for NP_001288618.1

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150
    Consensus CDS
    CCDS90650.1
    UniProtKB/TrEMBL
    U5KVR9
    Related
    ENSMUSP00000149157.2, ENSMUST00000216281.2
    Conserved Domains (1) summary
    pfam17045
    Location:76 → 338
    CEP63; Centrosomal protein of 63 kDa

  3. NM_001407699.1 → NP_001394628.1  centrosomal protein of 63 kDa isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  4. NM_001407700.1 → NP_001394629.1  centrosomal protein of 63 kDa isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  5. NM_001407701.1 → NP_001394630.1  centrosomal protein of 63 kDa isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150
    UniProtKB/Swiss-Prot
    Q3UPP8, Q80ZM0

  6. NM_001407702.1 → NP_001394631.1  centrosomal protein of 63 kDa isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150
    UniProtKB/Swiss-Prot
    Q3UPP8, Q80ZM0

  7. NM_001407703.1 → NP_001394632.1  centrosomal protein of 63 kDa isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  8. NM_001407704.1 → NP_001394633.1  centrosomal protein of 63 kDa isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  9. NM_001407705.1 → NP_001394634.1  centrosomal protein of 63 kDa isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  10. NM_001407706.1 → NP_001394635.1  centrosomal protein of 63 kDa isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  11. NM_001407707.1 → NP_001394636.1  centrosomal protein of 63 kDa isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  12. NM_001407708.1 → NP_001394637.1  centrosomal protein of 63 kDa isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  13. NM_001407709.1 → NP_001394638.1  centrosomal protein of 63 kDa isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  14. NM_001407710.1 → NP_001394639.1  centrosomal protein of 63 kDa isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  15. NM_001407711.1 → NP_001394640.1  centrosomal protein of 63 kDa isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  16. NM_001407712.1 → NP_001394641.1  centrosomal protein of 63 kDa isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  17. NM_001407713.1 → NP_001394642.1  centrosomal protein of 63 kDa isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150
    Related
    ENSMUSP00000125621.2, ENSMUST00000162655.9

  18. NM_001407714.1 → NP_001394643.1  centrosomal protein of 63 kDa isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  19. NM_001407715.1 → NP_001394644.1  centrosomal protein of 63 kDa isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  20. NM_001407716.1 → NP_001394645.1  centrosomal protein of 63 kDa isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  21. NM_001407717.1 → NP_001394646.1  centrosomal protein of 63 kDa isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  22. NM_001407718.1 → NP_001394647.1  centrosomal protein of 63 kDa isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  23. NM_001407719.1 → NP_001394648.1  centrosomal protein of 63 kDa isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  24. NM_001407720.1 → NP_001394649.1  centrosomal protein of 63 kDa isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  25. NM_001407721.1 → NP_001394650.1  centrosomal protein of 63 kDa isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  26. NM_001407722.1 → NP_001394651.1  centrosomal protein of 63 kDa isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  27. NM_001407723.1 → NP_001394652.1  centrosomal protein of 63 kDa isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

RNA

  1. NR_176403.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  2. NR_176404.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  3. NR_176405.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  4. NR_176406.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  5. NR_176407.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  6. NR_176408.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  7. NR_176409.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  8. NR_176410.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

  9. NR_176411.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL450317, CT573150

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    102461784..102503748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511747.5 → XP_006511810.1  centrosomal protein of 63 kDa isoform X15

    Conserved Domains (2) summary
    TIGR02169
    Location:145 → 498
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam17045
    Location:18 → 239
    CEP63; Centrosomal protein of 63 kDa

  2. XM_036155044.1 → XP_036010937.1  centrosomal protein of 63 kDa isoform X12

    Conserved Domains (2) summary
    COG1196
    Location:216 → 522
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17045
    Location:76 → 297
    CEP63; Centrosomal protein of 63 kDa

  3. XM_011242886.2 → XP_011241188.1  centrosomal protein of 63 kDa isoform X11

    Conserved Domains (2) summary
    TIGR02169
    Location:224 → 577
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam17045
    Location:97 → 318
    CEP63; Centrosomal protein of 63 kDa

  4. XM_017313406.1 → XP_017168895.1  centrosomal protein of 63 kDa isoform X1

    Conserved Domains (2) summary
    pfam15921
    Location:102 → 667
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17045
    Location:97 → 359
    CEP63; Centrosomal protein of 63 kDa

  5. XM_011242890.3 → XP_011241192.1  centrosomal protein of 63 kDa isoform X16

    Conserved Domains (2) summary
    COG1196
    Location:278 → 563
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17045
    Location:97 → 359
    CEP63; Centrosomal protein of 63 kDa

  6. XM_030244411.2 → XP_030100271.1  centrosomal protein of 63 kDa isoform X20

    Conserved Domains (2) summary
    TIGR02168
    Location:139 → 485
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17045
    Location:81 → 302
    CEP63; Centrosomal protein of 63 kDa

  7. XM_017313416.3 → XP_017168905.1  centrosomal protein of 63 kDa isoform X23

    Conserved Domains (1) summary
    pfam05483
    Location:51 → 247
    SCP-1; Synaptonemal complex protein 1 (SCP-1)

  8. XM_011242885.3 → XP_011241187.1  centrosomal protein of 63 kDa isoform X9

    Conserved Domains (2) summary
    pfam15921
    Location:53 → 635
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17045
    Location:70 → 332
    CEP63; Centrosomal protein of 63 kDa

  9. XM_017313407.2 → XP_017168896.1  centrosomal protein of 63 kDa isoform X4

    Conserved Domains (2) summary
    pfam15921
    Location:91 → 656
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17045
    Location:86 → 348
    CEP63; Centrosomal protein of 63 kDa

  10. XM_017313408.2 → XP_017168897.1  centrosomal protein of 63 kDa isoform X6

    Conserved Domains (2) summary
    pfam15921
    Location:46 → 646
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17045
    Location:81 → 343
    CEP63; Centrosomal protein of 63 kDa

  11. XM_017313411.3 → XP_017168900.1  centrosomal protein of 63 kDa isoform X17

    Conserved Domains (2) summary
    pfam15921
    Location:46 → 577
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17045
    Location:81 → 343
    CEP63; Centrosomal protein of 63 kDa

  12. XM_006511744.4 → XP_006511807.1  centrosomal protein of 63 kDa isoform X13

    See identical proteins and their annotated locations for XP_006511807.1

    Conserved Domains (2) summary
    TIGR02169
    Location:202 → 555
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam17045
    Location:34 → 296
    CEP63; Centrosomal protein of 63 kDa

  13. XM_011242882.3 → XP_011241184.1  centrosomal protein of 63 kDa isoform X3

    Conserved Domains (2) summary
    pfam15921
    Location:97 → 662
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17045
    Location:92 → 354
    CEP63; Centrosomal protein of 63 kDa

  14. XM_011242883.3 → XP_011241185.1  centrosomal protein of 63 kDa isoform X5

    Conserved Domains (2) summary
    pfam15921
    Location:90 → 655
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17045
    Location:85 → 347
    CEP63; Centrosomal protein of 63 kDa

  15. XM_006511739.3 → XP_006511802.1  centrosomal protein of 63 kDa isoform X2

    Conserved Domains (2) summary
    pfam15921
    Location:101 → 666
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17045
    Location:96 → 358
    CEP63; Centrosomal protein of 63 kDa

  16. XM_011242884.3 → XP_011241186.1  centrosomal protein of 63 kDa isoform X7

    Conserved Domains (2) summary
    pfam15921
    Location:86 → 651
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17045
    Location:81 → 343
    CEP63; Centrosomal protein of 63 kDa

RNA

  1. XR_004935447.1 RNA Sequence

  2. XR_004935448.1 RNA Sequence

  3. XR_001778924.1 RNA Sequence

  4. XR_001778922.1 RNA Sequence

  5. XR_001778923.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UPP8.2 GenPept UniProtKB/Swiss-Prot:Q3UPP8

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