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Med10 mediator complex subunit 10 [ Mus musculus (house mouse) ]

Gene ID: 28077, updated on 11-Apr-2024

Summary

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Official Symbol
Med10provided by MGI
Official Full Name
mediator complex subunit 10provided by MGI
Primary source
MGI:MGI:106331
See related
Ensembl:ENSMUSG00000021598 AllianceGenome:MGI:106331
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D13Wsu50e
Summary
Predicted to enable transcription coregulator activity. Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II and stem cell population maintenance. Part of mediator complex. Is expressed in embryo and extraembryonic component. Orthologous to human MED10 (mediator complex subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 24.5), ovary adult (RPKM 9.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 C1; 13 35.55 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (69950467..69964221)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (69802348..69816102)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930547H16 gene Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene RIKEN cDNA 4933416O17 gene Neighboring gene STARR-seq mESC enhancer starr_34946 Neighboring gene predicted gene, 36019

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Malik S, et al. Mol Cell Biol, 2004 Sep. PMID 15340084, Free PMC Article
  2. Novel critical role of a human Mediator complex for basal RNA polymerase II transcription. Mittler G, et al. EMBO Rep, 2001 Sep. PMID 11559591, Free PMC Article
  3. Mediator and cohesin connect gene expression and chromatin architecture. Kagey MH, et al. Nature, 2010 Sep 23. PMID 20720539, Free PMC Article
  4. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
  5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 10
Names
mediator of RNA polymerase II transcription, subunit 10 homolog (NUT2, S. cerevisiae)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378925.1 → NP_001365854.1  mediator of RNA polymerase II transcription subunit 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122371
    Conserved Domains (1) summary
    pfam09748
    Location:38 → 155
    Med10; Transcription factor subunit Med10 of Mediator complex

  2. NM_138596.2 → NP_613062.1  mediator of RNA polymerase II transcription subunit 10 isoform 1

    See identical proteins and their annotated locations for NP_613062.1

    Status: PROVISIONAL

    Source sequence(s)
    AK013992
    Consensus CDS
    CCDS26625.1
    UniProtKB/Swiss-Prot
    Q3U0W8, Q80VV0, Q9CXU0
    Related
    ENSMUSP00000022089.9, ENSMUST00000022089.10
    Conserved Domains (1) summary
    pfam09748
    Location:9 → 126
    Med10; Transcription factor subunit Med10 of Mediator complex

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    69950467..69964221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517275.3 → XP_006517338.1  mediator of RNA polymerase II transcription subunit 10 isoform X1

    UniProtKB/TrEMBL
    A0A1Y7VMY2
    Related
    ENSMUSP00000152144.2, ENSMUST00000221893.2
    Conserved Domains (1) summary
    pfam09748
    Location:40 → 132
    Med10; Transcription factor subunit Med10 of Mediator complex
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXU0.1 GenPept UniProtKB/Swiss-Prot:Q9CXU0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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