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Polr1f RNA polymerase I subunit F [ Mus musculus (house mouse) ]

Gene ID: 28071, updated on 11-Apr-2024

Summary

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Official Symbol
Polr1fprovided by MGI
Official Full Name
RNA polymerase I subunit Fprovided by MGI
Primary source
MGI:MGI:106292
See related
Ensembl:ENSMUSG00000020561 AllianceGenome:MGI:106292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Twistnb; D16Wsu83e; 2410173G11; 2810024J17Rik
Summary
Predicted to enable DNA-directed 5'-3' RNA polymerase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex. Is expressed in extraembryonic component. Orthologous to human POLR1F (RNA polymerase I subunit F). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 9.0), adrenal adult (RPKM 6.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 A3; 12 14.38 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (33479593..33491434)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (33429624..33439380)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ataxin 7-like 1 Neighboring gene ataxin 7-like 1, opposite strand 2 Neighboring gene STARR-seq mESC enhancer starr_31895 Neighboring gene EF-hand calcium binding domain 10 Neighboring gene STARR-seq mESC enhancer starr_31896 Neighboring gene STARR-positive B cell enhancer ABC_E2381 Neighboring gene predicted gene, 23529 Neighboring gene ribosomal protein SA pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterisation of the gene TWIST NEIGHBOR (TWISTNB) located in the microdeletion syndrome 7p21 region. Kosan C, et al. Cytogenet Genome Res, 2002. PMID 12438708
  2. Partial transcriptome of the developing pituitary gland. Douglas KR, et al. Genomics, 2000 Dec 15. PMID 11161784
  3. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
  4. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
  5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated transcription initiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transcription elongation by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase I complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase I subunit RPA43
Names
DNA-directed RNA polymerase I subunit F
twist basic helix-loop-helix transcription factor 1 neighbor
twist neighbor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172253.2 → NP_758457.1  DNA-directed RNA polymerase I subunit RPA43

    See identical proteins and their annotated locations for NP_758457.1

    Status: VALIDATED

    Source sequence(s)
    AK010829, AK016638, AK160682
    Consensus CDS
    CCDS25877.1
    UniProtKB/Swiss-Prot
    Q3U6L1, Q78WZ7, Q8CEP7, Q9CS60
    UniProtKB/TrEMBL
    B2RT77
    Related
    ENSMUSP00000020877.8, ENSMUST00000020877.9
    Conserved Domains (1) summary
    cd04328
    Location:43 → 126
    RNAP_I_Rpa43_N; RNAP_I_Rpa43_N: Rpa43, N-terminal ribonucleoprotein (RNP) domain. Rpa43 is a subunit of eukaryotic RNA polymerase (RNAP) I that is homologous to Rpb7 of eukaryotic RNAP II, Rpc25 of eukaryotic RNP III, and RpoE of archaeal RNAP. Rpa43 has two domains, an ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    33479593..33491434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157465.1 → XP_036013358.1  DNA-directed RNA polymerase I subunit RPA43 isoform X1

    Conserved Domains (1) summary
    pfam17875
    Location:100 → 125
    RPA43_OB; RPA43 OB domain in RNA Pol I
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q78WZ7.1 GenPept UniProtKB/Swiss-Prot:Q78WZ7

Gene LinkOut

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