B3gat2 beta-1,3-glucuronyltransferase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: B3gat2provided by MGI
Official Full Name: beta-1,3-glucuronyltransferase 2provided by MGI
Primary source: MGI:MGI:2389490
See related: Ensembl:ENSMUSG00000026156 AllianceGenome:MGI:2389490
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Glcats; GlcAT-S
Summary: Predicted to enable galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity. Predicted to be involved in carbohydrate biosynthetic process and chondroitin sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Barrett's esophagus and schizophrenia. Orthologous to human B3GAT2 (beta-1,3-glucuronyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 17.5), testis adult (RPKM 14.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 A5; 1 9.75 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (23801007..23886946)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (23761926..23847865)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

moderate expression of GlcAT-S were seen in neuronal cells of several nuclei of limbic-related regions
Title: Distributions of glucuronyltransferases, GlcAT-P and GlcAT-S, and their target substrate, the HNK-1 carbohydrate epitope in the adult mouse brain with or without a targeted deletion of the GlcAT-P gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI462175 (e-PCR)
- UniSTS:158779

B3gat2 (e-PCR), detects polymorphism
- UniSTS:507999

NoName (e-PCR)
- UniSTS:546678

B3gat2 (e-PCR), detects polymorphism
- UniSTS:546678

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondroitin sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2

Names: UDP-glucuronosyltransferase-S; glcAT-D; glucuronosyltransferase S

NP_742122.2

EC 2.4.1.135

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172124.2 → NP_742122.2 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 precursor

See identical proteins and their annotated locations for NP_742122.2

Status: VALIDATED

Source sequence(s)

AK052640, BC058082

Consensus CDS

CCDS14850.1

UniProtKB/Swiss-Prot

P59270

UniProtKB/TrEMBL

Q5DTT7

Related

ENSMUSP00000066582.6, ENSMUST00000063663.6

Conserved Domains (1) summary

cd00218
Location:81 → 306

GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis