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GOLGA4 golgin A4 [ Homo sapiens (human) ]

Gene ID: 2803, updated on 14-Apr-2024

Summary

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Official Symbol
GOLGA4provided by HGNC
Official Full Name
golgin A4provided by HGNC
Primary source
HGNC:HGNC:4427
See related
Ensembl:ENSG00000144674 MIM:602509; AllianceGenome:HGNC:4427
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCP2; GOLG; p230; CRPF46; MU-RMS-40.18
Summary
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
Expression
Ubiquitous expression in thyroid (RPKM 27.2), testis (RPKM 25.9) and 25 other tissues See more
Orthologs
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Genomic context

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See GOLGA4 in Genome Data Viewer
Location:
3p22.2
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (37243271..37366879)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (37244671..37368411)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (37284762..37408370)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377642 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124909483 Neighboring gene CRISPRi-validated cis-regulatory element chr3.1280 Neighboring gene H3K27ac hESC enhancers GRCh37_chr3:37283961-37284580 and GRCh37_chr3:37284581-37285200 Neighboring gene GOLGA4 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:37339657-37340856 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:37343371-37344032 Neighboring gene transcription elongation factor A1 pseudogene 2 Neighboring gene MPRA-validated peak4611 silencer Neighboring gene RNA, 5S ribosomal pseudogene 129 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:37485219-37485403 Neighboring gene APRG1 tumor suppressor candidate Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14199 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37516063-37516575 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37516576-37517087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37539704-37540204 Neighboring gene integrin subunit alpha 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37579429-37579930 Neighboring gene RNA, U7 small nuclear 73 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Golgin A4 in CSF and granulovacuolar degenerations of patients with Alzheimer disease. Kork F, et al. Neurology, 2018 Nov 6. PMID 30305446
  2. Trans-Golgi protein p230/golgin-245 is involved in phagophore formation. Sohda M, et al. Biochem Biophys Res Commun, 2015 Jan 2. PMID 25436429
  3. Identification of a novel centrosomal protein CrpF46 involved in cell cycle progression and mitosis. Wei Y, et al. Exp Cell Res, 2008 May 1. PMID 18394601
  4. tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre. Yoshino A, et al. J Cell Sci, 2005 May 15. PMID 15870108
  5. p230 is associated with vesicles budding from the trans-Golgi network. Gleeson PA, et al. J Cell Sci, 1996 Dec. PMID 9013329

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of a novel GOLGA4-JAK2 fusion gene in B-cell acute lymphoblastic leukaemia.
    Title: Identification of a novel GOLGA4-JAK2 fusion gene in B-cell acute lymphoblastic leukaemia.
  2. CrpF46 regulates cell migration by centrosomal reorientation and altering the function of the actomyosin network by controlling specific phosphorylation of myosin.
    Title: The actomyosin network is influenced by NMHC IIA and regulated by Crp(F46), which is involved in controlling cell migration.
  3. This study provides Class III evidence that elevated cerebrospinal fluid golgin A4 levels identify patients with Alzheimer disease.
    Title: Golgin A4 in CSF and granulovacuolar degenerations of patients with Alzheimer disease.
  4. p230 is an important molecule in phagophore formation, although it remains unclear whether p230 has any role in late steps of autophagy
    Title: Trans-Golgi protein p230/golgin-245 is involved in phagophore formation.
  5. CD99 also binds p230/golgin-245, a coiled-coil protein that recycles between the cytosol and buds/vesicles of the TGN and which plays a fundamental role in trafficking transport vesicles.
    Title: Regulation of HLA class I surface expression requires CD99 and p230/golgin-245 interaction.
  6. The protein CrpF46 has an apparent molecular mass of ~60 kDa, is highly homologous to a 527 amino acid sequence of the C-terminal portion of the protein Golgin-245, and appears to be a splice variant of Golgin-245.
    Title: Identification of a novel centrosomal protein CrpF46 involved in cell cycle progression and mitosis.
  7. golgin-245 is a key regulator of TNF secretion; LPS activation of macrophages results in increased Golgi carriers for export, up-regulating the transport pathway for TNF export.
    Title: A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo.
  8. The ability of the four mammalian GRIP domain proteins, p230, golgin-97, GCC88, and GCC185 to interact is reported.
    Title: The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers.
  9. tGolgin-1 functions in Golgi positioning indirectly, probably by regulating retrograde movement of cargo required for recruitment or activation of dynein-dynactin complexes on newly formed Golgi elements.
    Title: tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre.
  10. crystal structure of Arl1-GTP in complex with the GRIP domain of golgin-245 shows that Arl1-GTP interacts with the GRIP domain predominantly in a hydrophobic manner, with the switch II region conferring the main recognition surface
    Title: Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120/MBL complex co-localizes with the ER marker Erp57 and the Golgi marker p230 at subcellular perinuclear compartments in neuronal cells PubMed
Nef nef Genome-wide shRNA screening identifies GOLGA4, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed
Vpu vpu HIV-1 Vpu co-localizes with the TGN marker p230 (Golgin) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Golgi vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of axon extension IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in trans-Golgi network TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
golgin subfamily A member 4
Names
256 kDa golgin
72.1 protein
centrosome-related protein F46
golgi autoantigen, golgin subfamily a, 4
golgin-240
golgin-245
protein 72.1
trans-Golgi p230

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047053.1 RefSeqGene

    Range
    5081..128689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001172713.3 → NP_001166184.1  golgin subfamily A member 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC097359
    Consensus CDS
    CCDS54564.1
    UniProtKB/Swiss-Prot
    Q13439
    UniProtKB/TrEMBL
    Q49A56
    Related
    ENSP00000349305.4, ENST00000356847.8
    Conserved Domains (2) summary
    smart00755
    Location:2187 → 2230
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:1468 → 2109
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. NM_001410721.2 → NP_001397650.1  golgin subfamily A member 4 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC097359
    Consensus CDS
    CCDS93242.1
    UniProtKB/TrEMBL
    H0Y6I0
    Related
    ENSP00000405842.2, ENST00000437131.2

  3. NM_001429190.1 → NP_001416119.1  golgin subfamily A member 4 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC097359

  4. NM_001429191.1 → NP_001416120.1  golgin subfamily A member 4 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC097359

  5. NM_001429193.1 → NP_001416122.1  golgin subfamily A member 4 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC097359

  6. NM_001429196.1 → NP_001416125.1  golgin subfamily A member 4 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC097359

  7. NM_001429198.1 → NP_001416127.1  golgin subfamily A member 4 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC097359

  8. NM_001429201.1 → NP_001416130.1  golgin subfamily A member 4 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC097359

  9. NM_001429202.1 → NP_001416131.1  golgin subfamily A member 4 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC097359

  10. NM_002078.5 → NP_002069.2  golgin subfamily A member 4 isoform 2

    See identical proteins and their annotated locations for NP_002069.2

    Status: REVIEWED

    Source sequence(s)
    AW881112, BC045543, U41740
    Consensus CDS
    CCDS2666.1
    UniProtKB/Swiss-Prot
    F8W8Q7, Q13270, Q13439, Q13654, Q14436, Q59EW8
    Related
    ENSP00000354486.2, ENST00000361924.7
    Conserved Domains (4) summary
    PTZ00121
    Location:315 → 997
    PTZ00121; MAEBL; Provisional
    smart00755
    Location:2172 → 2215
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:1446 → 2141
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:136 → 452
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    37243271..37366879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447981.1 → XP_047303937.1  golgin subfamily A member 4 isoform X7

  2. XM_047447980.1 → XP_047303936.1  golgin subfamily A member 4 isoform X7

  3. XM_024453457.2 → XP_024309225.1  golgin subfamily A member 4 isoform X17

    Conserved Domains (3) summary
    smart00755
    Location:2053 → 2096
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    cl25732
    Location:1327 → 2022
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:196 → 878
    Neuromodulin_N; Gap junction protein N-terminal region

  4. XM_005265069.4 → XP_005265126.1  golgin subfamily A member 4 isoform X1

    UniProtKB/TrEMBL
    C9J0Y3
    Related
    ENSP00000392907.2, ENST00000431105.2
    Conserved Domains (2) summary
    smart00755
    Location:2227 → 2270
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:1501 → 2196
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. XM_005265070.4 → XP_005265127.1  golgin subfamily A member 4 isoform X2

    UniProtKB/TrEMBL
    A0A9L9PX25
    Related
    ENSP00000516454.1, ENST00000706569.1
    Conserved Domains (2) summary
    smart00755
    Location:2227 → 2270
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:1501 → 2196
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. XM_005265071.4 → XP_005265128.1  golgin subfamily A member 4 isoform X3

    Conserved Domains (2) summary
    smart00755
    Location:2220 → 2263
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:1501 → 2142
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  7. XM_017006184.2 → XP_016861673.1  golgin subfamily A member 4 isoform X4

  8. XM_005265072.4 → XP_005265129.1  golgin subfamily A member 4 isoform X5

    Conserved Domains (2) summary
    smart00755
    Location:2211 → 2254
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:1485 → 2180
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  9. XM_006713110.3 → XP_006713173.1  golgin subfamily A member 4 isoform X8

    Conserved Domains (2) summary
    smart00755
    Location:2192 → 2235
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:1466 → 2161
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  10. XM_005265073.2 → XP_005265130.1  golgin subfamily A member 4 isoform X6

    UniProtKB/TrEMBL
    A0A8V8TQI6
    Related
    ENSP00000514745.1, ENST00000699995.1
    Conserved Domains (2) summary
    smart00755
    Location:2194 → 2237
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:1468 → 2163
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  11. XM_005265074.2 → XP_005265131.1  golgin subfamily A member 4 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPI8
    Related
    ENSP00000514746.1, ENST00000699996.1
    Conserved Domains (2) summary
    smart00755
    Location:2187 → 2230
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:1468 → 2109
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  12. XM_017006187.2 → XP_016861676.1  golgin subfamily A member 4 isoform X10

  13. XM_047447983.1 → XP_047303939.1  golgin subfamily A member 4 isoform X11

  14. XM_047447985.1 → XP_047303941.1  golgin subfamily A member 4 isoform X13

  15. XM_047447986.1 → XP_047303942.1  golgin subfamily A member 4 isoform X14

  16. XM_047447984.1 → XP_047303940.1  golgin subfamily A member 4 isoform X12

  17. XM_005265075.2 → XP_005265132.1  golgin subfamily A member 4 isoform X15

    Conserved Domains (2) summary
    smart00755
    Location:2156 → 2199
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:1430 → 2125
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  18. XM_017006188.2 → XP_016861677.1  golgin subfamily A member 4 isoform X16

  19. XM_011533598.4 → XP_011531900.1  golgin subfamily A member 4 isoform X18

    Conserved Domains (2) summary
    smart00755
    Location:1735 → 1778
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:1009 → 1704
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    37244671..37368411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346209.1 → XP_054202184.1  golgin subfamily A member 4 isoform X7

  2. XM_054346208.1 → XP_054202183.1  golgin subfamily A member 4 isoform X7

  3. XM_054346219.1 → XP_054202194.1  golgin subfamily A member 4 isoform X17

  4. XM_054346202.1 → XP_054202177.1  golgin subfamily A member 4 isoform X1

    UniProtKB/TrEMBL
    C9J0Y3

  5. XM_054346203.1 → XP_054202178.1  golgin subfamily A member 4 isoform X2

    UniProtKB/TrEMBL
    A0A9L9PX25

  6. XM_054346204.1 → XP_054202179.1  golgin subfamily A member 4 isoform X3

  7. XM_054346205.1 → XP_054202180.1  golgin subfamily A member 4 isoform X4

  8. XM_054346206.1 → XP_054202181.1  golgin subfamily A member 4 isoform X5

  9. XM_054346210.1 → XP_054202185.1  golgin subfamily A member 4 isoform X8

  10. XM_054346207.1 → XP_054202182.1  golgin subfamily A member 4 isoform X6

    UniProtKB/TrEMBL
    A0A8V8TQI6

  11. XM_054346211.1 → XP_054202186.1  golgin subfamily A member 4 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPI8

  12. XM_054346212.1 → XP_054202187.1  golgin subfamily A member 4 isoform X10

  13. XM_054346213.1 → XP_054202188.1  golgin subfamily A member 4 isoform X11

  14. XM_054346215.1 → XP_054202190.1  golgin subfamily A member 4 isoform X13

  15. XM_054346216.1 → XP_054202191.1  golgin subfamily A member 4 isoform X14

  16. XM_054346214.1 → XP_054202189.1  golgin subfamily A member 4 isoform X12

  17. XM_054346217.1 → XP_054202192.1  golgin subfamily A member 4 isoform X15

  18. XM_054346218.1 → XP_054202193.1  golgin subfamily A member 4 isoform X16

  19. XM_054346220.1 → XP_054202195.1  golgin subfamily A member 4 isoform X18

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13439.1 GenPept UniProtKB/Swiss-Prot:Q13439

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