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Polr2m polymerase (RNA) II (DNA directed) polypeptide M [ Mus musculus (house mouse) ]

Gene ID: 28015, updated on 5-Mar-2024

Summary

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Official Symbol
Polr2mprovided by MGI
Official Full Name
polymerase (RNA) II (DNA directed) polypeptide Mprovided by MGI
Primary source
MGI:MGI:107282
See related
Ensembl:ENSMUSG00000032199 AllianceGenome:MGI:107282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Grinl1a; D9Wsu138e; mKIAA4185
Summary
Predicted to enable DNA-directed 5'-3' RNA polymerase activity. Involved in maintenance of ER location. Located in neuronal cell body. Is expressed in brain; extraembryonic component; and genitourinary system. Orthologous to several human genes including GCOM1 (GCOM1, MYZAP-POLR2M combined locus). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 79.8), limb E14.5 (RPKM 68.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 D; 9 39.85 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (71385719..71393265, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (71478437..71485983, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24569 Neighboring gene aldehyde dehydrogenase family 1, subfamily A2 Neighboring gene STARR-seq mESC enhancer starr_24571 Neighboring gene predicted gene, 32769 Neighboring gene STARR-seq mESC enhancer starr_24572 Neighboring gene STARR-seq mESC enhancer starr_24574 Neighboring gene myocardial zonula adherens protein Neighboring gene STARR-seq mESC enhancer starr_24575 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:71418063-71418246 Neighboring gene MAD1 mitotic arrest deficient 1-like 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The mouse orthologue of the human ionotropic glutamate receptor-like gene (GRINL1A) maps(1) to mouse chromosome 9. Wydner KS, et al. Cytogenet Cell Genet, 2001. PMID 12063408
  2. The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis. Stavast CJ, et al. Leukemia, 2022 Mar. PMID 34741119, Free PMC Article
  3. Transcriptional down-regulation of metabolic genes by Gdown1 ablation induces quiescent cell re-entry into the cell cycle. Jishage M, et al. Genes Dev, 2020 Jun 1. PMID 32381628, Free PMC Article
  4. Specific assembly with the NMDA receptor 3B subunit controls surface expression and calcium permeability of NMDA receptors. Matsuda K, et al. J Neurosci, 2003 Nov 5. PMID 14602821, Free PMC Article
  5. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis.
    Title: The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis.
  2. Transcriptional down-regulation of metabolic genes by Gdown1 ablation induces quiescent cell re-entry into the cell cycle.
    Title: Transcriptional down-regulation of metabolic genes by Gdown1 ablation induces quiescent cell re-entry into the cell cycle.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4185

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables transcription elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of ER location IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of ER location IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in I band IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II, core complex ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase II, holoenzyme IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription preinitiation complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase II subunit GRINL1A
Names
DNA-directed RNA polymerase II subunit M
glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
glutamate receptor-like protein 1A
protein GRINL1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164793.1 → NP_001158265.1  DNA-directed RNA polymerase II subunit GRINL1A isoform 2

    See identical proteins and their annotated locations for NP_001158265.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK002571, BE993895
    Consensus CDS
    CCDS52853.1
    UniProtKB/Swiss-Prot
    Q6P6I6
    Related
    ENSMUSP00000132335.2, ENSMUST00000163972.2
    Conserved Domains (1) summary
    pfam15328
    Location:1 → 135
    GCOM2; Putative GRINL1B complex locus protein 2

  2. NM_178602.3 → NP_848717.1  DNA-directed RNA polymerase II subunit GRINL1A isoform 1

    See identical proteins and their annotated locations for NP_848717.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK052037, BE993895, BQ443340
    Consensus CDS
    CCDS23326.1
    UniProtKB/Swiss-Prot
    Q6P6I6, Q8CG13, Q9CXJ7, Q9DCQ9
    Related
    ENSMUSP00000034720.6, ENSMUST00000034720.12
    Conserved Domains (1) summary
    pfam15328
    Location:37 → 239
    GCOM2; Putative GRINL1B complex locus protein 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    71385719..71393265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P6I6.2 GenPept UniProtKB/Swiss-Prot:Q6P6I6

Gene LinkOut

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