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Washc2 WASH complex subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 28006, updated on 16-Apr-2024

Summary

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Official Symbol
Washc2provided by MGI
Official Full Name
WASH complex subunit 2provided by MGI
Primary source
MGI:MGI:106463
See related
Ensembl:ENSMUSG00000024104 AllianceGenome:MGI:106463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam21; D6Wsu116e; A130095H06; C530005J20Rik
Summary
Predicted to enable phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and retromer complex binding activity. Predicted to be involved in protein localization to endosome and retrograde transport, endosome to Golgi. Predicted to act upstream of or within protein transport. Part of WASH complex. Is expressed in several structures, including extraembryonic component; liver; and neural retina. Orthologous to human WASHC2A (WASH complex subunit 2A) and WASHC2C (WASH complex subunit 2C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 42.3), CNS E11.5 (RPKM 17.3) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 E3; 6 53.76 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (116184988..116239632)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (116208019..116262672)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled coil domains 1 Neighboring gene RIKEN cDNA 9530062K07 gene Neighboring gene H2A histone family, member Z pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2799 Neighboring gene predicted gene, 52873 Neighboring gene zinc finger, AN1-type domain 4 Neighboring gene STARR-seq mESC enhancer starr_17102 Neighboring gene membrane associated ring-CH-type finger 8 Neighboring gene predicted gene, 23527

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans. Kulkarni R, et al. Life Sci Alliance, 2023 Apr. PMID 36717248, Free PMC Article
  2. A FAM21-containing WASH complex regulates retromer-dependent sorting. Gomez TS, et al. Dev Cell, 2009 Nov. PMID 19922874, Free PMC Article
  3. Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour. Tyrrell BJ, et al. Pigment Cell Melanoma Res, 2016 Sep. PMID 27390154, Free PMC Article
  4. Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous Kras(G12D). Huang J, et al. Sci Rep, 2019 Nov 20. PMID 31748650, Free PMC Article
  5. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. Derivery E, et al. Dev Cell, 2009 Nov. PMID 19922875

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans.
    Title: FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-5-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables retromer complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables retromer complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endosomal transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein localization to endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Arp2/3 complex-mediated actin nucleation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of WASH complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of WASH complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of WASH complex ISO
Inferred from Sequence Orthology
more info
  
part_of WASH complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WASH complex subunit 2
Names
WASH complex subunit 2`
WASH complex subunit FAM21
family with sequence similarity 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026585.3 → NP_080861.2  WASH complex subunit 2

    See identical proteins and their annotated locations for NP_080861.2

    Status: VALIDATED

    Source sequence(s)
    AK038318, AK145716, BY768668, W45964
    Consensus CDS
    CCDS20450.1
    UniProtKB/Swiss-Prot
    Q3TQ99, Q6PGL7, Q80TW8, Q80UQ4, Q8CAP0
    Related
    ENSMUSP00000038983.9, ENSMUST00000036759.11
    Conserved Domains (1) summary
    pfam15255
    Location:944 → 1071
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    116184988..116239632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506214.4 → XP_006506277.1  WASH complex subunit 2 isoform X1

    Conserved Domains (1) summary
    pfam15255
    Location:920 → 1054
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

  2. XM_030255438.2 → XP_030111298.1  WASH complex subunit 2 isoform X2

    Conserved Domains (1) summary
    pfam15255
    Location:891 → 983
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

  3. XM_036166202.1 → XP_036022095.1  WASH complex subunit 2 isoform X3

    UniProtKB/TrEMBL
    A0A0N4SV74
    Related
    ENSMUSP00000144982.2, ENSMUST00000204476.3

RNA

  1. XR_003956205.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PGL7.1 GenPept UniProtKB/Swiss-Prot:Q6PGL7

Gene LinkOut

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