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Eif3b eukaryotic translation initiation factor 3, subunit B [ Mus musculus (house mouse) ]

Gene ID: 27979, updated on 5-Mar-2024

Summary

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Official Symbol
Eif3bprovided by MGI
Official Full Name
eukaryotic translation initiation factor 3, subunit Bprovided by MGI
Primary source
MGI:MGI:106478
See related
Ensembl:ENSMUSG00000056076 AllianceGenome:MGI:106478
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PRT1; Eif3s9; D5Wsu45e; EIF3-ETA; EIF3-P110; EIF3-P116
Summary
Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is active in synapse. Is expressed in several structures, including central nervous system; extraembryonic component; and sensory organ. Orthologous to human EIF3B (eukaryotic translation initiation factor 3 subunit B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 106.5), ovary adult (RPKM 52.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 78.97 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (140405060..140429113)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (140419305..140443358)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene sorting nexin 8 Neighboring gene STARR-positive B cell enhancer ABC_E9018 Neighboring gene STARR-positive B cell enhancer ABC_E9267 Neighboring gene predicted gene, 30550 Neighboring gene STARR-positive B cell enhancer ABC_E1696 Neighboring gene microRNA 7038 Neighboring gene STARR-seq mESC enhancer starr_14711 Neighboring gene kinesin family member 19B Neighboring gene STARR-positive B cell enhancer ABC_E2181 Neighboring gene STARR-positive B cell enhancer ABC_E11306 Neighboring gene predicted gene, 38728 Neighboring gene STARR-positive B cell enhancer ABC_E10361 Neighboring gene carbohydrate sulfotransferase 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Combination of piR-823 and Eukaryotic Initiation Factor 3 B (EIF3B) Activates Hepatic Stellate Cells via Upregulating TGF-β1 in Liver Fibrogenesis. Tang X, et al. Med Sci Monit, 2018 Dec 17. PMID 30556540, Free PMC Article
  2. Embryonic lethality of mutant mice deficient in the p116 gene. Koyanagi-Katsuta R, et al. J Biochem, 2002 Jun. PMID 12038979
  3. Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner. Nedelko T, et al. BMC Genomics, 2012 Aug 20. PMID 22905720, Free PMC Article
  4. A mouse gene of the paired-related homeobox class expressed in the caudal somite compartment and in the developing vertebral column, kidney and nervous system. Neidhardt LM, et al. Dev Genes Evol, 1997 Nov. PMID 27747430
  5. mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin. Harris TE, et al. EMBO J, 2006 Apr 19. PMID 16541103, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data illustrate a novel mechanism of piR-823 in HSC activities. The combination of piR-823 and EIF3B increased TGF-beta1 expression, which activates HSCs in liver fibrosis.
    Title: The Combination of piR-823 and Eukaryotic Initiation Factor 3 B (EIF3B) Activates Hepatic Stellate Cells via Upregulating TGF-β1 in Liver Fibrogenesis.
  2. results indicate that p116 plays an essential role in the early stages of mouse development[eIF3 p116]
    Title: Embryonic lethality of mutant mice deficient in the p116 gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in IRES-dependent viral translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in viral translational termination-reinitiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation initiation factor 3 complex, eIF3m IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit B
Names
eIF-3-eta
eIF3 p116
eukaryotic translation initiation factor 3 subunit 9
eukaryotic translation initiation factor 3, subunit 9 (eta)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133916.2 → NP_598677.1  eukaryotic translation initiation factor 3 subunit B

    See identical proteins and their annotated locations for NP_598677.1

    Status: PROVISIONAL

    Source sequence(s)
    AC131670
    Consensus CDS
    CCDS19819.1
    UniProtKB/Swiss-Prot
    Q8JZQ9, Q922K2
    UniProtKB/TrEMBL
    Q8CIJ3
    Related
    ENSMUSP00000098076.4, ENSMUST00000100507.8
    Conserved Domains (4) summary
    PHA03249
    Location:26 → 148
    PHA03249; DNA packaging tegument protein UL25; Provisional
    COG5354
    Location:297 → 796
    COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
    cd12278
    Location:173 → 253
    RRM_eIF3B; RNA recognition motif in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins
    sd00039
    Location:365 → 412
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    140405060..140429113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JZQ9.1 GenPept UniProtKB/Swiss-Prot:Q8JZQ9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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