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Nup62cl nucleoporin 62 C-terminal like [ Mus musculus (house mouse) ]

Gene ID: 279706, updated on 5-Mar-2024

Summary

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Official Symbol
Nup62clprovided by MGI
Official Full Name
nucleoporin 62 C-terminal likeprovided by MGI
Primary source
MGI:MGI:2685565
See related
Ensembl:ENSMUSG00000072944 AllianceGenome:MGI:2685565
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm719
Summary
Predicted to enable phospholipid binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus and protein import into nucleus. Predicted to be part of nuclear pore central transport channel. Orthologous to human NUP62CL (nucleoporin 62 C-terminal like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 71.0) and testis adult (RPKM 5.1) See more
Orthologs
human all
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Genomic context

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Location:
X F1; X 61.35 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (138907551..138963456, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (140006802..140062707, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene microrchidia 4 Neighboring gene predicted gene, 52431 Neighboring gene NMD3 homolog pseudogene Neighboring gene RNA binding motif protein 41 Neighboring gene STARR-seq mESC enhancer starr_48000 Neighboring gene dynein axonemal assembly factor 6 Neighboring gene predicted gene, 39537

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. The transcriptional landscape of the mammalian genome. Carninci P, et al. Science, 2005 Sep 2. PMID 16141072
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nucleoporin-62 C-terminal-like protein
Names
novel Nsp1-like C-terminal region containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081668.1 → NP_001075137.1  nucleoporin-62 C-terminal-like protein

    See identical proteins and their annotated locations for NP_001075137.1

    Status: VALIDATED

    Source sequence(s)
    BC100367, CJ067064
    Consensus CDS
    CCDS53206.1
    UniProtKB/TrEMBL
    A2AG10, A2AG11
    Related
    ENSMUSP00000098772.3, ENSMUST00000101212.9
    Conserved Domains (2) summary
    TIGR02168
    Location:105 → 266
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05064
    Location:65 → 179
    Nsp1_C; Nsp1-like C-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    138907551..138963456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528566.1 → XP_006528629.1  nucleoporin-62 C-terminal-like protein isoform X1

    See identical proteins and their annotated locations for XP_006528629.1

    UniProtKB/TrEMBL
    A2AG10, A2AG11
    Conserved Domains (2) summary
    TIGR02168
    Location:105 → 266
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05064
    Location:65 → 179
    Nsp1_C; Nsp1-like C-terminal region

  2. XM_006528567.2 → XP_006528630.1  nucleoporin-62 C-terminal-like protein isoform X1

    See identical proteins and their annotated locations for XP_006528630.1

    UniProtKB/TrEMBL
    A2AG10, A2AG11
    Conserved Domains (2) summary
    TIGR02168
    Location:105 → 266
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05064
    Location:65 → 179
    Nsp1_C; Nsp1-like C-terminal region

  3. XM_017318521.3 → XP_017174010.1  nucleoporin-62 C-terminal-like protein isoform X2

    UniProtKB/TrEMBL
    A2AG11
    Conserved Domains (1) summary
    pfam05064
    Location:65 → 137
    Nsp1_C; Nsp1-like C-terminal region

  4. XM_006528561.4 → XP_006528624.2  nucleoporin-62 C-terminal-like protein isoform X1

    See identical proteins and their annotated locations for XP_006528624.2

    UniProtKB/TrEMBL
    A2AG10, A2AG11
    Conserved Domains (2) summary
    TIGR02168
    Location:105 → 266
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05064
    Location:65 → 179
    Nsp1_C; Nsp1-like C-terminal region

  5. XM_006528565.3 → XP_006528628.1  nucleoporin-62 C-terminal-like protein isoform X1

    See identical proteins and their annotated locations for XP_006528628.1

    UniProtKB/TrEMBL
    A2AG10, A2AG11
    Conserved Domains (2) summary
    TIGR02168
    Location:105 → 266
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05064
    Location:65 → 179
    Nsp1_C; Nsp1-like C-terminal region

  6. XM_006528563.4 → XP_006528626.2  nucleoporin-62 C-terminal-like protein isoform X1

    See identical proteins and their annotated locations for XP_006528626.2

    UniProtKB/TrEMBL
    A2AG10, A2AG11
    Conserved Domains (2) summary
    TIGR02168
    Location:105 → 266
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05064
    Location:65 → 179
    Nsp1_C; Nsp1-like C-terminal region

  7. XM_006528562.5 → XP_006528625.2  nucleoporin-62 C-terminal-like protein isoform X1

    See identical proteins and their annotated locations for XP_006528625.2

    UniProtKB/TrEMBL
    A2AG10, A2AG11
    Conserved Domains (2) summary
    TIGR02168
    Location:105 → 266
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05064
    Location:65 → 179
    Nsp1_C; Nsp1-like C-terminal region
Nucleotide Protein Strain
Heading Accession and Version

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