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Stkld1 serine/threonine kinase-like domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 279029, updated on 5-Mar-2024

Summary

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Official Symbol
Stkld1provided by MGI
Official Full Name
serine/threonine kinase-like domain containing 1provided by MGI
Primary source
MGI:MGI:2685557
See related
Ensembl:ENSMUSG00000049897 AllianceGenome:MGI:2685557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm711; Sgk071
Summary
Predicted to enable protein serine/threonine kinase activity. Orthologous to human STKLD1 (serine/threonine kinase like domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 36.3), duodenum adult (RPKM 31.6) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 19.12 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26823533..26843508)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26933521..26953496)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 57689 Neighboring gene ribosomal protein L7A Neighboring gene surfeit gene 1 Neighboring gene surfeit gene 2 Neighboring gene surfeit gene 4 Neighboring gene STARR-positive B cell enhancer ABC_E2605 Neighboring gene REX4, 3'-5' exonuclease Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26819876-26820059 Neighboring gene predicted gene, 36649 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC58758

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
serine/threonine kinase-like domain-containing protein STKLD1
Names
likely ortholog of H. sapiens chromosome 9 open reading frame 96 (C9orf96)
probable inactive protein kinase-like protein SgK071 homolog
probable protein kinase-like protein SgK071 homolog
serine/threonine kinase-like domain-containing protein 1
sugen kinase 071

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379463.1 → NP_001366392.1  serine/threonine kinase-like domain-containing protein STKLD1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL773563
    Conserved Domains (1) summary
    smart00220
    Location:4 → 274
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  2. NM_001379464.1 → NP_001366393.1  serine/threonine kinase-like domain-containing protein STKLD1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL773563
    Conserved Domains (1) summary
    smart00220
    Location:4 → 274
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  3. NM_198628.3 → NP_941030.2  serine/threonine kinase-like domain-containing protein STKLD1 isoform 2

    See identical proteins and their annotated locations for NP_941030.2

    Status: VALIDATED

    Source sequence(s)
    AL773563
    Consensus CDS
    CCDS15818.1
    UniProtKB/Swiss-Prot
    A2ALB0, Q80YS9
    Related
    ENSMUSP00000062967.9, ENSMUST00000055406.9
    Conserved Domains (1) summary
    smart00220
    Location:5 → 266
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    26823533..26843508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498110.4 → XP_006498173.1  serine/threonine kinase-like domain-containing protein STKLD1 isoform X1

    See identical proteins and their annotated locations for XP_006498173.1

    Conserved Domains (1) summary
    smart00220
    Location:5 → 278
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  2. XM_006498109.5 → XP_006498172.1  serine/threonine kinase-like domain-containing protein STKLD1 isoform X3

    Conserved Domains (1) summary
    smart00220
    Location:4 → 286
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  3. XM_006498107.4 → XP_006498170.2  serine/threonine kinase-like domain-containing protein STKLD1 isoform X1

    See identical proteins and their annotated locations for XP_006498170.2

    Conserved Domains (1) summary
    smart00220
    Location:5 → 278
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  4. XM_006498112.5 → XP_006498175.2  serine/threonine kinase-like domain-containing protein STKLD1 isoform X5

    Conserved Domains (1) summary
    smart00220
    Location:5 → 278
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  5. XM_006498108.5 → XP_006498171.2  serine/threonine kinase-like domain-containing protein STKLD1 isoform X2

    Conserved Domains (1) summary
    smart00220
    Location:5 → 266
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  6. XM_006498111.5 → XP_006498174.2  serine/threonine kinase-like domain-containing protein STKLD1 isoform X4

    Conserved Domains (1) summary
    smart00220
    Location:5 → 278
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  7. XM_006498113.5 → XP_006498176.2  serine/threonine kinase-like domain-containing protein STKLD1 isoform X6

    See identical proteins and their annotated locations for XP_006498176.2

    UniProtKB/Swiss-Prot
    A2ALB0, Q80YS9
    Conserved Domains (1) summary
    smart00220
    Location:5 → 266
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  8. XM_006498114.1 → XP_006498177.1  serine/threonine kinase-like domain-containing protein STKLD1 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:38 → 134
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YS9.3 GenPept UniProtKB/Swiss-Prot:Q80YS9

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