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Exoc3l exocyst complex component 3-like [ Mus musculus (house mouse) ]

Gene ID: 277978, updated on 3-Apr-2024

Summary

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Official Symbol
Exoc3lprovided by MGI
Official Full Name
exocyst complex component 3-likeprovided by MGI
Primary source
MGI:MGI:3041195
See related
Ensembl:ENSMUSG00000043251 AllianceGenome:MGI:3041195
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Exoc3l1; C730015A04Rik
Summary
Predicted to enable SNARE binding activity. Involved in exocytosis and peptide hormone secretion. Located in secretory granule. Part of exocyst. Is expressed in several structures, including adrenal gland; lung; meninges; olfactory lobe; and vertebral axis musculature. Orthologous to human EXOC3L1 (exocyst complex component 3 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 17.2), lung adult (RPKM 13.6) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 D3; 8 53.04 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106016555..106024258, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105289923..105296966, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene heat shock transcription factor 4 Neighboring gene nucleolar protein 3 (apoptosis repressor with CARD domain) Neighboring gene microtubule associated tyrosine carboxypeptidase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1768 Neighboring gene STARR-positive B cell enhancer ABC_E3797 Neighboring gene uncharacterized LOC102636360 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:107822735-107822970 Neighboring gene E2F transcription factor 4 Neighboring gene engulfment and cell motility 3 Neighboring gene microRNA 328

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion. Saito T, et al. Biomed Res, 2008 Apr. PMID 18480549
  2. Genome-wide identification of endothelial cell-enriched genes in the mouse embryo. Takase H, et al. Blood, 2012 Jul 26. PMID 22535667
  3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Null mutation of exocyst complex component 3-like does not affect vascular development in mice.
    Title: Null mutation of exocyst complex component 3-like does not affect vascular development in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in exocyst localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptide hormone secretion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst IDA
Inferred from Direct Assay
more info
 PubMed 
located_in secretory granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
exocyst complex component 3-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357379.2 → NP_001344308.1  exocyst complex component 3-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124584
    Conserved Domains (1) summary
    cl19885
    Location:1 → 373
    Sec6; Exocyst complex component Sec6

  2. NM_001428421.1 → NP_001415350.1  exocyst complex component 3-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124584
    UniProtKB/Swiss-Prot
    Q3USB8, Q8BI71

  3. NM_001428422.1 → NP_001415351.1  exocyst complex component 3-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124584

  4. NM_001428423.1 → NP_001415352.1  exocyst complex component 3-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124584

  5. NM_177788.6 → NP_808456.1  exocyst complex component 3-like protein isoform 1

    See identical proteins and their annotated locations for NP_808456.1

    Status: VALIDATED

    Source sequence(s)
    AC124584
    Consensus CDS
    CCDS22597.1
    UniProtKB/Swiss-Prot
    Q3USB8, Q8BI71
    UniProtKB/TrEMBL
    Q3T9C8
    Related
    ENSMUSP00000053766.4, ENSMUST00000057855.4
    Conserved Domains (1) summary
    pfam06046
    Location:189 → 722
    Sec6; Exocyst complex component Sec6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106016555..106024258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154085.1 → XP_036009978.1  exocyst complex component 3-like protein isoform X2

    Conserved Domains (1) summary
    cl19885
    Location:1 → 373
    Sec6; Exocyst complex component Sec6

  2. XM_036154084.1 → XP_036009977.1  exocyst complex component 3-like protein isoform X2

    Conserved Domains (1) summary
    cl19885
    Location:1 → 373
    Sec6; Exocyst complex component Sec6

  3. XM_006531070.4 → XP_006531133.1  exocyst complex component 3-like protein isoform X1

    Conserved Domains (1) summary
    pfam06046
    Location:189 → 722
    Sec6; Exocyst complex component Sec6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BI71.1 GenPept UniProtKB/Swiss-Prot:Q8BI71

Gene LinkOut

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