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Commd8 COMM domain containing 8 [ Mus musculus (house mouse) ]

Gene ID: 27784, updated on 5-Mar-2024

Summary

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Official Symbol
Commd8provided by MGI
Official Full Name
COMM domain containing 8provided by MGI
Primary source
MGI:MGI:1343485
See related
Ensembl:ENSMUSG00000029213 AllianceGenome:MGI:1343485
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D5Buc26e
Summary
Predicted to be located in cytosol and nucleoplasm. Orthologous to human COMMD8 (COMM domain containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 7.6), placenta adult (RPKM 7.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Commd8 in Genome Data Viewer
Location:
5 C3.2; 5 38.44 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (72313919..72325532, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (72156576..72168189, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit beta 1 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene 60S ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_13358 Neighboring gene STARR-positive B cell enhancer mm9_chr5:72551776-72552076 Neighboring gene STARR-positive B cell enhancer mm9_chr5:72559343-72559644 Neighboring gene STARR-positive B cell enhancer ABC_E670 Neighboring gene STARR-seq mESC enhancer starr_13361 Neighboring gene STARR-seq mESC enhancer starr_13362 Neighboring gene STARR-seq mESC enhancer starr_13363 Neighboring gene STARR-positive B cell enhancer ABC_E10323 Neighboring gene STARR-positive B cell enhancer ABC_E4761 Neighboring gene ATPase, class V, type 10D Neighboring gene predicted gene, 25768 Neighboring gene corin, serine peptidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex. Shirai T, et al. Sci Immunol, 2023 Mar 31. PMID 37000855
  2. The COMMD3/8 complex determines GRK6 specificity for chemoattractant receptors. Nakai A, et al. J Exp Med, 2019 Jul 1. PMID 31088898, Free PMC Article
  3. A sequence-ready BAC contig of the GABAA receptor gene cluster Gabrg1-Gabra2-Gabrb1 on mouse chromosome 5. Lengeling A, et al. Genome Res, 1999 Aug. PMID 10447508, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC106259

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
COMM domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356611.1 → NP_001343540.1  COMM domain-containing protein 8 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC122915, CB247520
    Conserved Domains (1) summary
    cd04756
    Location:6 → 165
    Commd8; COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

  2. NM_001356612.1 → NP_001343541.1  COMM domain-containing protein 8 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC122915, BY150959
    UniProtKB/TrEMBL
    A0A0G2JEX2
    Related
    ENSMUSP00000142937.2, ENSMUST00000196241.2
    Conserved Domains (1) summary
    cl06336
    Location:25 → 130
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...

  3. NM_001356613.1 → NP_001343542.1  COMM domain-containing protein 8 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate internal exon, which results in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
    Source sequence(s)
    AC122915, AK158078
    UniProtKB/TrEMBL
    Q80UT2
    Conserved Domains (1) summary
    cl06336
    Location:5 → 110
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...

  4. NM_001356614.1 → NP_001343543.1  COMM domain-containing protein 8 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and contains an alternate internal exon, which results in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
    Source sequence(s)
    AC122915, AK017777
    UniProtKB/TrEMBL
    Q80UT2
    Conserved Domains (1) summary
    cl06336
    Location:5 → 110
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...

  5. NM_178599.5 → NP_848714.1  COMM domain-containing protein 8 isoform a

    See identical proteins and their annotated locations for NP_848714.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC122915
    Consensus CDS
    CCDS39108.1
    UniProtKB/Swiss-Prot
    Q9CZG3, Q9D7F6
    UniProtKB/TrEMBL
    Q4QQP1
    Related
    ENSMUSP00000013693.7, ENSMUST00000013693.11
    Conserved Domains (1) summary
    cd04756
    Location:7 → 182
    Commd8; COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    72313919..72325532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254548.1 → XP_030110408.1  COMM domain-containing protein 8 isoform X1

    UniProtKB/TrEMBL
    Q80UT2
    Conserved Domains (1) summary
    cl06336
    Location:5 → 110
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...

  2. XM_036165159.1 → XP_036021052.1  COMM domain-containing protein 8 isoform X1

    UniProtKB/TrEMBL
    Q80UT2
    Conserved Domains (1) summary
    cl06336
    Location:5 → 110
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZG3.1 GenPept UniProtKB/Swiss-Prot:Q9CZG3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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