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Rasl10b RAS-like, family 10, member B [ Mus musculus (house mouse) ]

Gene ID: 276952, updated on 5-Mar-2024

Summary

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Official Symbol
Rasl10bprovided by MGI
Official Full Name
RAS-like, family 10, member Bprovided by MGI
Primary source
MGI:MGI:2685575
See related
Ensembl:ENSMUSG00000020684 AllianceGenome:MGI:2685575
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm729; VTS58635; B230331P10Rik
Summary
Predicted to enable G protein activity and GTP binding activity. Involved in positive regulation of peptide hormone secretion and regulation of systemic arterial blood pressure by atrial natriuretic peptide. Predicted to be located in plasma membrane. Is expressed in several structures, including brain; heart; myotome; neural tube; and retina. Orthologous to human RASL10B (RAS like family 10 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 63.2), cortex adult (RPKM 46.5) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 C; 11 50.3 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83299963..83311865)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83409137..83421039)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8435 Neighboring gene expressed sequence AA465934 Neighboring gene STARR-seq mESC enhancer starr_30193 Neighboring gene expressed sequence AI450353 Neighboring gene peroxisomal biogenesis factor 12 Neighboring gene small nucleolar RNA, C/D box 7 Neighboring gene adaptor-related protein complex 2, beta 1 subunit Neighboring gene STARR-seq mESC enhancer starr_30196 Neighboring gene predicted gene, 23951 Neighboring gene RIKEN cDNA 1700020L24 gene Neighboring gene growth arrest-specific 2 like 2 Neighboring gene matrix metallopeptidase 28 (epilysin)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein. Rybkin II, et al. J Cell Biol, 2007 Nov 5. PMID 17984325, Free PMC Article
  2. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of peptide hormone secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of systemic arterial blood pressure by atrial natriuretic peptide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras-like protein family member 10B
NP_001013404.1
NP_001348495.1
NP_001348496.1
NP_001348497.1
XP_030101915.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013386.3 → NP_001013404.1  ras-like protein family member 10B isoform 1

    See identical proteins and their annotated locations for NP_001013404.1

    Status: VALIDATED

    Source sequence(s)
    AL663096
    Consensus CDS
    CCDS25163.1
    UniProtKB/Swiss-Prot
    Q5SSG5
    Related
    ENSMUSP00000132696.2, ENSMUST00000164425.2
    Conserved Domains (1) summary
    cd04142
    Location:5 → 203
    RRP22; Ras-related protein on chromosome 22 (RRP22) family

  2. NM_001361566.1 → NP_001348495.1  ras-like protein family member 10B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK045997, AK158941, AW456843, BC116407, BY277818
    Consensus CDS
    CCDS25163.1
    UniProtKB/Swiss-Prot
    Q5SSG5
    Related
    ENSMUSP00000021022.4, ENSMUST00000021022.10
    Conserved Domains (1) summary
    cd04142
    Location:5 → 203
    RRP22; Ras-related protein on chromosome 22 (RRP22) family

  3. NM_001361567.1 → NP_001348496.1  ras-like protein family member 10B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK045997, AK158941, AW456843
    Consensus CDS
    CCDS88208.1
    UniProtKB/TrEMBL
    H3BLI7
    Related
    ENSMUSP00000135803.2, ENSMUST00000175848.8
    Conserved Domains (1) summary
    cl21455
    Location:5 → 117
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_001361568.1 → NP_001348497.1  ras-like protein family member 10B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK045997, AK158941, AW456843, BE995698
    Consensus CDS
    CCDS25163.1
    UniProtKB/Swiss-Prot
    Q5SSG5
    Related
    ENSMUSP00000103775.4, ENSMUST00000108140.10
    Conserved Domains (1) summary
    cd04142
    Location:5 → 203
    RRP22; Ras-related protein on chromosome 22 (RRP22) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    83299963..83311865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246055.2 → XP_030101915.1  ras-like protein family member 10B isoform X1

    UniProtKB/Swiss-Prot
    Q5SSG5
    Conserved Domains (1) summary
    cd04142
    Location:5 → 203
    RRP22; Ras-related protein on chromosome 22 (RRP22) family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SSG5.1 GenPept UniProtKB/Swiss-Prot:Q5SSG5

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