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Slfn8 schlafen 8 [ Mus musculus (house mouse) ]

Gene ID: 276950, updated on 11-Apr-2024

Summary

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Official Symbol
Slfn8provided by MGI
Official Full Name
schlafen 8provided by MGI
Primary source
MGI:MGI:2672859
See related
Ensembl:ENSMUSG00000035208 AllianceGenome:MGI:2672859
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mSLFN8
Summary
Enables endoribonuclease activity. Involved in rRNA catabolic process and tRNA catabolic process. Predicted to be located in cytosol; nucleoplasm; and site of DNA damage. Orthologous to human SLFN11 (schlafen family member 11) and SLFN13 (schlafen family member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 1.4), thymus adult (RPKM 1.2) and 24 other tissues See more
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Genomic context

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Location:
11 C; 11 50.3 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (82892984..82911636, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83002125..83020810, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SET domain-containing protein 8 pseudogene Neighboring gene schlafen 9 Neighboring gene microRNA 7679 Neighboring gene schlafen 10, pseudogene Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30184 Neighboring gene STARR-positive B cell enhancer ABC_E10699 Neighboring gene STARR-positive B cell enhancer ABC_E8434

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control. Yang JY, et al. Nat Commun, 2018 Mar 21. PMID 29563550, Free PMC Article
  2. Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis. Nakagawa K, et al. Int Immunol, 2018 Mar 8. PMID 29528433
  3. Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma. Mavrommatis E, et al. J Biol Chem, 2013 Nov 15. PMID 24089532, Free PMC Article
  4. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Geserick P, et al. Int Immunol, 2004 Oct. PMID 15351786
  5. Subcellular localization of the Schlafen protein family. Neumann B, et al. Biochem Biophys Res Commun, 2008 May 23. PMID 18355440

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.
    Title: Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.
  2. We demonstrated that Slfn8-/- mice were resistant to the development of EAE.
    Title: Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis.
  3. several mouse Slfn genes are up-regulated in response to IFN treatment of mouse melanoma and renal cell carcinoma cells, including Slfn1, Slfn2, Slfn4, Slfn5, and Slfn8.
    Title: Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma.
  4. functional participation of slfn8 in the regulatory networks governing T cell development and growth appears to be cell type specific
    Title: Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC30719

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA decay IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA decay ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
schlafen family member 8
Names
Schlafen family member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167743.1 → NP_001161215.1  schlafen family member 8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks one exon in the 5' UTR and one exon in the CDS, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL603745, BC152549
    Consensus CDS
    CCDS48869.1
    UniProtKB/TrEMBL
    A0A1G5SJK5, E9Q0R4
    Related
    ENSMUSP00000103787.3, ENSMUST00000108152.9
    Conserved Domains (2) summary
    PHA02782
    Location:45 → 346
    PHA02782; hypothetical protein; Provisional
    pfam04326
    Location:205 → 316
    AlbA_2; Putative DNA-binding domain

  2. NM_181545.4 → NP_853523.2  schlafen family member 8 isoform 1

    See identical proteins and their annotated locations for NP_853523.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL603745, AY261798
    Consensus CDS
    CCDS25155.1
    UniProtKB/Swiss-Prot
    A0A0A0MQG0, B1ARD8, F6RTS1, Q3UBN9, Q7TMF1
    UniProtKB/TrEMBL
    A0A1G5SJB6, Q7TMF0
    Related
    ENSMUSP00000040060.9, ENSMUST00000038141.15
    Conserved Domains (4) summary
    PHA02782
    Location:45 → 346
    PHA02782; hypothetical protein; Provisional
    pfam13401
    Location:595 → 678
    AAA_22; AAA domain
    pfam09848
    Location:595 → 765
    DUF2075; Uncharacterized conserved protein (DUF2075)
    pfam13538
    Location:852 → 896
    UvrD_C_2; UvrD-like helicase C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    82892984..82911636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156744.1 → XP_036012637.1  schlafen family member 8 isoform X1

    UniProtKB/Swiss-Prot
    A0A0A0MQG0, B1ARD8, F6RTS1, Q3UBN9, Q7TMF1
    UniProtKB/TrEMBL
    A0A1G5SJB6, Q7TMF0
    Related
    ENSMUSP00000090513.5, ENSMUST00000092838.11
    Conserved Domains (4) summary
    PHA02782
    Location:45 → 346
    PHA02782; hypothetical protein; Provisional
    pfam13401
    Location:595 → 678
    AAA_22; AAA domain
    pfam09848
    Location:595 → 765
    DUF2075; Uncharacterized conserved protein (DUF2075)
    pfam13538
    Location:852 → 896
    UvrD_C_2; UvrD-like helicase C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1ARD8.1 GenPept UniProtKB/Swiss-Prot:B1ARD8

Gene LinkOut

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