Smtnl2 smoothelin-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Smtnl2provided by MGI
Official Full Name: smoothelin-like 2provided by MGI
Primary source: MGI:MGI:2442764
See related: Ensembl:ENSMUSG00000045667 AllianceGenome:MGI:2442764
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D130058I21Rik
Summary: Predicted to enable protein phosphatase 1 binding activity and tropomyosin binding activity. Predicted to be involved in actin cytoskeleton organization and positive regulation of vasoconstriction. Predicted to be part of filamentous actin. Predicted to be active in I band; M band; and microtubule organizing center. Is expressed in heart. Orthologous to human SMTNL2 (smoothelin like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 9.3), mammary gland adult (RPKM 6.8) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B4; 11 44.15 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (72279989..72302539, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (72389163..72411713, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Smtnl2 regulates apoptotic germ cell clearance and lactate metabolism in mouse Sertoli cells.
Title: Smtnl2 regulates apoptotic germ cell clearance and lactate metabolism in mouse Sertoli cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Smtnl2 (e-PCR), detects polymorphism
- UniSTS:502757

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of filamentous actin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: smoothelin-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177776.3 → NP_808444.1 smoothelin-like protein 2

See identical proteins and their annotated locations for NP_808444.1

Status: PROVISIONAL

Source sequence(s)

AL662812

Consensus CDS

CCDS24985.1

UniProtKB/Swiss-Prot

Q8CI12

UniProtKB/TrEMBL

Q5F247

Related

ENSMUSP00000059043.7, ENSMUST00000050226.7

Conserved Domains (2) summary

cd00014
Location:349 → 453

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cl01090
Location:56 → 89

SlyX; SlyX

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

72279989..72302539 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156740.1 → XP_036012633.1 smoothelin-like protein 2 isoform X1

Conserved Domains (1) summary

cd21261
Location:244 → 350

CH_SMTNL2; calponin homology (CH) domain found in smoothelin-like protein 2
XM_036156742.1 → XP_036012635.1 smoothelin-like protein 2 isoform X4

Conserved Domains (1) summary

cd21261
Location:226 → 332

CH_SMTNL2; calponin homology (CH) domain found in smoothelin-like protein 2
XM_006533470.3 → XP_006533533.1 smoothelin-like protein 2 isoform X5

Conserved Domains (1) summary

pfam00307
Location:220 → 325

CH; Calponin homology (CH) domain
XM_036156743.1 → XP_036012636.1 smoothelin-like protein 2 isoform X6

Conserved Domains (1) summary

cd21261
Location:160 → 266

CH_SMTNL2; calponin homology (CH) domain found in smoothelin-like protein 2
XM_036156741.1 → XP_036012634.1 smoothelin-like protein 2 isoform X3

Conserved Domains (1) summary

cd21261
Location:230 → 336

CH_SMTNL2; calponin homology (CH) domain found in smoothelin-like protein 2
XM_006533469.4 → XP_006533532.1 smoothelin-like protein 2 isoform X2

Conserved Domains (1) summary

pfam00307
Location:243 → 348

CH; Calponin homology (CH) domain