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Eif5a eukaryotic translation initiation factor 5A [ Mus musculus (house mouse) ]

Gene ID: 276770, updated on 11-Apr-2024

Summary

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Official Symbol
Eif5aprovided by MGI
Official Full Name
eukaryotic translation initiation factor 5Aprovided by MGI
Primary source
MGI:MGI:106248
See related
Ensembl:ENSMUSG00000078812 AllianceGenome:MGI:106248
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eif4d; Eif5a1; eIF-4D; eIF-5A; eIF-5A1; eIF-5A-1; D19Wsu54e
Summary
This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in liver E14 (RPKM 325.9), liver E14.5 (RPKM 312.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B3; 11 42.92 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69807538..69812784, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69916712..69921958, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2810408A11 gene Neighboring gene STARR-positive B cell enhancer ABC_E7007 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69715057-69715244 Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene STARR-positive B cell enhancer ABC_E5243 Neighboring gene G protein pathway suppressor 2 Neighboring gene STARR-positive B cell enhancer ABC_E8420 Neighboring gene STARR-positive B cell enhancer ABC_E1831 Neighboring gene Y box protein 2 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 4 Neighboring gene STARR-positive B cell enhancer ABC_E9140

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. Puleston DJ, et al. Cell Metab, 2019 Aug 6. PMID 31130465, Free PMC Article
  2. The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice. Maier B, et al. J Clin Invest, 2010 Jun. PMID 20501948, Free PMC Article
  3. Independent roles of eIF5A and polyamines in cell proliferation. Nishimura K, et al. Biochem J, 2005 Feb 1. PMID 15377278, Free PMC Article
  4. New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape. Schultz CR, et al. Biol Open, 2023 Mar 15. PMID 36848144, Free PMC Article
  5. Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development. Nishimura K, et al. Amino Acids, 2012 Feb. PMID 21850436, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia.
    Title: Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia.
  2. Targeted inhibition of eIF5A[hpu] suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer.
    Title: Targeted inhibition of eIF5A(hpu) suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer.
  3. Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.
    Title: Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.
  4. Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.
    Title: Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.
  5. Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice.
    Title: Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice.
  6. The eIF5A (eIF5A(H)) promotes the efficient expression of a subset of mitochondrial proteins involved in the TCA cycle and oxidative phosphorylation (OXPHOS).
    Title: Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation.
  7. Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
    Title: Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
  8. our results provide the first genetic evidence that the hypusine modification in eIF-5A is crucial for homeostasis in mammals
    Title: Biological Relevance and Therapeutic Potential of the Hypusine Modification System.
  9. knockout of either the eIF5A-1 gene (Eif5a) or of the deoxyhypusine synthase gene (Dhps) caused early embryonic lethality in mice, indicating the essential nature of both eIF5A-1 and deoxyhypusine synthase in mammalian development
    Title: Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development.
  10. These results point to a new functional role for eIF5A, relating it to embryogenesis, development, and cell differentiation.
    Title: Evidences of a role for eukaryotic translation initiation factor 5A (eIF5A) in mouse embryogenesis and cell differentiation.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6725

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables U6 snRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of translational termination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in annulate lamellae ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 5A-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166589.1 → NP_001160061.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160061.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also referred to as variant BD) represents the longest transcript. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK010183, AK011306, AK218644, AL596185, CX237346
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242, Q5NCX0, Q78NR3
    UniProtKB/TrEMBL
    A0A0A0MQM0
    Related
    ENSMUSP00000047008.4, ENSMUST00000043419.10
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

  2. NM_001166590.1 → NP_001160062.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160062.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also referred to as variant D) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK011306, AK218644, AL596185, CX237346
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242, Q5NCX0, Q78NR3
    UniProtKB/TrEMBL
    A0A0A0MQM0
    Related
    ENSMUSP00000104250.2, ENSMUST00000108610.8
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

  3. NM_001166591.1 → NP_001160063.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160063.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also referred to as variant BE) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK010183, AK011306, AK218644, AL596185
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242, Q5NCX0, Q78NR3
    UniProtKB/TrEMBL
    A0A0A0MQM0
    Related
    ENSMUSP00000067077.5, ENSMUST00000070996.11
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

  4. NM_001166592.1 → NP_001160064.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160064.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also referred to as variant CD) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK011306, AK218644, CX218195, CX237346
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242, Q5NCX0, Q78NR3
    UniProtKB/TrEMBL
    A0A0A0MQM0
    Related
    ENSMUSP00000104251.2, ENSMUST00000108611.8
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

  5. NM_001166593.1 → NP_001160065.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160065.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also referred to as variant AE) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK011306, AK218644, AL596185
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242, Q5NCX0, Q78NR3
    UniProtKB/TrEMBL
    A0A0A0MQM0
    Related
    ENSMUSP00000068651.4, ENSMUST00000071026.10
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

  6. NM_001166594.1 → NP_001160066.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160066.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7, also referred to as variant C) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK011306, AK218644, CX218195, CX237346
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242, Q5NCX0, Q78NR3
    UniProtKB/TrEMBL
    A0A0A0MQM0
    Related
    ENSMUSP00000104252.2, ENSMUST00000108612.8
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

  7. NM_001166595.1 → NP_001160067.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160067.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK011306, AK218644, AL596185
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242, Q5NCX0, Q78NR3
    UniProtKB/TrEMBL
    A0A0A0MQM0
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

  8. NM_001166596.1 → NP_001160068.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_001160068.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK011306, AK218644, AL596185, CX237346
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242, Q5NCX0, Q78NR3
    UniProtKB/TrEMBL
    A0A0A0MQM0
    Related
    ENSMUSP00000132717.2, ENSMUST00000164359.8
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

  9. NM_181582.4 → NP_853613.1  eukaryotic translation initiation factor 5A-1

    See identical proteins and their annotated locations for NP_853613.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also referred to as variant B) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AI850684, AK010183, AK011306, AK218644, AL596185
    Consensus CDS
    CCDS24923.1
    UniProtKB/Swiss-Prot
    P63242, Q5NCX0, Q78NR3
    UniProtKB/TrEMBL
    A0A0A0MQM0
    Related
    ENSMUSP00000104253.4, ENSMUST00000108613.10
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69807538..69812784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246050.2 → XP_030101910.1  eukaryotic translation initiation factor 5A-1 isoform X1

    UniProtKB/Swiss-Prot
    P63242, Q5NCX0, Q78NR3
    UniProtKB/TrEMBL
    A0A0A0MQM0
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

  2. XM_011249058.4 → XP_011247360.1  eukaryotic translation initiation factor 5A-1 isoform X1

    See identical proteins and their annotated locations for XP_011247360.1

    UniProtKB/Swiss-Prot
    P63242, Q5NCX0, Q78NR3
    UniProtKB/TrEMBL
    A0A0A0MQM0
    Related
    ENSMUSP00000104249.2, ENSMUST00000108609.8
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

  3. XM_030246051.1 → XP_030101911.1  eukaryotic translation initiation factor 5A-1 isoform X1

    UniProtKB/Swiss-Prot
    P63242, Q5NCX0, Q78NR3
    UniProtKB/TrEMBL
    A0A0A0MQM0
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

  4. XM_036156739.1 → XP_036012632.1  eukaryotic translation initiation factor 5A-1 isoform X1

    UniProtKB/Swiss-Prot
    P63242, Q5NCX0, Q78NR3
    UniProtKB/TrEMBL
    A0A0A0MQM0
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63242.2 GenPept UniProtKB/Swiss-Prot:P63242

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