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Slc14a2 solute carrier family 14 (urea transporter), member 2 [ Mus musculus (house mouse) ]

Gene ID: 27411, updated on 11-Apr-2024

Summary

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Official Symbol
Slc14a2provided by MGI
Official Full Name
solute carrier family 14 (urea transporter), member 2provided by MGI
Primary source
MGI:MGI:1351653
See related
Ensembl:ENSMUSG00000024552 AllianceGenome:MGI:1351653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UT-A1; UT-A3
Summary
Enables urea transmembrane transporter activity. Predicted to be involved in urea transmembrane transport. Predicted to be integral component of membrane. Is expressed in metanephros and nervous system. Orthologous to human SLC14A2 (solute carrier family 14 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 38.3), testis adult (RPKM 8.0) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
18 E3; 18 52.53 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (78189359..78640165, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (78146144..78596950, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45139 Neighboring gene sialic acid binding Ig-like lectin 15 Neighboring gene solute carrier family 14 (urea transporter), member 1 Neighboring gene predicted gene, 36338 Neighboring gene STARR-positive B cell enhancer mm9_chr18:78408899-78409200 Neighboring gene STARR-seq mESC enhancer starr_45142 Neighboring gene STARR-seq mESC enhancer starr_45143 Neighboring gene VISTA enhancer mm173 Neighboring gene predicted gene, 54027 Neighboring gene STARR-seq mESC enhancer starr_45144 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene RIKEN cDNA 4931439C15 gene Neighboring gene STARR-seq mESC enhancer starr_45145 Neighboring gene predicted gene, 26430 Neighboring gene STARR-seq mESC enhancer starr_45147 Neighboring gene predicted gene, 23895 Neighboring gene SET binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_45148 Neighboring gene STARR-seq mESC enhancer starr_45149 Neighboring gene STARR-positive B cell enhancer ABC_E1963 Neighboring gene STARR-seq mESC enhancer starr_45150 Neighboring gene STARR-seq mESC enhancer starr_45151 Neighboring gene STARR-positive B cell enhancer ABC_E7614

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Purinergic signaling is enhanced in the absence of UT-A1 and UT-A3. Himmel NJ, et al. Physiol Rep, 2021 Jan. PMID 33369887, Free PMC Article
  2. The urea transporter UT-A1 plays a predominant role in a urea-dependent urine-concentrating mechanism. Geng X, et al. J Biol Chem, 2020 Jul 17. PMID 32461256, Free PMC Article
  3. UT-A1/A3 knockout mice show reduced fibrosis following unilateral ureteral obstruction. Rianto F, et al. Am J Physiol Renal Physiol, 2020 May 1. PMID 32174141, Free PMC Article
  4. Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC. Rogers RT, et al. Am J Physiol Renal Physiol, 2019 Mar 1. PMID 30539654, Free PMC Article
  5. Urea transporter knockout mice and their renal phenotypes. Fenton RA, et al. Subcell Biochem, 2014. PMID 25298343

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Purinergic signaling is enhanced in the absence of UT-A1 and UT-A3.
    Title: Purinergic signaling is enhanced in the absence of UT-A1 and UT-A3.
  2. Water transport mediated by murine urea transporters: implications for urine concentration mechanisms.
    Title: Water transport mediated by murine urea transporters: implications for urine concentration mechanisms.
  3. The urea transporter UT-A1 plays a predominant role in a urea-dependent urine-concentrating mechanism.
    Title: The urea transporter UT-A1 plays a predominant role in a urea-dependent urine-concentrating mechanism.
  4. Reduced UT-A1/A3 activity reduces the severity of renal fibrosis following unilateral ureteral obstruction.
    Title: UT-A1/A3 knockout mice show reduced fibrosis following unilateral ureteral obstruction.
  5. In summary, loss of both UT-A1 and UT-A3 (but not UT-A3 alone) causes elevated medullary NO production and salt wasting
    Title: Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC.
  6. Functional deficiency of all UTs caused a urea-selective urine-concentrating defect with little physiological abnormality in extrarenal organs.
    Title: Generation and phenotypic analysis of mice lacking all urea transporters.
  7. results suggest that GSK3 may in part modulate the hypertonic-induced intracellular UT-A1 redistribution and its accumulation on the plasma membrane, which may constitute another mechanism by which GSK3 modulates urine concentration
    Title: Glycogen Synthase Kinase-3 Modulates Hyperosmotic-Induced Urea Transporter A1 Relocation in the Inner Medullary Collecting Duct Cells.
  8. UT2 is a negative regulator shared across STAT3 and mTORC2 signaling cascades, functioning as a tumor suppressor in hematologic malignancies driven by those pathways.
    Title: Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy.
  9. Studies indicate that urea transporter Slc14a2 (UT-A1/3) knockout mouse models showed the essential role of urea for producing maximally concentrated urine.
    Title: Urea transporter knockout mice and their renal phenotypes.
  10. It is concluded that NaCl and urea synergistically induce the expression of UTA2 rather than AQP2 in mIMCD3 cells, and hyperosmolality probably mediates the expression of AQP2 and UTA2 through different mechanisms.
    Title: Effects of hyperosmolality on expression of urea transporter A2 and aquaporin 2 in mouse medullary collecting duct cells.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC183591

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables urea transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables urea transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in urea transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within urea transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in urea transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
urea transporter 2
Names
solute carrier family 14 member 2
urea transporter, kidney

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110273.2 → NP_001103743.1  urea transporter 2 isoform c

    See identical proteins and their annotated locations for NP_001103743.1

    Status: VALIDATED

    Source sequence(s)
    AC112792
    Consensus CDS
    CCDS89283.1
    UniProtKB/TrEMBL
    Q8BMD1
    Related
    ENSMUSP00000157855.2, ENSMUST00000237290.2
    Conserved Domains (1) summary
    pfam03253
    Location:58 → 353
    UT; Urea transporter

  2. NM_001110274.2 → NP_001103744.1  urea transporter 2 isoform d

    See identical proteins and their annotated locations for NP_001103744.1

    Status: VALIDATED

    Source sequence(s)
    AC112792
    Consensus CDS
    CCDS50331.1
    UniProtKB/TrEMBL
    A0A0R4J213
    Related
    ENSMUSP00000126416.2, ENSMUST00000163367.3
    Conserved Domains (1) summary
    pfam03253
    Location:1 → 274
    UT; Urea transporter

  3. NM_030683.4 → NP_109608.1  urea transporter 2 isoform b

    See identical proteins and their annotated locations for NP_109608.1

    Status: VALIDATED

    Source sequence(s)
    AC112792, AC140455, AC145554, AC151578
    Consensus CDS
    CCDS89284.1
    UniProtKB/TrEMBL
    A0A494BAL3
    Related
    ENSMUSP00000158141.2, ENSMUST00000235389.2
    Conserved Domains (1) summary
    pfam03253
    Location:128 → 412
    UT; Urea transporter

  4. NM_207651.4 → NP_997534.2  urea transporter 2 isoform a

    See identical proteins and their annotated locations for NP_997534.2

    Status: VALIDATED

    Source sequence(s)
    AC112792, AC140455, AC145554, AC151578
    Consensus CDS
    CCDS29361.1
    UniProtKB/Swiss-Prot
    B2RWS5, Q8K5D0, Q8R4T9, Q9ES04, Q9ES05
    UniProtKB/TrEMBL
    G5E849
    Related
    ENSMUSP00000157851.2, ENSMUST00000237674.2
    Conserved Domains (1) summary
    pfam03253
    Location:591 → 886
    UT; Urea transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    78189359..78640165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526488.1 → XP_006526551.1  urea transporter 2 isoform X1

    Conserved Domains (1) summary
    pfam03253
    Location:128 → 384
    UT; Urea transporter

  2. XM_017317915.1 → XP_017173404.1  urea transporter 2 isoform X2

    Conserved Domains (1) summary
    pfam03253
    Location:1 → 246
    UT; Urea transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4T9.2 GenPept UniProtKB/Swiss-Prot:Q8R4T9

Gene LinkOut

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