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Abcg3 ATP binding cassette subfamily G member 3 [ Mus musculus (house mouse) ]

Gene ID: 27405, updated on 11-Apr-2024

Summary

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Official Symbol
Abcg3provided by MGI
Official Full Name
ATP binding cassette subfamily G member 3provided by MGI
Primary source
MGI:MGI:1351624
See related
Ensembl:ENSMUSG00000029299 AllianceGenome:MGI:1351624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mxr2; Abcp2
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It lacks several highly conserved residues found in other ATP-binding proteins; this suggests that this protein may not bind ATP and may require dimerization with another subunit to form a functional ATP-transporter. The function of this gene has not yet been determined; however, high levels of expression in the thymus and spleen suggest a potential role in the transport of specific peptides or hydrophobic compounds from lymphocytes. [provided by RefSeq, Jul 2008]
Expression
Biased expression in thymus adult (RPKM 4.1), spleen adult (RPKM 3.8) and 9 other tissues See more
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Genomic context

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See Abcg3 in Genome Data Viewer
Location:
5 E5; 5 50.68 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (105082924..105130675, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (104935057..104982811, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13843 Neighboring gene predicted gene, 29714 Neighboring gene STARR-seq mESC enhancer starr_13844 Neighboring gene predicted gene, 29716 Neighboring gene predicted gene, 24097 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:105411589-105411825 Neighboring gene STARR-seq mESC enhancer starr_13846 Neighboring gene Sec61 beta subunit pseudogene Neighboring gene guanylate-binding protein 8 Neighboring gene STARR-seq mESC enhancer starr_13847

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An ATP-binding cassette gene (ABCG3) closely related to the multidrug transporter ABCG2 (MXR/ABCP) has an unusual ATP-binding domain. Mickley L, et al. Mamm Genome, 2001 Jan. PMID 11178751
  2. In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. Olszewski MA, et al. J Interferon Cytokine Res, 2006 May. PMID 16689661
  3. Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus. Schriml LM, et al. Genomics, 2000 Feb 15. PMID 10708515
  4. Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains. Wergedal JE, et al. J Lipid Res, 2007 Aug. PMID 17496333
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ABC-type xenobiotic transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables efflux transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables efflux transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables riboflavin transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables riboflavin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables urate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular detoxification ISO
Inferred from Sequence Orthology
more info
  
involved_in renal urate salt excretion ISO
Inferred from Sequence Orthology
more info
  
involved_in riboflavin transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transepithelial transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in urate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic transport across blood-brain barrier ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-binding cassette sub-family G member 3
Names
ATP-binding cassette, sub-family G (WHITE), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419102.1 → NP_001406031.1  ATP-binding cassette sub-family G member 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125005
    UniProtKB/TrEMBL
    D3Z0Z4
    Related
    ENSMUSP00000120179.2, ENSMUST00000130644.2

  2. NM_030239.3 → NP_084515.2  ATP-binding cassette sub-family G member 3 isoform 1

    See identical proteins and their annotated locations for NP_084515.2

    Status: VALIDATED

    Source sequence(s)
    AC125005
    Consensus CDS
    CCDS19488.1
    UniProtKB/Swiss-Prot
    Q8BKI5, Q99P81
    Related
    ENSMUSP00000031239.7, ENSMUST00000031239.13
    Conserved Domains (3) summary
    TIGR00955
    Location:64 → 642
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    pfam01061
    Location:372 → 576
    ABC2_membrane; ABC-2 type transporter
    cl21455
    Location:35 → 261
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    105082924..105130675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320905.2 → XP_017176394.1  ATP-binding cassette sub-family G member 3 isoform X1

    Conserved Domains (1) summary
    TIGR00955
    Location:137 → 670
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

  2. XM_017320906.2 → XP_017176395.1  ATP-binding cassette sub-family G member 3 isoform X2

    Conserved Domains (2) summary
    pfam12183
    Location:19 → 71
    NotI; Restriction endonuclease NotI
    cl38936
    Location:108 → 334
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99P81.2 GenPept UniProtKB/Swiss-Prot:Q99P81

Gene LinkOut

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