Abca8b ATP-binding cassette, sub-family A member 8b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abca8bprovided by MGI
Official Full Name: ATP-binding cassette, sub-family A member 8bprovided by MGI
Primary source: MGI:MGI:1351668
See related: Ensembl:ENSMUSG00000020620 AllianceGenome:MGI:1351668
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Abca8
Summary: Predicted to enable ABC-type xenobiotic transporter activity and lipid transporter activity. Predicted to be involved in several processes, including cholesterol efflux; positive regulation of cholesterol efflux; and sphingomyelin biosynthetic process. Located in basolateral plasma membrane. Is expressed in several structures, including alimentary system; eye; limb; male reproductive gland or organ; and nervous system. Orthologous to human ABCA8 (ATP binding cassette subfamily A member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 22.7), liver adult (RPKM 4.4) and 12 other tissues See more
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Genomic context

Location:: 11 E1; 11 72.88 cM

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (109823016..109886642, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (109932206..109996274, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study results suggest that mABCA8b/ABCA8 functions as a sinusoidal efflux transporter for at least cholesterol and taurocholate in mouse and human liver.
Title: ATP-Binding Cassette Transporter A Subfamily 8 Is a Sinusoidal Efflux Transporter for Cholesterol and Taurocholate in Mouse and Human Liver.
ABCA8 facilitates cholesterol efflux and modulates HDL-cholesterol levels.
Title: ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH46167 (e-PCR)
- UniSTS:24459

Abca8b (e-PCR), detects polymorphism
- UniSTS:256459

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ABC-type transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type xenobiotic transporter activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in lipid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in sphingomyelin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within xenobiotic transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ABC-type organic anion transporter ABCA8B

Names: ATP-binding cassette sub-family A member 8-B; ATP-binding cassette, sub-family A (ABC1), member 8b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362749.2 → NP_001349678.1 ABC-type organic anion transporter ABCA8B isoform 2

Status: VALIDATED

Source sequence(s)

AL807245

Consensus CDS

CCDS88278.1

Related

ENSMUSP00000102280.3, ENSMUST00000106669.3

Conserved Domains (1) summary

TIGR01257
Location:322 → 1534

rim_protein; retinal-specific rim ABC transporter
NM_001425480.1 → NP_001412409.1 ABC-type organic anion transporter ABCA8B isoform 1

Status: VALIDATED

Source sequence(s)

AL807245

UniProtKB/Swiss-Prot

A2AM55, Q69ZY4, Q8BRQ1, Q8K440, Q9JL38

UniProtKB/TrEMBL

A2AM56
NM_001425481.1 → NP_001412410.1 ABC-type organic anion transporter ABCA8B isoform 3

Status: VALIDATED

Source sequence(s)

AL807245
NM_013851.4 → NP_038879.2 ABC-type organic anion transporter ABCA8B isoform 1

See identical proteins and their annotated locations for NP_038879.2

Status: VALIDATED

Source sequence(s)

AL807245

Consensus CDS

CCDS25587.1

UniProtKB/Swiss-Prot

A2AM55, Q69ZY4, Q8BRQ1, Q8K440, Q9JL38

UniProtKB/TrEMBL

A2AM56

Related

ENSMUSP00000020948.9, ENSMUST00000020948.15

Conserved Domains (1) summary

TIGR01257
Location:265 → 1596

rim_protein; retinal-specific rim ABC transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

109823016..109886642 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533461.5 → XP_006533524.1 ABC-type organic anion transporter ABCA8B isoform X3

Conserved Domains (1) summary

TIGR01257
Location:265 → 1561

rim_protein; retinal-specific rim ABC transporter
XM_006533463.3 → XP_006533526.1 ABC-type organic anion transporter ABCA8B isoform X4

See identical proteins and their annotated locations for XP_006533526.1

UniProtKB/Swiss-Prot

Q8K440

Conserved Domains (1) summary

TIGR01257
Location:322 → 1534

rim_protein; retinal-specific rim ABC transporter
XM_030246047.1 → XP_030101907.1 ABC-type organic anion transporter ABCA8B isoform X6

Conserved Domains (2) summary

TIGR01257
Location:277 → 818

rim_protein; retinal-specific rim ABC transporter

cd03263
Location:505 → 726

ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
XM_006533464.5 → XP_006533527.1 ABC-type organic anion transporter ABCA8B isoform X5

Conserved Domains (2) summary

TIGR01257
Location:265 → 789

rim_protein; retinal-specific rim ABC transporter

cd03263
Location:479 → 702

ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A