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Skp2 S-phase kinase-associated protein 2 [ Mus musculus (house mouse) ]

Gene ID: 27401, updated on 21-Apr-2024

Summary

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Official Symbol
Skp2provided by MGI
Official Full Name
S-phase kinase-associated protein 2provided by MGI
Primary source
MGI:MGI:1351663
See related
Ensembl:ENSMUSG00000054115 AllianceGenome:MGI:1351663
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p45; FWD1; FBXL1; 4930500A04Rik
Summary
Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including cellular protein metabolic process; mitotic cell cycle phase transition; and positive regulation of intracellular estrogen receptor signaling pathway. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including blastocyst; compacted morula; and retina nuclear layer. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 26.1), limb E14.5 (RPKM 12.8) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 A1; 15 3.84 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (9112070..9155512, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (9111982..9155425, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RAN binding protein 3-like Neighboring gene predicted gene, 53883 Neighboring gene STARR-positive B cell enhancer ABC_E1904 Neighboring gene STARR-seq mESC enhancer starr_37924 Neighboring gene NAD kinase 2, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E3131 Neighboring gene LMBR1 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_37931 Neighboring gene STARR-seq mESC enhancer starr_37932 Neighboring gene UDP glycosyltransferases 3 family pseudogene Neighboring gene UDP glycosyltransferases 3 family, polypeptide A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MicroRNA-365 accelerates cardiac hypertrophy by inhibiting autophagy via the modulation of Skp2 expression. Wu H, et al. Biochem Biophys Res Commun, 2017 Mar 4. PMID 28130111
  2. Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model. Li X, et al. Oncotarget, 2015 Dec 8. PMID 26497688, Free PMC Article
  3. The miR-30 Family Inhibits Pulmonary Vascular Hyperpermeability in the Premetastatic Phase by Direct Targeting of Skp2. Qi F, et al. Clin Cancer Res, 2015 Jul 1. PMID 25810374
  4. Inhibition of S-phase kinase-associated protein 2 (Skp2) reprograms and converts diabetogenic T cells to Foxp3+ regulatory T cells. Wang D, et al. Proc Natl Acad Sci U S A, 2012 Jun 12. PMID 22645357, Free PMC Article
  5. The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs. Rodriguez S, et al. Blood, 2011 Jun 16. PMID 21502543, Free PMC Article

See all (134) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SKP2 Knockout in Rb1/p53-Deficient Mouse Models of Osteosarcoma Induces Immune Infiltration and Drives a Transcriptional Program with a Favorable Prognosis.
    Title: SKP2 Knockout in Rb1/p53-Deficient Mouse Models of Osteosarcoma Induces Immune Infiltration and Drives a Transcriptional Program with a Favorable Prognosis.
  2. A critical role of the endothelial S-phase kinase-associated protein 2/phosphatase and tensin homologue axis in angiogenesis and psoriasis.
    Title: A critical role of the endothelial S-phase kinase-associated protein 2/phosphatase and tensin homologue axis in angiogenesis and psoriasis.
  3. Immunosensitivity mediated by downregulated AKT1-SKP2 induces anti-PD-1-associated thyroid immune injury.
    Title: Immunosensitivity mediated by downregulated AKT1-SKP2 induces anti-PD-1-associated thyroid immune injury.
  4. AhR activation promotes Treg cell generation by enhancing Lkb1-mediated fatty acid oxidation via the Skp2/K63-ubiquitination pathway.
    Title: AhR activation promotes Treg cell generation by enhancing Lkb1-mediated fatty acid oxidation via the Skp2/K63-ubiquitination pathway.
  5. SCF-SKP2 E3 ubiquitin ligase links mTORC1/ER stress/ISR with YAP activation in murine renal cystogenesis.
    Title: SCF-SKP2 E3 ubiquitin ligase links mTORC1/ER stress/ISR with YAP activation in murine renal cystogenesis.
  6. The role of SCF(Skp2) and SCF(beta-TrCP1/2) in the cerebellar granule cell precursors.
    Title: The role of SCF(Skp2) and SCF(β-TrCP1/2) in the cerebellar granule cell precursors.
  7. S-Phase Kinase-associated Protein-2 Rejuvenates Senescent Endothelial Progenitor Cells and Induces Angiogenesis in Vivo.
    Title: S-Phase Kinase-associated Protein-2 Rejuvenates Senescent Endothelial Progenitor Cells and Induces Angiogenesis in Vivo.
  8. MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2.
    Title: MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2.
  9. Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development.
    Title: Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development.
  10. Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL.
    Title: Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL.
Submit: New GeneRIF Correction See all GeneRIFs (83)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (6) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102075, MGC116668, 4930500A04Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-like ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G2/M transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of intracellular estrogen receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell cycle IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
S-phase kinase-associated protein 2
Names
F-box protein Skp2
F-box/WD-40 protein 1
cyclin A/CDK2-associated protein p45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285980.1 → NP_001272909.1  S-phase kinase-associated protein 2 isoform c

    See identical proteins and their annotated locations for NP_001272909.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks part of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC139209, AK006221, AK015652, BC092236
    Consensus CDS
    CCDS79360.1
    UniProtKB/TrEMBL
    A0A087WQ11
    Related
    ENSMUSP00000139997.2, ENSMUST00000190131.2
    Conserved Domains (3) summary
    cd09293
    Location:158 → 310
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:102 → 132
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:62 → 107
    F-box-like; F-box-like

  2. NM_013787.3 → NP_038815.1  S-phase kinase-associated protein 2 isoform a

    See identical proteins and their annotated locations for NP_038815.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC139209, AK166034, BY740905
    Consensus CDS
    CCDS37037.1
    UniProtKB/Swiss-Prot
    Q8BSG7, Q8C8Y9, Q8CB22, Q99J53, Q9Z0Z3
    UniProtKB/TrEMBL
    Q569Z9
    Related
    ENSMUSP00000094225.4, ENSMUST00000096482.10
    Conserved Domains (3) summary
    cd09293
    Location:193 → 345
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:137 → 167
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:97 → 142
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    9112070..9155512 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245359.3 → XP_011243661.1  S-phase kinase-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011243661.1

    Conserved Domains (3) summary
    cd09293
    Location:203 → 355
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:147 → 177
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:107 → 151
    F-box-like

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145468.1: Suppressed sequence

    Description
    NM_145468.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0Z3.1 GenPept UniProtKB/Swiss-Prot:Q9Z0Z3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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