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Mrpl2 mitochondrial ribosomal protein L2 [ Mus musculus (house mouse) ]

Gene ID: 27398, updated on 5-Mar-2024

Summary

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Official Symbol
Mrpl2provided by MGI
Official Full Name
mitochondrial ribosomal protein L2provided by MGI
Primary source
MGI:MGI:1351622
See related
Ensembl:ENSMUSG00000002767 AllianceGenome:MGI:1351622
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L2mt; CGI-22; MRP-L2; Rpml14; MRP-L14
Summary
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL2 (mitochondrial ribosomal protein L2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 57.3), ovary adult (RPKM 37.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 22.9 cM; 17 C
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46957094..46961058)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46646172..46650132)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7535 Neighboring gene microRNA 6976 Neighboring gene serum response factor Neighboring gene PTK7 protein tyrosine kinase 7 Neighboring gene VISTA enhancer mm1620 Neighboring gene STARR-seq mESC enhancer starr_42674 Neighboring gene STARR-seq mESC enhancer starr_42675 Neighboring gene STARR-positive B cell enhancer ABC_E10957 Neighboring gene kinesin light chain 4 Neighboring gene STARR-positive B cell enhancer ABC_E7536 Neighboring gene cullin 7 Neighboring gene STARR-seq mESC enhancer starr_42676 Neighboring gene ribosomal RNA processing 36

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences. O'Brien TW, et al. J Biol Chem, 1999 Dec 17. PMID 10593885
  2. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
  3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  4. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within translation ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit ISA
Inferred from Sequence Alignment
more info
 PubMed 
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein uL2m
Names
39S ribosomal protein L2, mitochondrial
ribosomal protein, mitochondrial, L14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316742.1 → NP_001303671.1  large ribosomal subunit protein uL2m isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5'-terminal exon, and differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC165445, AI837821, AK009521, BY343877
    UniProtKB/TrEMBL
    B1B1D8
    Conserved Domains (2) summary
    pfam00181
    Location:54 → 134
    Ribosomal_L2; Ribosomal Proteins L2, RNA binding domain
    pfam03947
    Location:150 → 241
    Ribosomal_L2_C; Ribosomal Proteins L2, C-terminal domain

  2. NM_001379057.1 → NP_001365986.1  large ribosomal subunit protein uL2m isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC165445, CT030702
    UniProtKB/TrEMBL
    B1B1D8
    Conserved Domains (1) summary
    cl40667
    Location:75 → 280
    RplB; Ribosomal protein L2 [Translation, ribosomal structure and biogenesis]

  3. NM_025302.4 → NP_079578.1  large ribosomal subunit protein uL2m isoform 1 precursor

    See identical proteins and their annotated locations for NP_079578.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI837821, AK009521, BY343877
    Consensus CDS
    CCDS37638.1
    UniProtKB/Swiss-Prot
    Q9D773
    UniProtKB/TrEMBL
    B1B1D8
    Related
    ENSMUSP00000002844.8, ENSMUST00000002844.14
    Conserved Domains (2) summary
    pfam00181
    Location:84 → 164
    Ribosomal_L2; Ribosomal Proteins L2, RNA binding domain
    pfam03947
    Location:180 → 271
    Ribosomal_L2_C; Ribosomal Proteins L2, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46957094..46961058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317496.2 → XP_017172985.1  large ribosomal subunit protein uL2m isoform X1

    UniProtKB/TrEMBL
    B1B1D8
    Conserved Domains (1) summary
    PRK09374
    Location:42 → 250
    rplB; 50S ribosomal protein L2; Validated
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D773.1 GenPept UniProtKB/Swiss-Prot:Q9D773

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