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Pign phosphatidylinositol glycan anchor biosynthesis, class N [ Mus musculus (house mouse) ]

Gene ID: 27392, updated on 11-Apr-2024

Summary

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Official Symbol
Pignprovided by MGI
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Nprovided by MGI
Primary source
MGI:MGI:1351629
See related
Ensembl:ENSMUSG00000056536 AllianceGenome:MGI:1351629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PIG-N; Gm20308
Summary
Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in cytosol and plasma membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in central nervous system and retina. Used to study holoprosencephaly. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 1. Orthologous to human PIGN (phosphatidylinositol glycan anchor biosynthesis class N). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 3.0), testis adult (RPKM 2.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pign in Genome Data Viewer
Location:
1 E2.1; 1 49.63 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (105446147..105591466, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (105518421..105663741, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 28403 Neighboring gene predicted gene, 57564 Neighboring gene STARR-seq mESC enhancer starr_01842 Neighboring gene 60S ribosomal protein L37a-like Neighboring gene STARR-positive B cell enhancer mm9_chr1:107527155-107527456 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:107559805-107559992 Neighboring gene STARR-positive B cell enhancer ABC_E988 Neighboring gene RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing Neighboring gene predicted gene 10193

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pig-n, a mammalian homologue of yeast Mcd4p, is involved in transferring phosphoethanolamine to the first mannose of the glycosylphosphatidylinositol. Hong Y, et al. J Biol Chem, 1999 Dec 3. PMID 10574991
  2. GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol. Shishioh N, et al. J Biol Chem, 2005 Mar 11. PMID 15632136
  3. Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly. McKean DM, et al. Biol Open, 2012 Sep 15. PMID 23213481, Free PMC Article
  4. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mannose-ethanolamine phosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphotransferase activity, for other substituted phosphate groups TAS
Traceable Author Statement
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GPI ethanolamine phosphate transferase 1
Names
phosphatidylinositol glycan, class N
phosphatidylinositol-glycan biosynthesis class N protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013784.3 → NP_038812.2  GPI ethanolamine phosphate transferase 1

    See identical proteins and their annotated locations for NP_038812.2

    Status: VALIDATED

    Source sequence(s)
    AC132082, AC166354
    Consensus CDS
    CCDS15205.1
    UniProtKB/Swiss-Prot
    Q3V0S6, Q8VCC3, Q9R1S1, Q9R1S2, Q9R1S3
    UniProtKB/TrEMBL
    G3X9F1
    Related
    ENSMUSP00000139638.2, ENSMUST00000186485.7
    Conserved Domains (2) summary
    cd16020
    Location:40 → 345
    GPI_EPT_1; GPI ethanolamine phosphate transferase 1; PIG-N
    pfam04987
    Location:431 → 884
    PigN; Phosphatidylinositolglycan class N (PIG-N)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    105446147..105591466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321076.2 → XP_017176565.1  GPI ethanolamine phosphate transferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3V0S6, Q8VCC3, Q9R1S1, Q9R1S2, Q9R1S3
    UniProtKB/TrEMBL
    G3X9F1
    Conserved Domains (2) summary
    cd16020
    Location:40 → 345
    GPI_EPT_1; GPI ethanolamine phosphate transferase 1; PIG-N
    pfam04987
    Location:431 → 884
    PigN; Phosphatidylinositolglycan class N (PIG-N)

  2. XM_006529676.5 → XP_006529739.1  GPI ethanolamine phosphate transferase 1 isoform X2

    UniProtKB/TrEMBL
    A0A087WQ32, A0A087WS03
    Related
    ENSMUSP00000140020.2, ENSMUST00000187537.7
    Conserved Domains (2) summary
    cd16020
    Location:40 → 345
    GPI_EPT_1; GPI ethanolamine phosphate transferase 1; PIG-N
    pfam04987
    Location:431 → 795
    PigN; Phosphatidylinositolglycan class N (PIG-N)

RNA

  1. XR_003955701.2 RNA Sequence

  2. XR_004942589.1 RNA Sequence

  3. XR_003955700.2 RNA Sequence

  4. XR_387175.4 RNA Sequence

  5. XR_387174.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1S3.2 GenPept UniProtKB/Swiss-Prot:Q9R1S3

Gene LinkOut

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