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Npas3 neuronal PAS domain protein 3 [ Mus musculus (house mouse) ]

Gene ID: 27386, updated on 12-Mar-2024

Summary

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Official Symbol
Npas3provided by MGI
Official Full Name
neuronal PAS domain protein 3provided by MGI
Primary source
MGI:MGI:1351610
See related
Ensembl:ENSMUSG00000021010 AllianceGenome:MGI:1351610
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
bHLHe12; 4930423H22Rik
Summary
Enables protein heterodimerization activity. Involved in positive regulation of transcription, DNA-templated. Acts upstream of or within locomotory behavior; maternal behavior; and startle response. Located in nucleus. Is expressed in several structures, including central nervous system; heart and pericardium; salivary gland; sensory organ; and urinary system. Orthologous to human NPAS3 (neuronal PAS domain protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 5.4), CNS E14 (RPKM 4.1) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 C1; 12 22.31 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (53294874..54118956)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (53248026..54072173)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene A kinase anchor protein 6 Neighboring gene STARR-seq mESC enhancer starr_32141 Neighboring gene predicted gene, 53720 Neighboring gene predicted gene, 18898 Neighboring gene RIKEN cDNA 1700030L22 gene Neighboring gene STARR-seq mESC enhancer starr_32144 Neighboring gene STARR-seq mESC enhancer starr_32145 Neighboring gene predicted gene, 51419 Neighboring gene STARR-seq mESC enhancer starr_32146 Neighboring gene STARR-seq mESC enhancer starr_32148 Neighboring gene STARR-seq mESC enhancer starr_32149 Neighboring gene STARR-seq mESC enhancer starr_32150 Neighboring gene STARR-seq mESC enhancer starr_32151 Neighboring gene VISTA enhancer mm1188 Neighboring gene STARR-seq mESC enhancer starr_32152 Neighboring gene STARR-seq mESC enhancer starr_32153 Neighboring gene STARR-seq mESC enhancer starr_32154 Neighboring gene STARR-seq mESC enhancer starr_32155 Neighboring gene STARR-seq mESC enhancer starr_32156 Neighboring gene STARR-seq mESC enhancer starr_32157 Neighboring gene predicted gene, 35818 Neighboring gene predicted gene, 40424

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Npas3 regulates stemness maintenance of radial glial cells and neuronal migration in the developing mouse cerebral cortex. Liu JW, et al. Front Cell Neurosci, 2022. PMID 36313621, Free PMC Article
  2. Discovery of a proneurogenic, neuroprotective chemical. Pieper AA, et al. Cell, 2010 Jul 9. PMID 20603013, Free PMC Article
  3. Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice. Brunskill EW, et al. Eur J Neurosci, 2005 Sep. PMID 16190882
  4. Novel alternative splice variants of chicken NPAS3 are expressed in the developing central nervous system. Shin J, et al. Gene, 2013 Nov 10. PMID 23962688
  5. Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3. Sha L, et al. Mol Psychiatry, 2012 Mar. PMID 21709683

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors.
    Title: Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors.
  2. Study provides a clear, unbiased view of the full spectrum of genes regulated by NPAS1 and NPAS3 and shows that these transcription factors are master regulators of neuropsychiatric function. These findings expose the molecular pathophysiology of NPAS1/3 mutations and provide a striking example of the shared, combinatorial nature of molecular pathways that underlie diagnostically distinct neuropsychiatric conditions.
    Title: Neuronal PAS Domain Proteins 1 and 3 Are Master Regulators of Neuropsychiatric Risk Genes.
  3. Most NPAS3 immunofluorescence originated in the subgranular zone of the dentate gyrus with immunopositive processes radiating into the granule cell layer proper. Npas3 acts during neuronal maturation/differentiation.
    Title: Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3.
  4. NPAS3 is a trachealess homolog critical for lung development and homeostasis.
    Title: NPAS3 is a trachealess homolog critical for lung development and homeostasis.
  5. Npas3-/- mice are deficient in expression of hippocampal FGF receptor subtype 1 mRNA.
    Title: The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice.
  6. our observations indicate an important role for Npas3 in controlling normal brain development and neurosignaling pathways
    Title: Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice.
  7. a regulatory program controlled in inhibitory interneurons by the NPAS1 and NPAS3 transcription factors may be either substantively or tangentially relevant to psychosis
    Title: Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within maternal behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within startle response IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neuronal PAS domain-containing protein 3
Names
basic-helix-loop-helix-PAS protein MOP6
member of PAS protein 6
neuronal PAS3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370960.1 → NP_001357889.1  neuronal PAS domain-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC139934, BC120885, CT030137
    UniProtKB/TrEMBL
    A0A1Y7VJG5, Q0IJ77
    Related
    ENSMUSP00000152411.3, ENSMUST00000223358.3
    Conserved Domains (4) summary
    smart00091
    Location:158 → 216
    PAS; PAS domain
    pfam08447
    Location:349 → 436
    PAS_3; PAS fold
    NF012181
    Location:475 → 598
    MSCRAMM_SdrD; MSCRAMM family adhesin SdrD
    cd19732
    Location:53 → 130
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

  2. NM_001370961.1 → NP_001357890.1  neuronal PAS domain-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC120181, AC125451, AC139934, AC159634, CR974571, CT030137
    UniProtKB/TrEMBL
    F8VQB2
    Conserved Domains (4) summary
    smart00091
    Location:188 → 246
    PAS; PAS domain
    pfam08447
    Location:379 → 466
    PAS_3; PAS fold
    NF000535
    Location:466 → 631
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
    cd19732
    Location:84 → 160
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

  3. NM_001370962.1 → NP_001357891.1  neuronal PAS domain-containing protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC120181, AC125451, AC139934, AC159634, CR974571, CT030137
    UniProtKB/TrEMBL
    F8VQB2
    Conserved Domains (4) summary
    smart00091
    Location:186 → 244
    PAS; PAS domain
    pfam08447
    Location:377 → 464
    PAS_3; PAS fold
    NF012181
    Location:503 → 626
    MSCRAMM_SdrD; MSCRAMM family adhesin SdrD
    cd19732
    Location:84 → 160
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

  4. NM_001370963.1 → NP_001357892.1  neuronal PAS domain-containing protein 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC120181, AC125451, AC139934, CR974571, CT030137
    UniProtKB/TrEMBL
    Q0IJ77
    Conserved Domains (4) summary
    smart00091
    Location:156 → 214
    PAS; PAS domain
    pfam08447
    Location:347 → 434
    PAS_3; PAS fold
    NF000535
    Location:434 → 599
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
    cd19732
    Location:53 → 130
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

  5. NM_001370964.1 → NP_001357893.1  neuronal PAS domain-containing protein 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC120181, AC125451, AC139934, AC159634, CR974571, CT030137
    UniProtKB/TrEMBL
    F8VQB2
    Conserved Domains (4) summary
    smart00091
    Location:203 → 261
    PAS; PAS domain
    pfam08447
    Location:394 → 481
    PAS_3; PAS fold
    NF000535
    Location:481 → 644
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
    cd19732
    Location:84 → 160
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

  6. NM_013780.3 → NP_038808.3  neuronal PAS domain-containing protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC139934, AF173871, CT030137
    Consensus CDS
    CCDS25907.1
    UniProtKB/TrEMBL
    F8VQB2
    Related
    ENSMUSP00000098975.3, ENSMUST00000101432.3
    Conserved Domains (4) summary
    smart00091
    Location:186 → 244
    PAS; PAS domain
    pfam08447
    Location:377 → 464
    PAS_3; PAS fold
    NF000535
    Location:464 → 629
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
    cd19732
    Location:84 → 160
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    53294874..54118956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515941.4 → XP_006516004.1  neuronal PAS domain-containing protein 3 isoform X21

    UniProtKB/TrEMBL
    F8VQB2
    Conserved Domains (3) summary
    smart00091
    Location:205 → 263
    PAS; PAS domain
    pfam08447
    Location:396 → 483
    PAS_3; PAS fold
    cd19732
    Location:84 → 160
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

  2. XM_030246748.2 → XP_030102608.1  neuronal PAS domain-containing protein 3 isoform X22

    UniProtKB/TrEMBL
    F8VQB2
    Conserved Domains (3) summary
    smart00091
    Location:203 → 261
    PAS; PAS domain
    pfam08447
    Location:394 → 481
    PAS_3; PAS fold
    cd19732
    Location:84 → 160
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

  3. XM_006515942.4 → XP_006516005.1  neuronal PAS domain-containing protein 3 isoform X27

    UniProtKB/TrEMBL
    Q0IJ77
    Related
    ENSMUSP00000152452.2, ENSMUST00000223057.2
    Conserved Domains (3) summary
    smart00091
    Location:175 → 233
    PAS; PAS domain
    pfam08447
    Location:366 → 453
    PAS_3; PAS fold
    cd19732
    Location:53 → 130
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

  4. XM_036157451.1 → XP_036013344.1  neuronal PAS domain-containing protein 3 isoform X28

    UniProtKB/TrEMBL
    Q0IJ77
    Conserved Domains (4) summary
    smart00091
    Location:173 → 231
    PAS; PAS domain
    pfam08447
    Location:364 → 451
    PAS_3; PAS fold
    cd19732
    Location:53 → 130
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033609
    Location:457 → 617
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

  5. XM_036157450.1 → XP_036013343.1  neuronal PAS domain-containing protein 3 isoform X23

    UniProtKB/TrEMBL
    F8VQB2
    Conserved Domains (4) summary
    smart00091
    Location:203 → 261
    PAS; PAS domain
    pfam08447
    Location:394 → 481
    PAS_3; PAS fold
    cd19732
    Location:84 → 160
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033845
    Location:521 → 643
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  6. XM_030246749.2 → XP_030102609.1  neuronal PAS domain-containing protein 3 isoform X24

    UniProtKB/TrEMBL
    F8VQB2
    Conserved Domains (3) summary
    smart00091
    Location:188 → 246
    PAS; PAS domain
    pfam08447
    Location:379 → 466
    PAS_3; PAS fold
    cd19732
    Location:84 → 160
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

  7. XM_030246750.2 → XP_030102610.1  neuronal PAS domain-containing protein 3 isoform X25

    UniProtKB/TrEMBL
    F8VQB2
    Conserved Domains (3) summary
    smart00091
    Location:186 → 244
    PAS; PAS domain
    pfam08447
    Location:377 → 464
    PAS_3; PAS fold
    cd19732
    Location:84 → 160
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

  8. XM_030246751.2 → XP_030102611.1  neuronal PAS domain-containing protein 3 isoform X26

    UniProtKB/TrEMBL
    F8VQB2
    Conserved Domains (4) summary
    smart00091
    Location:188 → 246
    PAS; PAS domain
    pfam08447
    Location:379 → 466
    PAS_3; PAS fold
    NF012181
    Location:505 → 628
    MSCRAMM_SdrD; MSCRAMM family adhesin SdrD
    cd19732
    Location:84 → 160
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

  9. XM_036157452.1 → XP_036013345.1  neuronal PAS domain-containing protein 3 isoform X29

    UniProtKB/TrEMBL
    Q0IJ77
    Conserved Domains (4) summary
    smart00091
    Location:158 → 216
    PAS; PAS domain
    pfam08447
    Location:349 → 436
    PAS_3; PAS fold
    cd19732
    Location:53 → 130
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033609
    Location:442 → 602
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

  10. XM_036157455.1 → XP_036013348.1  neuronal PAS domain-containing protein 3 isoform X32

    UniProtKB/TrEMBL
    Q0IJ77
    Conserved Domains (4) summary
    smart00091
    Location:158 → 216
    PAS; PAS domain
    pfam08447
    Location:349 → 436
    PAS_3; PAS fold
    cd19732
    Location:53 → 130
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033845
    Location:476 → 599
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  11. XM_036157454.1 → XP_036013347.1  neuronal PAS domain-containing protein 3 isoform X31

    UniProtKB/TrEMBL
    Q0IJ77
    Conserved Domains (4) summary
    smart00091
    Location:156 → 214
    PAS; PAS domain
    pfam08447
    Location:347 → 434
    PAS_3; PAS fold
    cd19732
    Location:53 → 130
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033609
    Location:440 → 600
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

  12. XM_036157453.1 → XP_036013346.1  neuronal PAS domain-containing protein 3 isoform X30

    UniProtKB/TrEMBL
    Q0IJ77
    Conserved Domains (4) summary
    smart00091
    Location:158 → 216
    PAS; PAS domain
    pfam08447
    Location:349 → 436
    PAS_3; PAS fold
    cd19732
    Location:53 → 130
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033845
    Location:476 → 601
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  13. XM_036157456.1 → XP_036013349.1  neuronal PAS domain-containing protein 3 isoform X33

    UniProtKB/TrEMBL
    Q0IJ77
    Conserved Domains (4) summary
    smart00091
    Location:156 → 214
    PAS; PAS domain
    pfam08447
    Location:347 → 434
    PAS_3; PAS fold
    cd19732
    Location:53 → 130
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033845
    Location:474 → 596
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  14. XM_030246754.2 → XP_030102614.1  neuronal PAS domain-containing protein 3 isoform X35

    UniProtKB/TrEMBL
    Q0IJ77
    Conserved Domains (4) summary
    smart00091
    Location:65 → 123
    PAS; PAS domain
    pfam08447
    Location:256 → 343
    PAS_3; PAS fold
    NF000535
    Location:377 → 500
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
    cl00081
    Location:1 → 22
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  15. XM_036157459.1 → XP_036013352.1  neuronal PAS domain-containing protein 3 isoform X36

    UniProtKB/TrEMBL
    Q0IJ77
    Conserved Domains (4) summary
    smart00091
    Location:50 → 108
    PAS; PAS domain
    pfam08447
    Location:241 → 328
    PAS_3; PAS fold
    NF033609
    Location:334 → 494
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
    cl00081
    Location:1 → 22
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  16. XM_036157460.1 → XP_036013353.1  neuronal PAS domain-containing protein 3 isoform X38

    UniProtKB/TrEMBL
    Q0IJ77
    Conserved Domains (4) summary
    smart00091
    Location:48 → 106
    PAS; PAS domain
    pfam08447
    Location:239 → 326
    PAS_3; PAS fold
    NF033609
    Location:332 → 492
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
    cl00081
    Location:1 → 22
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  17. XM_036157458.1 → XP_036013351.1  neuronal PAS domain-containing protein 3 isoform X36

    UniProtKB/TrEMBL
    Q0IJ77
    Conserved Domains (4) summary
    smart00091
    Location:50 → 108
    PAS; PAS domain
    pfam08447
    Location:241 → 328
    PAS_3; PAS fold
    NF033609
    Location:334 → 494
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
    cl00081
    Location:1 → 22
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  18. XM_036157457.1 → XP_036013350.1  neuronal PAS domain-containing protein 3 isoform X34

    UniProtKB/TrEMBL
    A0A1Y7VM06
    Conserved Domains (4) summary
    smart00091
    Location:67 → 125
    PAS; PAS domain
    pfam08447
    Location:258 → 345
    PAS_3; PAS fold
    NF033609
    Location:351 → 511
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
    cl00081
    Location:1 → 22
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  19. XM_036157462.1 → XP_036013355.1  neuronal PAS domain-containing protein 3 isoform X40

    Conserved Domains (2) summary
    smart00091
    Location:461 → 499
    PAS; PAS domain
    cd19732
    Location:357 → 433
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

  20. XM_036157463.1 → XP_036013356.1  neuronal PAS domain-containing protein 3 isoform X41

    Conserved Domains (2) summary
    smart00091
    Location:459 → 497
    PAS; PAS domain
    cd19732
    Location:357 → 433
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

  21. XM_036157464.1 → XP_036013357.1  neuronal PAS domain-containing protein 3 isoform X42

    Conserved Domains (1) summary
    cd19732
    Location:357 → 433
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

  22. XM_036157437.1 → XP_036013330.1  neuronal PAS domain-containing protein 3 isoform X1

    Conserved Domains (4) summary
    smart00091
    Location:478 → 536
    PAS; PAS domain
    pfam08447
    Location:669 → 756
    PAS_3; PAS fold
    cd19732
    Location:357 → 433
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033609
    Location:762 → 922
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

  23. XM_036157440.1 → XP_036013333.1  neuronal PAS domain-containing protein 3 isoform X5

    Conserved Domains (4) summary
    smart00091
    Location:478 → 536
    PAS; PAS domain
    pfam08447
    Location:669 → 756
    PAS_3; PAS fold
    cd19732
    Location:357 → 433
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033845
    Location:796 → 919
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  24. XM_036157438.1 → XP_036013331.1  neuronal PAS domain-containing protein 3 isoform X3

    Conserved Domains (4) summary
    smart00091
    Location:476 → 534
    PAS; PAS domain
    pfam08447
    Location:667 → 754
    PAS_3; PAS fold
    cd19732
    Location:357 → 433
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033609
    Location:760 → 920
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

  25. XM_006515938.4 → XP_006516001.2  neuronal PAS domain-containing protein 3 isoform X2

    Conserved Domains (4) summary
    smart00091
    Location:478 → 536
    PAS; PAS domain
    pfam08447
    Location:669 → 756
    PAS_3; PAS fold
    cd19732
    Location:357 → 433
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033845
    Location:796 → 921
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  26. XM_030246744.2 → XP_030102604.2  neuronal PAS domain-containing protein 3 isoform X6

    Conserved Domains (4) summary
    smart00091
    Location:478 → 536
    PAS; PAS domain
    pfam08447
    Location:669 → 756
    PAS_3; PAS fold
    cd19732
    Location:357 → 433
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033845
    Location:796 → 918
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  27. XM_036157439.1 → XP_036013332.1  neuronal PAS domain-containing protein 3 isoform X4

    Conserved Domains (4) summary
    smart00091
    Location:476 → 534
    PAS; PAS domain
    pfam08447
    Location:667 → 754
    PAS_3; PAS fold
    cd19732
    Location:357 → 433
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033845
    Location:794 → 919
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  28. XM_036157441.1 → XP_036013334.1  neuronal PAS domain-containing protein 3 isoform X7

    Conserved Domains (4) summary
    smart00091
    Location:476 → 534
    PAS; PAS domain
    pfam08447
    Location:667 → 754
    PAS_3; PAS fold
    cd19732
    Location:357 → 433
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033845
    Location:794 → 916
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  29. XM_036157442.1 → XP_036013335.1  neuronal PAS domain-containing protein 3 isoform X8

    Conserved Domains (4) summary
    smart00091
    Location:461 → 519
    PAS; PAS domain
    pfam08447
    Location:652 → 739
    PAS_3; PAS fold
    cd19732
    Location:357 → 433
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033609
    Location:745 → 905
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

  30. XM_006515939.4 → XP_006516002.2  neuronal PAS domain-containing protein 3 isoform X9

    Conserved Domains (4) summary
    smart00091
    Location:461 → 519
    PAS; PAS domain
    pfam08447
    Location:652 → 739
    PAS_3; PAS fold
    cd19732
    Location:357 → 433
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033845
    Location:779 → 904
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  31. XM_036157443.1 → XP_036013336.1  neuronal PAS domain-containing protein 3 isoform X12

    Conserved Domains (4) summary
    smart00091
    Location:461 → 519
    PAS; PAS domain
    pfam08447
    Location:652 → 739
    PAS_3; PAS fold
    cd19732
    Location:357 → 433
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033845
    Location:779 → 902
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  32. XM_030246746.2 → XP_030102606.2  neuronal PAS domain-containing protein 3 isoform X13

    Conserved Domains (4) summary
    smart00091
    Location:461 → 519
    PAS; PAS domain
    pfam08447
    Location:652 → 739
    PAS_3; PAS fold
    cd19732
    Location:357 → 433
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033845
    Location:779 → 901
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  33. XM_030246745.2 → XP_030102605.2  neuronal PAS domain-containing protein 3 isoform X10

    Conserved Domains (4) summary
    smart00091
    Location:459 → 517
    PAS; PAS domain
    pfam08447
    Location:650 → 737
    PAS_3; PAS fold
    cd19732
    Location:357 → 433
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033609
    Location:743 → 903
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

  34. XM_006515940.4 → XP_006516003.2  neuronal PAS domain-containing protein 3 isoform X11

    Conserved Domains (4) summary
    smart00091
    Location:459 → 517
    PAS; PAS domain
    pfam08447
    Location:650 → 737
    PAS_3; PAS fold
    cd19732
    Location:357 → 433
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033845
    Location:777 → 902
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  35. XM_030246747.2 → XP_030102607.2  neuronal PAS domain-containing protein 3 isoform X14

    Conserved Domains (4) summary
    smart00091
    Location:459 → 517
    PAS; PAS domain
    pfam08447
    Location:650 → 737
    PAS_3; PAS fold
    cd19732
    Location:357 → 433
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033845
    Location:777 → 899
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  36. XM_036157444.1 → XP_036013337.1  neuronal PAS domain-containing protein 3 isoform X15

    Conserved Domains (4) summary
    smart00091
    Location:448 → 506
    PAS; PAS domain
    pfam08447
    Location:639 → 726
    PAS_3; PAS fold
    cd19732
    Location:326 → 403
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033609
    Location:732 → 892
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

  37. XM_036157445.1 → XP_036013338.1  neuronal PAS domain-containing protein 3 isoform X16

    Conserved Domains (4) summary
    smart00091
    Location:446 → 504
    PAS; PAS domain
    pfam08447
    Location:637 → 724
    PAS_3; PAS fold
    cd19732
    Location:326 → 403
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033609
    Location:730 → 890
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

  38. XM_036157446.1 → XP_036013339.1  neuronal PAS domain-containing protein 3 isoform X17

    Conserved Domains (4) summary
    smart00091
    Location:446 → 504
    PAS; PAS domain
    pfam08447
    Location:637 → 724
    PAS_3; PAS fold
    cd19732
    Location:326 → 403
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033845
    Location:764 → 886
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  39. XM_036157447.1 → XP_036013340.1  neuronal PAS domain-containing protein 3 isoform X18

    Conserved Domains (4) summary
    smart00091
    Location:431 → 489
    PAS; PAS domain
    pfam08447
    Location:622 → 709
    PAS_3; PAS fold
    cd19732
    Location:326 → 403
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033609
    Location:715 → 875
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

  40. XM_036157448.1 → XP_036013341.1  neuronal PAS domain-containing protein 3 isoform X19

    Conserved Domains (4) summary
    smart00091
    Location:431 → 489
    PAS; PAS domain
    pfam08447
    Location:622 → 709
    PAS_3; PAS fold
    cd19732
    Location:326 → 403
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033845
    Location:749 → 874
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  41. XM_036157449.1 → XP_036013342.1  neuronal PAS domain-containing protein 3 isoform X20

    Conserved Domains (4) summary
    smart00091
    Location:429 → 487
    PAS; PAS domain
    pfam08447
    Location:620 → 707
    PAS_3; PAS fold
    cd19732
    Location:326 → 403
    bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
    NF033609
    Location:713 → 873
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

  42. XM_030246752.2 → XP_030102612.1  neuronal PAS domain-containing protein 3 isoform X34

    UniProtKB/TrEMBL
    A0A1Y7VM06
    Conserved Domains (4) summary
    smart00091
    Location:67 → 125
    PAS; PAS domain
    pfam08447
    Location:258 → 345
    PAS_3; PAS fold
    NF033609
    Location:351 → 511
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
    cl00081
    Location:1 → 22
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  43. XM_030246756.2 → XP_030102616.1  neuronal PAS domain-containing protein 3 isoform X37

    UniProtKB/TrEMBL
    A0A1Y7VM06
    Conserved Domains (4) summary
    smart00091
    Location:50 → 108
    PAS; PAS domain
    pfam08447
    Location:241 → 328
    PAS_3; PAS fold
    NF000535
    Location:328 → 493
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
    cl00081
    Location:1 → 22
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  44. XM_036157461.1 → XP_036013354.1  neuronal PAS domain-containing protein 3 isoform X39

    UniProtKB/TrEMBL
    A0A1Y7VM06
    Conserved Domains (4) summary
    smart00091
    Location:48 → 106
    PAS; PAS domain
    pfam08447
    Location:239 → 326
    PAS_3; PAS fold
    NF033845
    Location:366 → 491
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    cl00081
    Location:1 → 22
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZQ0.1 GenPept UniProtKB/Swiss-Prot:Q9QZQ0

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