Tjp3 tight junction protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tjp3provided by MGI
Official Full Name: tight junction protein 3provided by MGI
Primary source: MGI:MGI:1351650
See related: Ensembl:ENSMUSG00000034917 AllianceGenome:MGI:1351650
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within regulation of G1/S transition of mitotic cell cycle. Located in several cellular components, including apical plasma membrane; bicellular tight junction; and cytosol. Is expressed in alimentary system epithelium and genitourinary system. Orthologous to human TJP3 (tight junction protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 107.2), duodenum adult (RPKM 76.5) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (81109022..81127415, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (81273188..81291581, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZO-3 shows an epithelial-specific Tight junctions localization
Title: Roles of ZO-1 and ZO-2 in establishment of the belt-like adherens and tight junctions with paracellular permselective barrier function.
Early embryonic lethality of mice lacking Tjp2, but not Tjp3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development.
Title: Early embryonic lethality of mice lacking ZO-2, but Not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development.
ZO-3 (-/-) mice were viable and fertile and their tight junctions did not appear to be affected.
Title: Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131893 (e-PCR)
- UniSTS:215176

RH128401 (e-PCR)
- UniSTS:211709

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of endothelial intestinal barrier	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of blood-brain barrier permeability	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tight junction protein ZO-3

Names: zona occludens protein 3; zonula occludens protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282095.1 → NP_001269024.1 tight junction protein ZO-3 isoform 2

See identical proteins and their annotated locations for NP_001269024.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.

Source sequence(s)

AK029083, AK167587, AV236903

Consensus CDS

CCDS24051.1

UniProtKB/TrEMBL

Q3UZ47, Q921G9

Related

ENSMUSP00000151601.2, ENSMUST00000219479.2

Conserved Domains (3) summary

smart00072
Location:580 → 756

GuKc; Guanylate kinase homologues

cd00992
Location:369 → 434

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl17036
Location:464 → 537

SH3; Src Homology 3 domain superfamily
NM_001282096.1 → NP_001269025.1 tight junction protein ZO-3 isoform 1

See identical proteins and their annotated locations for NP_001269025.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AC155937, AK029083, AV236903, BY102203

UniProtKB/TrEMBL

Q3UZ47

Conserved Domains (4) summary

smart00072
Location:589 → 765

GuKc; Guanylate kinase homologues

cd00992
Location:378 → 443

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:620 → 764

Guanylate_kin; Guanylate kinase

cl17036
Location:473 → 546

SH3; Src Homology 3 domain superfamily
NM_013769.3 → NP_038797.2 tight junction protein ZO-3 isoform 2

See identical proteins and their annotated locations for NP_038797.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.

Source sequence(s)

AK029083, AK134100, AV236903

Consensus CDS

CCDS24051.1

UniProtKB/TrEMBL

Q3UZ47, Q921G9

Related

ENSMUSP00000036438.7, ENSMUST00000045744.7

Conserved Domains (3) summary

smart00072
Location:580 → 756

GuKc; Guanylate kinase homologues

cd00992
Location:369 → 434

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl17036
Location:464 → 537

SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

81109022..81127415 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513708.4 → XP_006513771.1 tight junction protein ZO-3 isoform X1

See identical proteins and their annotated locations for XP_006513771.1

UniProtKB/TrEMBL

Q3UZ47, Q921G9

Conserved Domains (3) summary

smart00072
Location:580 → 756

GuKc; Guanylate kinase homologues

cd00992
Location:369 → 434

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl17036
Location:464 → 537

SH3; Src Homology 3 domain superfamily