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Sh2d2a SH2 domain containing 2A [ Mus musculus (house mouse) ]

Gene ID: 27371, updated on 11-Apr-2024

Summary

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Official Symbol
Sh2d2aprovided by MGI
Official Full Name
SH2 domain containing 2Aprovided by MGI
Primary source
MGI:MGI:1351596
See related
Ensembl:ENSMUSG00000028071 AllianceGenome:MGI:1351596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lad; Ribp; Tsad
Summary
Predicted to enable protein-macromolecule adaptor activity. Acts upstream of or within cell population proliferation. Predicted to be located in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in juvenile rheumatoid arthritis and multiple sclerosis. Orthologous to human SH2D2A (SH2 domain containing 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 35.7), spleen adult (RPKM 8.0) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Sh2d2a in Genome Data Viewer
Location:
3 F1; 3 38.78 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87754070..87763116)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87846755..87855722)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40086 Neighboring gene predicted gene, 32470 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:87650795-87651072 Neighboring gene papillary renal cell carcinoma (translocation-associated) Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:87689595-87689778 Neighboring gene STARR-seq mESC enhancer starr_08164 Neighboring gene STARR-seq mESC enhancer starr_08165 Neighboring gene heparin binding growth factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Polarity of CD4+ T cells towards the antigen presenting cell is regulated by the Lck adapter TSAd. Abrahamsen G, et al. Sci Rep, 2018 Sep 6. PMID 30190583, Free PMC Article
  2. Reduced MCMV Δm157 viral clearance in the absence of TSAd. Moussa P, et al. Sci Rep, 2015 Mar 18. PMID 25783199, Free PMC Article
  3. SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice. Berge T, et al. PLoS One, 2012. PMID 23144743, Free PMC Article
  4. The effector functions of mature T lymphocytes are impaired in transgenic mice expressing the SH2 domain of TSAd/Lad. Choi Y, et al. Mol Cells, 2009 Sep. PMID 19756394
  5. Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells. Marti F, et al. J Exp Med, 2006 Feb 20. PMID 16446380, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TSAd Plays a Major Role in Myo9b-Mediated Suppression of Malignant Pleural Effusion by Regulating TH1/TH17 Cell Response.
    Title: TSAd Plays a Major Role in Myo9b-Mediated Suppression of Malignant Pleural Effusion by Regulating T(H)1/T(H)17 Cell Response.
  2. The TSAd serves as a critical cell-intrinsic molecule in CD4(+)Foxp3(+) Tregs to regulate the translocation of Lck to mitochondria, cellular activation responses, and the development of immunoregulation following solid organ transplantation.
    Title: T Cell-Specific Adaptor Protein Regulates Mitochondrial Function and CD4(+) T Regulatory Cell Activity In Vivo following Transplantation.
  3. data suggest that TSAd modulates differentiation of experienced T cells possibly through polarization of CD4+ T cells towards the APC.
    Title: Polarity of CD4+ T cells towards the antigen presenting cell is regulated by the Lck adapter TSAd.
  4. These results revealed that vascular sprouting and permeability are both controlled through the VEGFR2-TSAd-c-Src signaling pathway in a subset of tissues, which may be useful in developing strategies to control tissue-specific pathological angiogenesis.
    Title: The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation.
  5. Sh2d2a protein deficient mice display reduced clearance of Dm157 MCMV infection in the spleen.
    Title: Reduced MCMV Δm157 viral clearance in the absence of TSAd.
  6. The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.
    Title: The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.
  7. Results suggest a modulatory role for T cell specific adapter protein SH2D2A in T cell mediated immune surveillance of cancer.
    Title: SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice.
  8. Data show that tyrosine phosphorylation of VEGF receptor 2 (VEGFR2) facilitates binding of VEGFR2 to the Rous sarcoma (Src) homology 2-domain of T cell-specific adaptor (TSAd), which in turn regulates VEGF-induced activation of the c-Src tyrosine kinase.
    Title: VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd.
  9. results show that TSAd, particularly the SH2 domain of TSAd, is essential for the effector functions of T cells.
    Title: The effector functions of mature T lymphocytes are impaired in transgenic mice expressing the SH2 domain of TSAd/Lad.
  10. TSAd, through its interaction with both Itk and Lck, primes Itk for Lck mediated phosphorylation and thereby regulates CXCL12 induced T cell migration and actin cytoskeleton rearrangements
    Title: T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SH2 domain-containing protein 2A
Names
Lck-associated adapter protein
Rlk/Itk-binding protein
SH2 domain protein 2A
T cell-specific adapter protein
p56Lck-associated adapter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025571.3 → NP_001020742.1  SH2 domain-containing protein 2A isoform 2

    See identical proteins and their annotated locations for NP_001020742.1

    Status: VALIDATED

    Source sequence(s)
    AC161454
    Consensus CDS
    CCDS17455.1
    UniProtKB/TrEMBL
    Q3TA00, Q5D0E4
    Related
    ENSMUSP00000029709.6, ENSMUST00000029709.7
    Conserved Domains (1) summary
    cd10416
    Location:108 → 209
    SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)

  2. NM_001411077.1 → NP_001398006.1  SH2 domain-containing protein 2A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC161454

  3. NM_021309.4 → NP_067284.1  SH2 domain-containing protein 2A isoform 1

    See identical proteins and their annotated locations for NP_067284.1

    Status: VALIDATED

    Source sequence(s)
    AC161454
    Consensus CDS
    CCDS38476.1
    UniProtKB/Swiss-Prot
    Q9JHP6, Q9QXK9
    UniProtKB/TrEMBL
    Q3TA00
    Related
    ENSMUSP00000103207.3, ENSMUST00000107581.9
    Conserved Domains (1) summary
    cd10416
    Location:108 → 209
    SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    87754070..87763116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163129.1 → XP_036019022.1  SH2 domain-containing protein 2A isoform X4

    Conserved Domains (1) summary
    cl15255
    Location:108 → 154
    SH2; Src homology 2 (SH2) domain

  2. XM_017319606.3 → XP_017175095.1  SH2 domain-containing protein 2A isoform X3

    UniProtKB/TrEMBL
    Q3TA00
    Conserved Domains (1) summary
    cl15255
    Location:108 → 225
    SH2; Src homology 2 (SH2) domain

  3. XM_006501554.4 → XP_006501617.1  SH2 domain-containing protein 2A isoform X1

    UniProtKB/TrEMBL
    Q3TA00
    Conserved Domains (1) summary
    cl15255
    Location:108 → 225
    SH2; Src homology 2 (SH2) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QXK9.1 GenPept UniProtKB/Swiss-Prot:Q9QXK9

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