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Txnl4a thioredoxin-like 4A [ Mus musculus (house mouse) ]

Gene ID: 27366, updated on 5-Mar-2024

Summary

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Official Symbol
Txnl4aprovided by MGI
Official Full Name
thioredoxin-like 4Aprovided by MGI
Primary source
MGI:MGI:1351613
See related
Ensembl:ENSMUSG00000057130 AllianceGenome:MGI:1351613
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dim1; Txnl4; U5-15kD; U5-15kDa; D18Wsu98e
Summary
Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Predicted to be part of U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex; and U5 snRNP. Is expressed in several structures, including brain ventricular layer; submandibular gland primordium; thymus primordium; tooth; and trigeminal ganglion. Human ortholog(s) of this gene implicated in Burn-McKeown syndrome. Orthologous to human TXNL4A (thioredoxin like 4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 29.5), CNS E11.5 (RPKM 21.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Txnl4a in Genome Data Viewer
Location:
18 E3; 18 53.34 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (80250041..80269066)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (80206826..80225851)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ribosome binding factor A, opposite strand Neighboring gene predicted gene, 46629 Neighboring gene STARR-positive B cell enhancer ABC_E5666 Neighboring gene ribosome binding factor A Neighboring gene N(alpha)-acetyltransferase 12, NatA catalytic subunit Neighboring gene heat shock factor binding protein 1-like 1 Neighboring gene solute carrier family 66 member 2 Neighboring gene STARR-seq mESC enhancer starr_45175

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15 kD protein. Reuter K, et al. J Mol Biol, 1999 Nov 26. PMID 10610776
  2. Minor spliceosome components are predominantly localized in the nucleus. Pessa HK, et al. Proc Natl Acad Sci U S A, 2008 Jun 24. PMID 18559850, Free PMC Article
  3. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
  4. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
  5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex ISO
Inferred from Sequence Orthology
more info
  
part_of U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U5 snRNP ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of U5 snRNP TAS
Traceable Author Statement
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
thioredoxin-like protein 4A
Names
DIM1 protein homolog
spliceosomal U5 snRNP-specific 15 kDa protein
thioredoxin-like 4
thioredoxin-like U5 snRNP protein U5-15kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038608.3 → NP_001033697.2  thioredoxin-like protein 4A isoform b

    See identical proteins and their annotated locations for NP_001033697.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding exons and 3' UTR compared to variant 1. The resulting isoform (b) is shorter and has a unique C-terminus compared to isoform a. Variants 2-4 all encode the same isoform (b).
    Source sequence(s)
    AC131065
    UniProtKB/TrEMBL
    Q78JM7
    Conserved Domains (1) summary
    cl00388
    Location:1 → 51
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  2. NM_001042408.2 → NP_001035867.1  thioredoxin-like protein 4A isoform b

    See identical proteins and their annotated locations for NP_001035867.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, 3' coding exons, and 3' UTR, compared to variant 1. The resulting isoform (b) is shorter and has a unique C-terminus compared to isoform a. Variants 2-4 all encode the same isoform (b).
    Source sequence(s)
    AC131065
    UniProtKB/TrEMBL
    Q78JM7
    Conserved Domains (1) summary
    cl00388
    Location:1 → 51
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  3. NM_001384173.1 → NP_001371102.1  thioredoxin-like protein 4A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1 and 6, encodes isoform a.
    Source sequence(s)
    AC131065
    UniProtKB/Swiss-Prot
    P83877, Q3TLI3
    Conserved Domains (1) summary
    PLN00410
    Location:1 → 142
    PLN00410; U5 snRNP protein, DIM1 family; Provisional

  4. NM_001384174.1 → NP_001371103.1  thioredoxin-like protein 4A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1 and 5, encodes isoform a.
    Source sequence(s)
    AC131065
    UniProtKB/Swiss-Prot
    P83877, Q3TLI3
    Conserved Domains (1) summary
    PLN00410
    Location:1 → 142
    PLN00410; U5 snRNP protein, DIM1 family; Provisional

  5. NM_001384175.1 → NP_001371104.1  thioredoxin-like protein 4A isoform c

    Status: VALIDATED

    Source sequence(s)
    AC131065
    Conserved Domains (1) summary
    cl00388
    Location:1 → 51
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  6. NM_001384176.1 → NP_001371105.1  thioredoxin-like protein 4A isoform d

    Status: VALIDATED

    Source sequence(s)
    AC131065
    Conserved Domains (1) summary
    cl00388
    Location:1 → 51
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  7. NM_001384177.1 → NP_001371106.1  thioredoxin-like protein 4A isoform e

    Status: VALIDATED

    Source sequence(s)
    AC131065
    Conserved Domains (1) summary
    cl00388
    Location:1 → 51
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  8. NM_025299.4 → NP_079575.1  thioredoxin-like protein 4A isoform a

    See identical proteins and their annotated locations for NP_079575.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AC131065
    Consensus CDS
    CCDS29365.1
    UniProtKB/Swiss-Prot
    P83877, Q3TLI3
    Related
    ENSMUSP00000115320.2, ENSMUST00000145963.9
    Conserved Domains (1) summary
    PLN00410
    Location:1 → 142
    PLN00410; U5 snRNP protein, DIM1 family; Provisional

  9. NM_178604.4 → NP_848719.2  thioredoxin-like protein 4A isoform b

    See identical proteins and their annotated locations for NP_848719.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' coding exons, and 3' UTR, compared to variant 1. The resulting isoform (b) is shorter and has a unique C-terminus compared to isoform a. Variants 2-4 all encode the same isoform (b).
    Source sequence(s)
    AC131065
    UniProtKB/TrEMBL
    Q78JM7
    Conserved Domains (1) summary
    cl00388
    Location:1 → 51
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RNA

  1. NR_168913.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131065

  2. NR_168914.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131065

  3. NR_168915.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131065

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    80250041..80269066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001042409.1: Suppressed sequence

    Description
    NM_001042409.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83877.1 GenPept UniProtKB/Swiss-Prot:P83877

Gene LinkOut

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